Efficacy News and Research

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New lipid derivatives of Remdesivir have higher anti-coronavirus activity

In a fascinating new preprint paper published on bioRxiv* in August 2020, the researchers report “the synthesis and antiviral evaluation of three novel lipophilic prodrugs of RVn-monophosphate that are substantially more active than Remdesivir in cells infected with SARS-CoV-2.” These could be of immense use in treating COVID-19 patients early and helping to end transmission.

30 Aug 2020

Using SARS-CoV-2 epitope to construct a vaccine

A new study published on the preprint server bioRxiv* in August 2020 reports the use of prediction and advanced simulation techniques to identify a novel T cell epitope on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could serve as the basis for a customized vaccine with broad-based efficacy.

30 Aug 2020

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

However, the nucleocapsid (N) protein is also extremely abundant and, therefore, a useful target for both vaccine and diagnostic test development. A new study published on the preprint server bioRxiv in August 2020 reveals the structure of this protein, a valuable step in using it for these purposes.

30 Aug 2020

Scientists describe known approaches for treatment of SARS-CoV-2 infection

Researchers from Sechenov University together with Russian and Iranian colleagues described currently known approaches to the treatment of SARS-CoV-2 infection.

29 Aug 2020

Manipulating 3D Printed Organoid Microenvironments

Organoids are 3-dimensional (3D) clusters of stem cells that come together and emulate the microenvironment within individual organs, whether that be liver, kidney, heart, gut or other specific organs.

From Manchester BIOGEL 28 Aug 2020

Study shows how genetics could improve safety and efficacy of drugs for COVID-19 treatment

Over the past few months, a number of drugs have been under investigation to treat COVID-19 without well-established safety or data to support these claims.

28 Aug 2020

CBASP model can be effective for treating persistent depressive disorder

Persistent depressive disorder (PDD) is very common and debilitating, but only few therapeutic options exist that target this form of depression.

28 Aug 2020

Researchers discover how brain cancer cells evade the body's immune system

Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body's immune system.

27 Aug 2020

Long-term brain monitoring technologies can benefit epilepsy patients

Today, the way a physician gets an idea of how many seizures a person with epilepsy has had is through the patient's own record of seizure activity in his day-to-day life.

27 Aug 2020

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation.

27 Aug 2020

New approach to combination drug design could be applied to disease therapies beyond diabetes

Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered.

27 Aug 2020

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

The COVID-19 pandemic is still creating economic and health-related impact over the world. A new study published on the preprint server bioRxiv in August 2020 shows that a gp96-Ig-secreting vaccine candidate based on the expression of full-length spike protein generates a potent T cell response.

26 Aug 2020

Scientists combine 3D bioprinting and computer modeling to study cancer metastasis in blood vessels

Lawrence Livermore National Laboratory scientists have paired 3D-printed, living human brain vasculature with advanced computational flow simulations to better understand tumor cell attachment to blood vessels, the first step in secondary tumor formation during cancer metastasis.

26 Aug 2020

New method analyzes the whole brain network for the first time

A new method of brain imaging analysis offers the potential to greatly improve the effectiveness of noninvasive brain stimulation treatment for Alzheimer's, obsessive compulsive disorder, depression, and other conditions.

26 Aug 2020

Inhaled steroid ciclesonide suppresses SARS-CoV-2 replication in vitro

A new paper by researchers at Japan’s National Institute of Infectious Diseases and published on the preprint server bioRxiv in August 2020 reports the in vitro suppression of coronavirus (CoV) replication by an inhaled corticosteroid (ICS) ciclesonide.

26 Aug 2020

Study: COVID-19 vaccine should be at least 80% effective to prevent ongoing pandemic

The American Journal of Preventive Medicine, published by Elsevier, is committed to publishing the most robust, evidence-based research and commentary on COVID-19 as they unfold to keep readers up to date and aware of issues relevant to community and individual health during this continually evolving global outbreak.

26 Aug 2020

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

In May 2019, the U.S. Food and Drug Administration approved a gene replacement therapy for the inherited, progressive neuromuscular disease 5q-linked spinal muscular atrophy.

25 Aug 2020

Monoclonal antibodies may be a better choice than convalescent plasma for treating COVID-19

A team of researchers from the Netherlands demonstrated that prophylactic treatment with a high dose of human convalescent plasma or by using concentrated monoclonal antibodies could protect against disease following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an animal model. However, no protective effect was observed with a ten-fold lower dose of convalescent plasma. The results are currently available on the bioRxiv* preprint server.

25 Aug 2020

Researchers discover new genes that influence cancer treatment success

One of the great mysteries of cancer research is why certain patients respond better to radiation therapy than others. Researchers at the University of Bern have now discovered which genes play an important role in this. This results in new findings for cancer treatment.

25 Aug 2020

Hydroxychloroquine treatment for COVID-19 patients lowers in-hospital mortality rates

An Italian observational study contributes to the ongoing debate regarding the use of hydroxychloroquine in the current pandemic.

25 Aug 2020

Efficacy News and Research

New lipid derivatives of Remdesivir have higher anti-coronavirus activity

Using SARS-CoV-2 epitope to construct a vaccine

SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated

Scientists describe known approaches for treatment of SARS-CoV-2 infection

Manipulating 3D Printed Organoid Microenvironments

Study shows how genetics could improve safety and efficacy of drugs for COVID-19 treatment

CBASP model can be effective for treating persistent depressive disorder

Researchers discover how brain cancer cells evade the body's immune system

Long-term brain monitoring technologies can benefit epilepsy patients

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

New approach to combination drug design could be applied to disease therapies beyond diabetes

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

Scientists combine 3D bioprinting and computer modeling to study cancer metastasis in blood vessels

New method analyzes the whole brain network for the first time

Inhaled steroid ciclesonide suppresses SARS-CoV-2 replication in vitro

Study: COVID-19 vaccine should be at least 80% effective to prevent ongoing pandemic

Study examines safety and early outcomes of gene therapy for spinal muscular atrophy

Monoclonal antibodies may be a better choice than convalescent plasma for treating COVID-19

Researchers discover new genes that influence cancer treatment success

Hydroxychloroquine treatment for COVID-19 patients lowers in-hospital mortality rates

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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