B Cell News and Research

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How does tirzepatide stimulate insulin secretion?

Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control insulin secretion and energy balance, Duke Health researchers report.

6 Jun 2023

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Researchers describe the Treg-cell-inducing activity of lipid extracts from the feces of specific-pathogen-free mice.

6 Jun 2023

Large-scale comprehensive sequencing helps downstream medical care in newborns

Researchers who lead the world's first comprehensive sequencing program for newborn infants have published the next chapter in the ongoing study of the BabySeq Project, with new findings on infants and families who have been followed for 3-5 years.

6 Jun 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide - with almost a third in the United States - are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

Protecting the heart during menopausal transition may help protect brain health

The research, published in the journal Alzheimer's & Dementia, is further evidence that the menopause transition is a particularly important time for women and their doctors to pay attention to heart health, in turn protecting their brain health.

5 Jun 2023

Study assesses the safety, efficacy of using immune checkpoint inhibitors in patients with advanced kidney cancer

Patients with advanced kidney cancer are routinely given immune checkpoint inhibitors (ICIs) as first-line treatment.

5 Jun 2023

HER2-targeted antibody drug conjugate shows encouraging responses, long-lasting clinical benefit in several tumor types

In a new study of trastuzumab deruxtecan, a HER2-targeted antibody drug conjugate, researchers observed encouraging responses and long-lasting clinical benefit in several tumor types.

5 Jun 2023

Understanding the possible mechanisms of myocardial injury in patients with COVID-19

Announcing a new article publication for Cardiovascular Innovations and Applications journal.

5 Jun 2023

New pangenome reference could deepen our understanding of human biology and disease

The first human genome, which has served as the reference until now, was released approximately 20 years ago.

5 Jun 2023

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

5 Jun 2023

New insights into the importance of microglia in controlling anxiety-related behaviors

The pandemic and its aftermath have raised anxiety to new levels. But the roots of anxiety-related conditions, including obsessive-compulsive spectrum disorder (OCSD), are still unclear.

5 Jun 2023

Study provides a treasure trove of information on molecular biology of the immune system

Researchers at Sanford Burnham Prebys, collaborating with scientists from Eli Lilly and Company, have revealed the structure and function of a drug called LY3361237, which can reduce the harmful activity of the immune system to help treat autoimmune diseases.

5 Jun 2023

Scientists develop AI-based method to visualize and track changes in the strength of synapses

Johns Hopkins scientists have developed a method involving artificial intelligence to visualize and track changes in the strength of synapses — the connection points through which nerve cells in the brain communicate — in live animals.

5 Jun 2023

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Researchers described a novel strategy for controlling severe acute respiratory syndrome coronavirus 2.

5 Jun 2023

Expertise in cancer treatment could be used to find a cure for endometriosis

Endometriosis: If we utilize all the knowledge we have about cancer, there is reason to hope that effective diagnosis and treatments can be developed to combat the female condition 'everybody' is talking about.

5 Jun 2023

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

At the 2023 American Society for Clinical Oncology Annual Meeting—to be held June 2-6 in Chicago, Illinois—Fred Hutchinson Cancer Center experts will present research spanning survivorship, advances in treatments and clinical trials, how access to cancer care affects outcomes, integrative medicine and more.

5 Jun 2023

Gene alterations in biliary tract cancer offer potential targets for effective precision therapies

Gene alterations in biliary tract cancer offer potential targets for current or future precision therapies. This is demonstrated by a highly acclaimed study conducted by Karl Landsteiner University of Health Sciences in collaboration with the Medical University of Vienna.

5 Jun 2023

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

A ground-breaking study by Loughborough University and the University of Oxford has led to the development of a small molecule probe that could deepen our understanding of a crucial cellular messenger and lead to the development of new therapeutic drugs.

5 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

UVA discoveries highlight the different roles of blood vessels in solid tumors

Two new discoveries from the Dudley lab at UVA Cancer Center highlight the different roles of blood vessels in solid tumors – and the findings could help prevent breast cancer from spreading and enhance the effectiveness of one of the most important new cancer treatments in many years.

4 Jun 2023

B Cell News and Research

How does tirzepatide stimulate insulin secretion?

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Large-scale comprehensive sequencing helps downstream medical care in newborns

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

Protecting the heart during menopausal transition may help protect brain health

Study assesses the safety, efficacy of using immune checkpoint inhibitors in patients with advanced kidney cancer

HER2-targeted antibody drug conjugate shows encouraging responses, long-lasting clinical benefit in several tumor types

Understanding the possible mechanisms of myocardial injury in patients with COVID-19

New pangenome reference could deepen our understanding of human biology and disease

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

New insights into the importance of microglia in controlling anxiety-related behaviors

Study provides a treasure trove of information on molecular biology of the immune system

Scientists develop AI-based method to visualize and track changes in the strength of synapses

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Expertise in cancer treatment could be used to find a cure for endometriosis

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

Gene alterations in biliary tract cancer offer potential targets for effective precision therapies

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

UVA discoveries highlight the different roles of blood vessels in solid tumors

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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