Lipoprotein News and Research

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A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins.

Gene variant linked with Mediterranean diet pattern prevents stroke

A gene variant strongly associated with development of type 2 diabetes appears to interact with a Mediterranean diet pattern to prevent stroke, report researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University and from the CIBER Fisiopatolog-a de la Obesidad y Nutriciόn in Spain.

14 Aug 2013

European authorisation of Aegerion Pharmaceuticals' Lojuxta brings hope for HoFH patients

Aegerion Pharmaceuticals, Inc., a biopharmaceutical company dedicated to the development and commercialisation of novel, life-altering therapies for patients with debilitating, often fatal, rare diseases, announced today that the European Commission has authorised Lojuxta (lomitapide) hard capsules as an adjunct to a low-fat diet and other lipid-lowering medicinal products with or without low density lipoprotein apheresis in adult patients with homozygous familial hypercholesterolaemia.

3 Aug 2013

Study leads to new approach for treatment of aortic valve stenosis

A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute, has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease.

19 Jul 2013

Researchers are one step closer to finding solution for atherosclerosis in diabetic patients

Researchers at Joslin Diabetes Center have discovered that when excessive PKC beta is found in the endothelium, the thin layer of cells that line blood vessels, atherosclerosis is exacerbated. Their findings were published on-line on June 11 by Circulation Research.

11 Jul 2013

Researchers find RNA molecule that interferes with lipoprotein production, reduces hyperlipidemia

Hyperlipidemia, a condition with high levels of fats circulating in the bloodstream, is a known risk factor for various cardiovascular and metabolic disorders. While the Western diet often contributes to high levels of lipids such as cholesterol and triglycerides, over-production of the body's own lipoproteins can lead to hyperlipidemia, independent of food intake.

25 Jun 2013

Gene switch off may increase risk of heart and blood vessel disease: Research

Risk of heart and blood vessel disease may increase when a particular gene is switched off, according to preliminary research presented at the American Heart Association's Emerging Science Series Webinar.

20 Jun 2013

LDL cholesterol blood levels: an interview with Dr. Harvey Kaufman

What is LDL cholesterol? What blood level of LDL cholesterol is considered optimal and why are high levels of LDL cholesterol a key marker of death risk from heart disease? Dr. Harvey Kaufman, senior medical director of Quest Diagnostics gives us some answers.

From Quest Diagnostics 19 Jun 2013

Risk assessment scoring system may help identify adults at risk of developing type 2 diabetes

Researchers have developed a risk assessment scoring system that they believe may better identify certain adults-- especially African Americans-- at high risk of developing type 2 diabetes, heart disease and stroke than does the current system of diagnosing the metabolic syndrome.

19 Jun 2013

Weight-loss surgery may improve metabolic risk factors in obese patients: Study

Among mild to moderately obese patients with type 2 diabetes, adding gastric bypass surgery to lifestyle and medical management was associated with a greater likelihood of improved levels of metabolic risk factors such as blood glucose, LDL-cholesterol and systolic blood pressure, according to a study in the June 5 issue of JAMA.

5 Jun 2013

Study examines efficacy of dietary flaxseed supplementation in management of hypercholesterolemia in children

A study by Helen Wong, R.D., of The Hospital for Sick Children, Ontario, Canada, and colleagues examined the safety and efficacy of dietary flaxseed supplementation in the management of hypercholesterolemia (high levels of cholesterol) in children.

4 Jun 2013

Omthera to be acquired by AstraZeneca

AstraZeneca today announced that it has entered into a definitive agreement to acquire Omthera Pharmaceuticals, a specialty pharmaceutical company based in Princeton, New Jersey, focused on the development and commercialization of new therapies for abnormal levels of lipids in the blood, referred to as dyslipidemia.

28 May 2013

Study reveals that heart disease risk factor management differs among outpatient practices

Control of heart disease risk factors varies widely among outpatient practices, according to a study presented at the American Heart Association's Quality of Care and Outcomes Research Scientific Sessions 2013.

17 May 2013

FDA approves Mylan's ANDA for Fenofibrate Tablets

Mylan Inc. today announced that its subsidiary Mylan Pharmaceuticals Inc. has shipped Fenofibrate Tablets, 48 mg and 145 mg.

17 May 2013

Scientists identify 4 genes in baboons that influence levels of bad cholesterol

Scientists at the Texas Biomedical Research Institute in San Antonio have identified four genes in baboons that influence levels of "bad" cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.

17 May 2013

Scientists reveal inside story of European regulatory review and approval of Glybera

The scientists who led the team that developed Glybera, the first gene therapy drug approved for use in the Western world, provide a fascinating first-person account of their pioneering work in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

16 May 2013

Breathing motor vehicle emissions triggers change in HDL cholesterol

Academic researchers have found that breathing motor vehicle emissions triggers a change in high-density lipoprotein cholesterol, altering its cardiovascular protective qualities so that it actually contributes to clogged arteries.

16 May 2013

Regular marijuana use is associated with favorable indices related to diabetic control, say investigators

Regular marijuana use is associated with favorable indices related to diabetic control, say investigators. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus. Their findings are reported in the current issue of The American Journal of Medicine.

15 May 2013

LDL cholesterol blood level declines found to have abruptly ended in 2008

Decades of declines in LDL cholesterol blood levels, a key marker of death risk from heart disease, abruptly ended in 2008, and may have stalled since, according to a multi-year, national study published in PLOS ONE.

From Quest Diagnostics 14 May 2013

Merck's LIPTRUZET tablets get FDA approval for treatment of elevated LDL cholesterol

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has approved LIPTRUZET (ezetimibe and atorvastatin) tablets for the treatment of elevated low-density lipoprotein cholesterol in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet when diet alone is not enough.

4 May 2013

Doing moderate-intensity physical activity more critical to childhood cardiometabolic health

Researchers have discovered that participation in physical activity of at least moderate intensity is more critical to childhood cardiometabolic health than overall sedentary time.

24 Apr 2013

Lipoprotein News and Research

Further Reading

Gene variant linked with Mediterranean diet pattern prevents stroke

European authorisation of Aegerion Pharmaceuticals' Lojuxta brings hope for HoFH patients

Study leads to new approach for treatment of aortic valve stenosis

Researchers are one step closer to finding solution for atherosclerosis in diabetic patients

Researchers find RNA molecule that interferes with lipoprotein production, reduces hyperlipidemia

Gene switch off may increase risk of heart and blood vessel disease: Research

LDL cholesterol blood levels: an interview with Dr. Harvey Kaufman

Risk assessment scoring system may help identify adults at risk of developing type 2 diabetes

Weight-loss surgery may improve metabolic risk factors in obese patients: Study

Study examines efficacy of dietary flaxseed supplementation in management of hypercholesterolemia in children

Omthera to be acquired by AstraZeneca

Study reveals that heart disease risk factor management differs among outpatient practices

FDA approves Mylan's ANDA for Fenofibrate Tablets

Scientists identify 4 genes in baboons that influence levels of bad cholesterol

Scientists reveal inside story of European regulatory review and approval of Glybera

Breathing motor vehicle emissions triggers change in HDL cholesterol

Regular marijuana use is associated with favorable indices related to diabetic control, say investigators

LDL cholesterol blood level declines found to have abruptly ended in 2008

Merck's LIPTRUZET tablets get FDA approval for treatment of elevated LDL cholesterol

Doing moderate-intensity physical activity more critical to childhood cardiometabolic health

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