Heart News and Research

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Heart failure arises from mutations in distinct genes, study finds

Heart failure is a common and devastating disorder for which there is no cure. Many cardiomyopathies - conditions that make it difficult for the heart to pump blood such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) - can lead to heart failure, but treatments for patients with heart failure do not take these distinct conditions into account.

5 Aug 2022

Study provides new insight into the cellular and molecular biology of human heart failure

Studying heart samples from patients with cardiomyopathies, as well as from controls without heart disease, researchers have provided new insights into the cellular and molecular biology of human heart failure – a highly fatal condition that affects 23 million people worldwide.

5 Aug 2022

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

In a potential game changer for patients with type 2 diabetes, a team of researchers at the Diabetes, Obesity, and Metabolism Institute (DOMI) at the Icahn School of Medicine at Mount Sinai has identified a therapeutic target for the preservation and regeneration of beta cells (β cells) - cells in the pancreas that produce and distribute insulin.

4 Aug 2022

Individual genetic defects lead to heart failure in different ways, consortium reports

Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in Science.

4 Aug 2022

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

Low-cost, stretchable sponge electrodes for recording of high-quality electrophysiologic signals

To monitor heart rhythms and muscle function, doctors often attach electrodes to a patient's skin, detecting the electrical signals that lie beneath.

4 Aug 2022

Early-life acquisition of antibiotic resistance in neonates from developing countries

Every year, almost 7 million potentially serious bacterial infections are estimated to occur in newborns, resulting in more than 550,000 annual neonatal deaths.

4 Aug 2022

Exposure to air pollutants released during wildfires has ill effects among children

New research linking air pollution data from federal monitors in the Sacramento area of California, including during significant fires, is showing ill effects of pollution exposure among children, a new University of California, Davis, study suggests.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

New easy-to-use test could rapidly diagnose heart attacks and cancers

Imperial researchers have built a new easy-to-use test that could diagnose non-infectious diseases like heart attacks and cancers more quickly.

4 Aug 2022

Higher suPAR levels linked with increased risk of blood clot formation

Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms - blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.

4 Aug 2022

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress - an imbalance in the normal oxidation/reduction, or redox, homeostasis - caused pathological changes associated with heart failure in a mouse model.

3 Aug 2022

Study: Genes involved in coronary heart disease may be nearly the same for everyone

The genes involved in coronary heart disease, the most common form of heart disease, appear to be nearly the same for everyone, according to a VA study.

3 Aug 2022

Common viruses may play a role in some cases of Alzheimer's disease

Researchers from Oxford's Institute of Population Ageing, Tufts University and the University of Manchester have discovered that common viruses appear to play a role in some cases of Alzheimer's disease (AD).

3 Aug 2022

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

The Boston-based LeDucq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it.

3 Aug 2022

Women with a history of hypertensive disorders of pregnancy more likely to develop dementia

Hypertensive disorders of pregnancy (HDP) — conditions of high blood pressure including chronic/gestational hypertension and preeclampsia — have been strongly linked to heart disease in later life, but, before today, little research has connected these disorders with cognition.

3 Aug 2022

Women with a history of preeclampsia have increased markers of brain cell damage, inflammation

Preeclampsia is a serious complication of pregnancy characterized by high blood pressure and kidney damage.

3 Aug 2022

Substantial increases in cardiovascular trends contribute to a rising burden on the US health care system

By the year 2060, projected rates of cardiovascular risk factors and disease will increase significantly in the United States, according to a study published today in the Journal of the American College of Cardiology. Substantial increases in cardiovascular trends may contribute to a rising burden on the U.S. health care system and highlight the need for equitable access to prevention education and treatments now to prevent future disease.

3 Aug 2022

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Morphogens are molecules that travel from biological cell to cell to pattern tissues in the embryo. These molecules are important not only for the embryo during development, but also for the adult during tissue repair.

2 Aug 2022

Integrated behavioral intervention effective at reducing depression and anxiety in obese adults

Results from a pilot clinical trial show that among a racially and ethnically diverse cohort of adults who were obese and depressed, an integrated behavioral intervention was more effective than usual care at reducing depression and associated anxiety symptoms than it was at promoting weight loss.

2 Aug 2022

Heart News and Research

Heart failure arises from mutations in distinct genes, study finds

Study provides new insight into the cellular and molecular biology of human heart failure

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

Individual genetic defects lead to heart failure in different ways, consortium reports

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Low-cost, stretchable sponge electrodes for recording of high-quality electrophysiologic signals

Early-life acquisition of antibiotic resistance in neonates from developing countries

Exposure to air pollutants released during wildfires has ill effects among children

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

New easy-to-use test could rapidly diagnose heart attacks and cancers

Higher suPAR levels linked with increased risk of blood clot formation

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Study: Genes involved in coronary heart disease may be nearly the same for everyone

Common viruses may play a role in some cases of Alzheimer's disease

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

Women with a history of hypertensive disorders of pregnancy more likely to develop dementia

Women with a history of preeclampsia have increased markers of brain cell damage, inflammation

Substantial increases in cardiovascular trends contribute to a rising burden on the US health care system

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Integrated behavioral intervention effective at reducing depression and anxiety in obese adults

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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