Transplant News and Research

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Newborn screening for "bubble-baby" disease boosts survival of children

Screening newborns for severe combined immunodeficiency disease (SCID) significantly increases the survival of children after bone marrow transplantation, a new North American study finds.

21 Jun 2023

Single mutation of the hepatitis E virus stands in the way of sofosbuvir drug's effectiveness

A single mutation stands in the way of a drug's effectiveness. Understanding it helps find new therapeutic approaches.

21 Jun 2023

Newborn screening facilitates early identification of infants with severe combined immunodeficiency

Introducing widespread screening of newborns for a deadly disease called severe combined immunodeficiency, or SCID, followed by early treatment boosted the five-year survival rate of children with the disorder from 73% before the advent of screening to 87% since, researchers report.

20 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

Unlocking the secret to lifelong health: the power of optimal immune resilience

Researchers assessed immune resilience (IR) metrics in individuals across diverse infectious and non-infectious models.

15 Jun 2023

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

15 Jun 2023

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

A study led by researchers at the Garvan Institute of Medical Research shows for the first time how a gene called RELA, known to regulate inflammation, also plays an essential role in maintaining normal blood-sugar levels.

14 Jun 2023

Understanding the developmental link: vitamin D's role in metabolic disease risk

Study showed that transplanting fetal hematopoietic stem cells exposed to vitamin D deficiency induces diabetes.

14 Jun 2023

Immune resilience promotes longevity and resistance to infections

Researchers from The University of Texas Health Science Center at San Antonio, working with collaborators in five countries, today revealed that the capacity to resist or recover from infections and other sources of inflammatory stress - called "immune resilience" - differs widely among individuals.

13 Jun 2023

Researchers develop protein biomarker panels to predict developmental dysplasia of the hip

Researchers from the University of Missouri School of Medicine have developed panels of protein biomarkers present in teens and young adults that distinguish individuals with healthy hips from those with developmental dysplasia of the hip, also known as hip dysplasia, which often progresses to hip osteoarthritis if not recognized before early adulthood.

13 Jun 2023

Vitamin D deficiency during pregnancy linked to an increased risk of Type 2 diabetes in offspring

Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of Type 2 diabetes in offspring.

13 Jun 2023

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

“List diving” contributes to disparities in organ transplantation

A kidney from a deceased donor is supposed to be allocated to the top-ranked patient on a transplant center's waiting list, identified using an objective algorithm to rank patients based on patient age, waiting time, and other factors.

8 Jun 2023

New scientific statement details treatment strategies for pediatric cardiomyopathy

Treating children with cardiomyopathy should be personalized based on the root cause, symptoms and progression of the condition in each child , according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

8 Jun 2023

Life-changing procedure using new aortic valve device clears way for patient in need of liver transplant and hip replacement

Janice Couch, 62, a retired pre-school teacher from Grand Rapids, Michigan, is finally physically ready to receive two procedures that stand to change her life, thanks to Henry Ford Health interventional cardiologists who paved the way by implanting a new aortic valve device for the first time in the health system's history.

6 Jun 2023

Kidneys from donors with COVID-19 not associated with organ rejection, complications after transplant

Researchers at Washington University School of Medicine in St. Louis have found that donated kidneys from deceased COVID-19 patients are safe to transplant.

5 Jun 2023

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

5 Jun 2023

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

At the 2023 American Society for Clinical Oncology Annual Meeting—to be held June 2-6 in Chicago, Illinois—Fred Hutchinson Cancer Center experts will present research spanning survivorship, advances in treatments and clinical trials, how access to cancer care affects outcomes, integrative medicine and more.

5 Jun 2023

Testing for dangerous 'zombie' cells could increase the number of donor hearts for transplant

Testing older potential organ donors for dangerous 'zombie' cells could help to increase the number of hearts available for transplant, according to research part-funded by the British Heart Foundation (BHF) and presented at the British Cardiovascular Society conference in Manchester.

4 Jun 2023

Experimental decoy provides long-term protection from SARS-Cov-2 infection

An experimental "decoy" provided long-term protection from infection by the pandemic virus in mice, a new study finds.

30 May 2023

Transplant News and Research

Newborn screening for "bubble-baby" disease boosts survival of children

Single mutation of the hepatitis E virus stands in the way of sofosbuvir drug's effectiveness

Newborn screening facilitates early identification of infants with severe combined immunodeficiency

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Unlocking the secret to lifelong health: the power of optimal immune resilience

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

Understanding the developmental link: vitamin D's role in metabolic disease risk

Immune resilience promotes longevity and resistance to infections

Researchers develop protein biomarker panels to predict developmental dysplasia of the hip

Vitamin D deficiency during pregnancy linked to an increased risk of Type 2 diabetes in offspring

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

“List diving” contributes to disparities in organ transplantation

New scientific statement details treatment strategies for pediatric cardiomyopathy

Life-changing procedure using new aortic valve device clears way for patient in need of liver transplant and hip replacement

Kidneys from donors with COVID-19 not associated with organ rejection, complications after transplant

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

Testing for dangerous 'zombie' cells could increase the number of donor hearts for transplant

Experimental decoy provides long-term protection from SARS-Cov-2 infection

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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