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AI-designed drug ISM5939 granted IND clearance for cancer clinical trials

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors.

22 Nov 2024

New study unveils why glioblastoma becomes resistant to treatment

A new study from scientists at the UCLA Health Jonsson Comprehensive Cancer Center helps explain why glioblastoma, one of the most aggressive forms of brain cancer, becomes resistant to treatment, and introduces a new approach that paves the way for more personalized treatment strategies for patients with this deadly brain tumor.

22 Nov 2024

Researchers develop efficient approach for designing custom proteins

Protein design aims to create customized antibodies for therapies, biosensors for diagnostics, or enzymes for chemical reactions.

22 Nov 2024

AI models redefine TIL scoring in breast cancer but face challenges in real-world validation

AI models analyzing tumor-infiltrating lymphocytes show promise in predicting outcomes for triple-negative breast cancer, but external validation reveals critical performance gaps.

21 Nov 2024

Predicting mood episodes with sleep data: A breakthrough for mental health care

Researchers developed a machine-learning model that uses only sleep-wake patterns to predict mood episodes in patients with mood disorders, achieving high accuracy. This approach simplifies real-world mental health monitoring using data from wearables or smartphones.

21 Nov 2024

Exploring how biological clocks measure aging and predict mortality

This review was published by Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), in Volume 16, Issue 17, titled, "A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans."

21 Nov 2024

AI could detect Parkinson's disease by analyzing subtle changes in voice

Algorithms that can detect subtle changes in a person's voice are emerging as a potential new diagnostic tool for Parkinson's disease, according to researchers from Iraq and Australia.

21 Nov 2024

Researchers develop low cost, scalable methodology for early dementia detection

A new study by researchers from Regenstrief Institute, Indiana University and Purdue University presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia.

20 Nov 2024

NIH develops AI algorithm to streamline clinical trial matching

Researchers from the National Institutes of Health (NIH) have developed an artificial intelligence (AI) algorithm to help speed up the process of matching potential volunteers to relevant clinical research trials listed on ClinicalTrials.gov.

18 Nov 2024

Innovative platform helps explore genetic links to 99 diseases

A new study introduces the Proteome-Wide Association Study Hub, an innovative and powerful tool designed to explore gene-disease connections across ninety-nine common diseases.

18 Nov 2024

EASI algorithm set to transform forensic drug identification processes

Relief is coming for crime scene investigators and toxicologists who have struggled to accurately and swiftly identify drugs that have been seized by law enforcement and may be relied on as evidence at trial, thanks to a research partnership between West Virginia University and the U.S. Drug Enforcement Administration.

15 Nov 2024

Evo model set to transform synthetic biology and disease diagnosis

A new study presents "Evo" – a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo's ability to predict, generate, and engineer entire genomic sequences could change the way synthetic biology is done.

15 Nov 2024

Nanowire-based technology detects cancer-associated miRNAs in urine

Cancer has a high death rate with delayed diagnosis of the disease being one of the main reasons for its fatality.

15 Nov 2024

Microbial density in our gut shapes how diseases are linked to gut health

The study in Cell highlights microbial load's role in gut microbiome variation, suggesting it as a confounder in disease research and a key health determinant.

15 Nov 2024

Futuristic AI-powered virtual lab designs potent SARS-CoV-2 nanobodies

AI-human collaboration in a "Virtual Lab" successfully designs and experimentally validates nanobodies with enhanced binding to SARS-CoV-2 variants, offering a novel approach to interdisciplinary research.

14 Nov 2024

Study links heart shape to genetic risk of cardiovascular diseases

A new multi-national study has revealed that the shape of the heart is influenced in part by genetics and may help predict the risk of cardiovascular diseases.

14 Nov 2024

Deep learning AI model outperforms humans in identifying pathologies

A "deep learning" artificial intelligence model developed at Washington State University can identify pathology, or signs of disease, in images of animal and human tissue much faster, and often more accurately, than people.

14 Nov 2024

Update on diagnosis, risk classification and treatment of Kawasaki Disease

Advances in cardiac imaging techniques and risk categorization have led to improvements in diagnosis, initial treatment and long-term management of patients with Kawasaki Disease, according to a new scientific statement published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

14 Nov 2024

Innovative urine test could improve pancreatic cancer survival rates

Innovative urinary miRNA profiling shows potential for early pancreatic cancer detection, with high accuracy and sensitivity, transforming screening practices.

14 Nov 2024

Study shows how microbial load affects gut health and disease

In sickness or in health, the billions of microorganisms that inhabit our guts are our constant companions throughout life. In the past few decades, scientists have shown how the nature of this 'microbiome' can provide valuable clues to human diseases and their treatment.

14 Nov 2024