Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

World's first recipient of insulin-producing cells from a living donor

A 27-year-old diabetic woman has become the world's first recipient of insulin-producing cells from a living donor.

19 Apr 2005

Drugs targeted at muscle cells can be of use in the treatment of diabetes patients with insulin resistance

Type 2 diabetes is a clinical disease characterised by disruption to the metabolism of glucose and lipids as well as to the production of and physiological reactions to insulin.

19 Apr 2005

Study explores parents's reaction to discovering a child has diabetes

Discovering a child has diabetes can be a traumatic and life-changing event for parents and researchers doubt whether many of them ever come to terms with it.

19 Apr 2005

One-meter waistline predicts high risk of diabetes and heart disease

People with a waistline of one meter or more are at serious risk of insulin resistance - an early stage in the development of diabetes and heart disease, finds a study published online by the BMJ.

19 Apr 2005

Rimonabant appears to reduce risk factors for heart disease in obese people

A new drug could substantially reduce the bodyweight, waist circumference, and risk factors for heart disease in obese people, according to results of a randomised trial published in this week’s issue of The Lancet.

19 Apr 2005

Japanese researchers reverse diabetes

Japanese researchers have successfully reversed a woman’s diabetes by transplanting insulinmaking cells (islets) from a living donor’s pancreas into her, reporting their results in a research letter published online today by The Lancet. This is the first successful operation of its kind using the islets from a living donor.

19 Apr 2005

Scientists use transcription factors to increase insulin production in diabetic mice

A group of Japanese scientists has used gene therapy to deliver three insulin transcription factors, MafA, PDX-1, and NeuroD, to the livers of diabetic mice. As a result, the mice experienced an increase in insulin gene expression and insulin production, raising the possibility that this could eventually be used to treat diabetes.

13 Apr 2005

Breakthough in stem cell research - three clones of cells from existing human embryonic stem cells

In an Australian first, UNSW researchers have developed three clones of cells from existing human embryonic stem cells. The breakthrough could lead to new treatments for conditions such as diabetes, Parkinson’s disease and spinal cord injury.

13 Apr 2005

New findings about insulin-signaling in the liver could prove useful in understanding type 2 diabetes

A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.

12 Apr 2005

Obesity linked to diabetes

A research team headed by Professor Helena Edlund at Umeå University has achieved a breakthrough in our understanding of how obesity causes increased levels of insulin, sugar, and blood fats leading to diseases like type-2 diabetes and liver degeneration. The findings also indicate a direct way to prevent these diseases.

12 Apr 2005

Protein that regulates cholesterol levels may lead to new drug targets in the fight against obesity

A protein that regulates cholesterol levels in the body also is responsible for maintaining a healthy balance between fat storage and fat burning, according to a UT Southwestern Medical Center study that may lead to new drug targets in the fight against obesity.

12 Apr 2005

Researcher grows new insulin-secreting beta cells from pancreatic tissue

JDRF-funded researchers in Canada and Massachusetts have stimulated the birth of new insulin-secreting beta cells by treating human islets with a mixture of two naturally occurring peptides: epidermal growth factor (EGF) and gastrin.

12 Apr 2005

Disability tax credit benefits Canadians with diabetes

Some Canadians who use insulin to manage their diabetes may be eligible for a federal tax credit worth up to $1,055 when they file their 2005 tax returns next year, the Canadian Diabetes Association announced recently.

12 Apr 2005

Cardiovascular disease: diet, nutrition and emerging risk factors

Despite improvements in death rates from cardiovascular disease (CVD) around the world, CVD remains a leading cause of death and ill health in the UK, where death rates are amongst the highest in the world. Reducing death rates from this disease remains high on the Government’s agenda, yet attention to the classical risk factors may not provide all the answers.

12 Apr 2005

Tissue engineering to grow bone, ligaments and cartilage

A future in which laboratory-grown organs and stimulated growth of muscle, bones and nerves could play a major role in treating medical conditions was revealed at a recent Tissue Engineering Symposium at Wake Forest University Baptist Medical Center.

11 Apr 2005

Polycystic ovary syndrome increases chance of developing cardiovascular disease

Women who suffer from polycystic ovary syndrome (PCOS), one of the most common causes of female infertility in the U.S., have an increased chance of developing cardiovascular disease, according to a new study published this month in The Journal of Clinical Endocrinology & Metabolism, published by The Endocrine Society.

6 Apr 2005

Almonds may help combat obesity, heart disease and diabetes

Three studies presented during this week's 2005 Experimental Biology conference add to the growing body of research that eating just a handful of almonds may be a valuable tool to combat some of America's leading health threats, including obesity, heart disease and diabetes.

6 Apr 2005

Alteration of steroid receptor genes creates fat burning muscle

The Salk Institute scientist who earlier discovered that enhancing the function of a single protein produced a mouse with an innate resistance to weight gain and the ability to run a mile without stopping has found new evidence that this protein and a related protein play central roles in the body's complex journey to obesity and offer a new and specific metabolic approach to the treatment of obesity related disease such as Syndrome X (insulin resistance, hyperlipidemia and atherosclerosis).

4 Apr 2005

New trial for treatment of liver disease

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network is launching its first two clinical trials for the study of NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol.

3 Apr 2005

Pediatric burn victims’ recovery, diabetes aided by Fenofibrate

One of the immediate serious results of sudden extreme trauma or stress, including burns and even surgery, is insulin resistance, or diabetes. As a result, healing is delayed, especially in the case of severe burns, and since the body is unable to fully use blood sugar for energy, muscle tissue is broken down as the body scavenges for other possible energy sources.

3 Apr 2005