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Defensosomes versus COVID-19

In a recent study published in the journal PLoS Biology, researchers investigated the role of angiotensin-converting enzyme 2 (ACE2)-containing defensive exosomes, or 'defensosomes' against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Sep 2022

Large molecules glom together into dense droplets to create squishy circuits in cells

An emerging field explores how groups of molecules condense together inside cells, the way oil droplets assemble and separate from water in a vinaigrette.

14 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Researchers identified type 3 vaccine-derived poliovirus (VDPV) in an infant.

13 Sep 2022

$Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer$

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer.

13 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Interferon response induced by Omicron BA.1 and BA.5 prevents influenza A infection

In a recent study posted to the bioRxiv* preprint server, researchers in Germany and the United Kingdom investigated the interferon responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant and SARS-CoV-2 Omicron sub-variants BA.1 and BA.5, and their efficacy in protecting cells from influenza A virus super-infection.

12 Sep 2022

Triplet therapy slows progression of advanced kidney cancer

A targeted kinase inhibitor added to a two-drug immunotherapy combination slowed the progression of advanced kidney cancer in previously untreated patients, according to research led by an oncologist from Dana-Farber Cancer Institute.

8 Sep 2022

Researchers review the epidemiology, clinical character, treatment, and prevention of human monkeypox

Researchers reviewed the epidemiology, clinical character, treatment, and prevention of human monkeypox.

8 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Announcing a new article publication from Acta Pharmaceutica Sinica B. Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies.

5 Sep 2022

Exploring the muscle symptoms associated with statin therapy

In a new study, investigators explored the influences of statin treatment on muscle symptoms.

31 Aug 2022

Leukemia drug successfully disrupts HER2-positive brain metastasis in animal studies

In animal studies led by researchers at Duke Cancer Institute, a drug approved to treat leukemia successfully disrupted the ability of HER2-positive breast cancer tumors from colonizing the brain.

30 Aug 2022

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Researchers identify and characterize the targets of Vit D on COVID-19 and osteoporosis.

30 Aug 2022

AI can detect Parkinson’s from nighttime breathing patterns

Researchers develop an artificial intelligence-based model to detect Parkinson’s disease and track its progression from nocturnal breathing signals.

25 Aug 2022

Researchers report large molecular compounds and nanoscale nanozyme of two traditional Chinese medicines may inhibit COVID-19 signaling

Researchers investigated the potential anti-COVID-19 activity of traditional Chinese medicine.

25 Aug 2022

Kinase News and Research

Defensosomes versus COVID-19

Large molecules glom together into dense droplets to create squishy circuits in cells

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Blocking FNDC5 prevents cancer-induced cachexia in mice

Interferon response induced by Omicron BA.1 and BA.5 prevents influenza A infection

Triplet therapy slows progression of advanced kidney cancer

Researchers review the epidemiology, clinical character, treatment, and prevention of human monkeypox

Auranofin inhibits SARS-CoV-2 replication

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Exploring the muscle symptoms associated with statin therapy

Leukemia drug successfully disrupts HER2-positive brain metastasis in animal studies

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

AI can detect Parkinson’s from nighttime breathing patterns

Researchers report large molecular compounds and nanoscale nanozyme of two traditional Chinese medicines may inhibit COVID-19 signaling

The risk of adverse reactions when herbal medications are taken with cancer drugs

Researchers assess the cytoprotective activity of nicotine against COVID-19

Scientists begin phase 2 clinical trials of lupus pill

Study contributes to better understanding of the changes in kinase activity in renal cell carcinoma

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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