Therapy News and Research

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STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Achieving a good efficacy of chemotherapy is one of the major challenges still unresolved in oncological patients. The main limitation to the efficacy of chemotherapy is the multidrug-resistant (MDR) phenotype, a multiple cross-resistance towards different anticancer drugs.

14 Sep 2022

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration.

14 Sep 2022

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

In a new study, researchers explored the genetic risk factors associated with various diseases to understand their impact on healthy life years.

14 Sep 2022

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

A new study describes the changes in immune T cell profile over time following monkeypox infection.

14 Sep 2022

Study estimates the cost-effectiveness of therapeutic alternatives

Giving standard chemotherapy drugs in a specific sequence for some types of metastatic breast cancer can help reduce overall costs and improve the value of care while preserving quality of life, according to a study led by UNC Lineberger Comprehensive Cancer Center and UNC Gillings School of Global Public Health researchers.

14 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Manuka honey could cure serious lung infections caused by drug-resistant bacterium

In a recent study published in the journal Microbiology, researchers demonstrated that incorporating Manuka honey into nebulized antibiotic treatment could effectively combat respiratory infections due to Mycobacterium abscessusus, offering a novel new therapeutic strategy for M. abscessus management.

13 Sep 2022

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Researchers at Oregon State University and Oregon Health & Science University have developed a promising, first-of-its-kind messenger RNA therapy for ovarian cancer as well as cachexia, a muscle-wasting condition associated with cancer and other chronic illnesses.

13 Sep 2022

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

In an article published in the journal Expert Opinion on Drug Safety, scientists have described the safety and efficacy profiles of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies in pregnant women with coronavirus disease 2019 (COVID-19).

13 Sep 2022

New drug marks cancer cells for destruction by the immune system

Tumor cells are notoriously good at evading the human immune system; they put up physical walls, wear disguises and handcuff the immune system with molecular tricks.

13 Sep 2022

Researchers use data from wearables to predict outcomes of depression treatment

Over the past several years, managing one's mental health has become more of a priority with an increased emphasis on self-care. Depression alone affects more than 300 million people worldwide annually.

13 Sep 2022

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" - a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

Maintaining a regular workout routine can help you look and feel great – but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening of the muscles and bones, a condition known as locomotor frailty.

13 Sep 2022

Final results of the PATHFINDER study by GRAIL on multi-cancer early detection tests announced

A new press release announced the results of their interventional PATHFINDER study on the early detection of cancer using multi-cancer early detection (MCED) blood tests.

13 Sep 2022

What is the effectiveness of tecovirimat for treatment of monkeypox?

Researchers assessed the effectiveness of tecovirimat in monkeypox treatment in a new study.

13 Sep 2022

Immunotherapy before surgery improves outcomes in many patients with stage II–IV cutaneous squamous cell carcinoma

In an international, multicenter Phase II clinical trial led by The University of Texas MD Anderson Cancer Center, 63.3% of patients with stage II–IV cutaneous squamous cell carcinoma (CSCC) saw their tumors nearly or completely disappear when treated with immunotherapy before surgery.

13 Sep 2022

Trastuzumab deruxtecan treatment maintains quality of life in HER2-low metastatic breast cancer patients

Patients who received trastuzumab deruxtecan (T-DXd) for human epidermal growth factor receptor 2 (HER2)-low metastatic breast cancer reported that the treatment maintained their quality of life (QoL) compared to conventional chemotherapy, according to results presented today by researchers from The University of Texas MD Anderson Cancer Center at the European Society for Medical Oncology Congress 2022.

13 Sep 2022

$Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer$

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer.

13 Sep 2022

The maternal and perinatal outcomes of pregnancies complicated by monkeypox infection

A new study reviews the available evidence on the impact of monkeypox infection during pregnancy.

13 Sep 2022

Therapy News and Research

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

Study estimates the cost-effectiveness of therapeutic alternatives

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Manuka honey could cure serious lung infections caused by drug-resistant bacterium

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

New drug marks cancer cells for destruction by the immune system

Researchers use data from wearables to predict outcomes of depression treatment

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

Final results of the PATHFINDER study by GRAIL on multi-cancer early detection tests announced

What is the effectiveness of tecovirimat for treatment of monkeypox?

Immunotherapy before surgery improves outcomes in many patients with stage II–IV cutaneous squamous cell carcinoma

Trastuzumab deruxtecan treatment maintains quality of life in HER2-low metastatic breast cancer patients

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

The maternal and perinatal outcomes of pregnancies complicated by monkeypox infection

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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