Central Nervous System News and Research

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Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Insilico Medicine ("Insilico"), a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that the company's drug discovery team has nominated a preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy utilizing its end-to-end Pharma.AI platform.

27 Dec 2022

Neural electrical activity-based brain-computer interfaces for interacting with the human deep brain

Brain-Machine Interface (BMI, also known as Brain-Computer Interface) provides a new dimension for human to interact with machines and the environment.

27 Dec 2022

First cell-type specific multiomic study of the HIV brain

Researchers identify cell-type-specific differences in HIV integration sites in the brain.

19 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

Common type 2 diabetes drug requires the presence of GDF15 cytokine to present antidiabetic effects

Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the growth differentiation factor 15 (GDF15) —a protein whose expression increases in response to cellular stress— to present its antidiabetic effects.

16 Dec 2022

Study provides new insights into the pathology of LATE

Limbic predominate age-related TDP-43 encephalopathy or LATE is a recently recognized form of dementia that affects memory, thinking and social skills. It mimics Alzheimer's disease or AD (and sometimes co-exists with it), but LATE is a different condition, with its own risks and causes.

16 Dec 2022

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Late-breaking research reveals a major treatment advance for adults with newly diagnosed B lineage acute lymphoblastic leukemia (ALL).

14 Dec 2022

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Researchers from The University of Texas MD Anderson Cancer Center are presenting compelling findings from three clinical trials at the 2022 American Society of Hematology Annual Meeting.

13 Dec 2022

Report makes recommendations clarifying the ethics and oversight of chimeric research

A new report on the ethics of crossing species boundaries by inserting human cells into nonhuman animals – research surrounded by debate – makes recommendations clarifying the ethical issues and calling for improved oversight of this work.

13 Dec 2022

Study: Only 30% of people with neuroendocrine tumors consider living longer as top priority

New research from cancer research and treatment organization City of Hope in the December 2022 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds that only 30% of patients with advanced neuroendocrine tumors (NETs) say their top goal for treatment is living longer.

12 Dec 2022

Artificial sweetener linked to anxiety-like behavior in mice

Florida State University College of Medicine researchers have linked aspartame, an artificial sweetener found in nearly 5,000 diet foods and drinks, to anxiety-like behavior in mice.

8 Dec 2022

Researchers gain new insights into ADHD drug's mechanism of action

For decades, doctors have treated kids with attention-deficit/hyperactivity disorder (ADHD) with methylphenidate, a stimulant drug sold as Ritalin and Concerta, making it one of the most widely prescribed medications aimed at the central nervous system.

8 Dec 2022

T-DXd shows high efficacy in HER2-positive breast cancer patients previously treated with T-DM1

Compared with capecitabine-based regimens, trastuzumab deruxtecan (T-DXd) led to higher response rates and longer survival in the third-line setting for patients with HER2-positive metastatic breast cancer previously treated with trastuzumab emtansine (T-DM1), according to results from the phase III DESTINY-Breast02 trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Improved early detection and analysis of airborne pathogens with new liquid-coated air filters

Researchers from the University of Maine and University of Massachusetts Amherst have designed new liquid-coated air filters that allow for improved early detection and analysis of airborne bacteria and viruses, including the one that causes COVID-19.

7 Dec 2022

Does irritable bowel syndrome result from gravity?

New research discussed the hypothesis that irritable bowel syndrome (IBS) may result from gravity.

5 Dec 2022

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

The German Research Foundation (DFG) has approved the establishment and funding of the Collaborative Research Center/Transregio (CRC/TRR) 355 "Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments".

2 Dec 2022

The potential of grape consumption to modulate UV-induced skin erythema

A recent Antioxidants study evaluated the effect of grape consumption on reducing UV-induced skin erythema.

2 Dec 2022

Collaborative work unravels hidden molecular secrets of age-related diseases

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, and the University of Copenhagen announced today the release of the first batch of results from the collaborative work directed to perform multi-omics-based analyses in the context of age-related diseases using an AI-driven target and drug discovery pipeline.

2 Dec 2022

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

A five-year, nearly $3.5 million grant to study the mechanisms of brain receptors involved in neurological disorders such as learning disabilities has been awarded to Vasanthi Jayaraman, PhD, of UTHealth Houston by the National Institutes of Health.

1 Dec 2022

Researchers explore gut microbiome dysbiosis in acute COVID-19 infection and recovery

Researchers assessed the taxonomic characteristics of the intestinal (gut) microbiome in patients with active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

30 Nov 2022

Central Nervous System News and Research

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Neural electrical activity-based brain-computer interfaces for interacting with the human deep brain

First cell-type specific multiomic study of the HIV brain

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Common type 2 diabetes drug requires the presence of GDF15 cytokine to present antidiabetic effects

Study provides new insights into the pathology of LATE

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Report makes recommendations clarifying the ethics and oversight of chimeric research

Study: Only 30% of people with neuroendocrine tumors consider living longer as top priority

Artificial sweetener linked to anxiety-like behavior in mice

Researchers gain new insights into ADHD drug's mechanism of action

T-DXd shows high efficacy in HER2-positive breast cancer patients previously treated with T-DM1

Improved early detection and analysis of airborne pathogens with new liquid-coated air filters

Does irritable bowel syndrome result from gravity?

New Collaborative Research Center investigates how Treg cells influence immunological and tissue-specific diseases

The potential of grape consumption to modulate UV-induced skin erythema

Collaborative work unravels hidden molecular secrets of age-related diseases

UTHealth Houston professor wins $3.5 million to study the mechanisms of brain receptors involved in neurological disorders

Researchers explore gut microbiome dysbiosis in acute COVID-19 infection and recovery

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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