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Head-to-head comparison of three breast cancer drugs reveals important differences

Every year, more than 250,000 women in the U.S. are diagnosed with breast cancer. When detected early, patients with the most common form--which tests positive for hormone receptors (HR+) and negative for the HER2 receptor--usually respond well to treatment.

23 Aug 2019

Super-powered immune cells to attack tumors

Ground-breaking immune therapy promises to deliver vital evidence in the fight against cancer as researchers from the Centre for Cancer Biology open a new clinical trial using genetically engineered immune cells to treat solid cancers.

23 Aug 2019

Unraveling the secret itch pathway

Itching is among the most persistent of skin sensations, requiring an immediate response. However, scientists say it is a protective sensation that stimulates the individual to eliminate parasites and other irritating substances from the skin.

23 Aug 2019

Researchers take important step towards preventing cancer metastasis

Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers.

23 Aug 2019

UC San Diego researchers identify new therapeutic approach to kill cancer cells

Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic.

22 Aug 2019

Study opens up a new way for developing potential glioblastoma treatment

A team led by Texas A&M University's College of Veterinary Medicine & Biomedical Sciences' researcher Dr. Stephen Safe has discovered a new pathway that may help suppress the development of glioblastoma tumors, one of the deadliest forms of cancer.

22 Aug 2019

Research explains why many psychiatric drugs that work in the lab don’t work in people

Current drug development for neuropsychiatric disorders is in crisis, say experts. More than 90 percent of all drugs that are developed for illnesses like schizophrenia, depression, Alzheimer’s disease (AD), or the brain tumor glioblastoma complete successful trials in mice but then come to a grinding halt in human trials, wasting billions of dollars in drug research. This is partly because of obvious behavioral differences between the two species.

22 Aug 2019

International study identifies new drug target for treating glioblastoma

A new international study co-led by Cleveland Clinic has identified a new drug target for treating glioblastoma. This target is part of a never-before defined cellular pathway found to contribute to the spread and proliferation of a dangerous subset of cancer cells, called glioma stem cells.

22 Aug 2019

New circulating immune cell could help predict type 1 diabetes risk

A new Finnish study suggests that type 1 diabetes may in part be caused by a novel subset of immune cells. This is because these cells, called peripheral T helper cells, are found to circulate at a higher rate in children with type 1 diabetes of recent onset, as well as in healthy children who later develop the condition.

20 Aug 2019

Dacomitinib treatment for lung cancer increases overall survival but has more side effects

Since its approval in April 2019, dacomitinib has been available for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor activating mutations.

20 Aug 2019

Researchers identify compounds that influence time to sexual maturity and lifespan

Every day, people are exposed to myriad chemicals, both natural and synthetic. Some of these compounds may affect human physical development, but testing them directly on people would be grossly unethical.

20 Aug 2019

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Brain metastases are among the deadliest tumor metastases, with a median survival period of less than one year, and the incidence of brain metastasis is rising.

20 Aug 2019

Lipid signaling pathway may enhance T cell-mediated immunotherapy

The immune system surveils our body looking for things that don't belong, often bacteria and viruses. While cancer cells are abnormal cells that undergo unregulated cell growth, they are good at evading detection by the immune system.

19 Aug 2019

Researchers find biological system that manages cells' response to opioid drug exposure

A team at Scripps Research in Florida has discovered a biological system that manages cells' response to opioid drug exposure. The unexpected discovery offers new ideas for improving the safety of the one of the most effective, and most abused, group of pain medications.

19 Aug 2019

Molecular mechanism of enterovirus infection uncovered

Researchers from the Nanoscience Center at the University of Jyväskylä in collaboration with those at the University of Helsinki have found that body proteins called albumin and certain ions within the attacked host cells can affect the genetic workings of enteroviruses and enhance their infection.

19 Aug 2019

FDA approves novel device to treat symptoms associated with advanced heart failure

The U.S. Food and Drug Administration today approved the Barostim Neo System for the improvement of symptoms in patients with advanced heart failure who are not suited for treatment with other heart failure devices, such as cardiac resynchronization therapy.

18 Aug 2019

Simple technique to choose the sex of offspring by separating X and Y sperm

A simple, reversible chemical treatment can segregate X-bearing sperm from Y-bearing sperm, allowing dramatic alteration of the normal 50/50 male/female offspring ratio, according to a new study by Masayuki Shimada and colleagues at Hiroshima University, published on August 13 in the open-access journal PLOS Biology. The study was performed in mice, but the technique is likely to be widely applicable to other mammals as well.

From PLOS ONE 16 Aug 2019

Receptor News and Research

Head-to-head comparison of three breast cancer drugs reveals important differences

Super-powered immune cells to attack tumors

Unraveling the secret itch pathway

Researchers take important step towards preventing cancer metastasis

UC San Diego researchers identify new therapeutic approach to kill cancer cells

Study opens up a new way for developing potential glioblastoma treatment

Research explains why many psychiatric drugs that work in the lab don’t work in people

International study identifies new drug target for treating glioblastoma

New circulating immune cell could help predict type 1 diabetes risk

Dacomitinib treatment for lung cancer increases overall survival but has more side effects

Researchers identify compounds that influence time to sexual maturity and lifespan

Study: Blocking inflammatory pathway could prevent melanoma brain metastasis

Lipid signaling pathway may enhance T cell-mediated immunotherapy

Researchers find biological system that manages cells' response to opioid drug exposure

Molecular mechanism of enterovirus infection uncovered

FDA approves novel device to treat symptoms associated with advanced heart failure

Simple technique to choose the sex of offspring by separating X and Y sperm

Researchers gain new insights into the mechanism of vaccine-induced T cell immunity

Roswell Park receives more than $15 million in grants for cancer research

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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