Small Molecules News and Research

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Researchers make discovery about yeast metabolism that could help drug developers

Researchers at the Francis Crick Institute have developed machine learning algorithms that can predict the metabolism of yeast based on its protein content.

6 Sep 2018

Research team to investigate how blood flow influences formation of plaque

Atherosclerosis - the narrowing of arteries due to plaque buildup - is the underlying reason for the majority of strokes and heart attacks. When atherosclerosis occurs in the arteries that carry blood to the heart muscle, it is called coronary artery disease, the No. 1 killer of Americans.

30 Aug 2018

Study could open new therapeutic avenues to attack herpesviruses

Human cytomegalovirus is a leading cause of birth defects and transplant failures. As it's evolved over time, this virus from the herpes family has found a way to bypass the body's defense mechanisms that usually guards against viral infections. Until now, scientists couldn't understand how it manages to do so.

28 Aug 2018

Protein modifications that indicate disease

Researchers from the University of Zurich can, for the first time, precisely characterize the protein modification ADP-ribosylation for all proteins in a tissue sample.

28 Aug 2018

Study reveals how gene variant affects chronic pain outcomes after trauma

The gene FKBP5 is a critical regulator of the stress response and affects how we respond to environmental stimuli. Previous studies have shown that certain variants of this gene play a role in the development of neuropsychiatric disorders such as posttraumatic stress disorder, depression, suicide risk, and aggressive behavior.

28 Aug 2018

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

CENTOGENE today announced that Evotec AG and CENTOGENE AG entered into a global strategic collaboration agreement for joint drug discovery projects, developing compounds to treat rare genetic diseases.

27 Aug 2018

INRS professors develop innovative strategy to identify leishmanicidal molecules

Leishmania is a microorganism that enters the human body via a sandfly bite. Instead of fleeing the white blood cells deployed by the immune system to destroy it, the parasite allows itself to be swallowed up.

24 Aug 2018

Discovery could lead to new targeted treatment for people with lung cancer

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications.

22 Aug 2018

New tool fills gap in Small Molecules market

This news story covers the launch of SmallMolecules.com, an online tool for scientists looking to buy and compare molecules for their experiments.

From SmallMolecules.com 17 Aug 2018

Researchers discover new promising target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases.

15 Aug 2018

Scientists reveal role of 'junk DNA' in cancer dissemination

The more scientists explore so-called "junk" DNA, the less the label seems to fit.

14 Aug 2018

Researchers produce artificial placenta model that closely resembles natural organ

The placenta has an essential and highly complex task: it must ensure the exchange of important substances between the mother and her unborn child, whilst simultaneously blocking other substances from passing through.

14 Aug 2018

New strategy accelerates, automates process of prototype molecule optimization

The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology.

14 Aug 2018

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

HIV-1 replicates in ninja-like ways. The virus slips through the membrane of vital white blood cells. Inside, HIV-1 copies its genes and scavenges parts to build a protective bubble for its copies.

10 Aug 2018

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Nanoparticles show great promise as diagnostic tools and drug delivery agents. The tiny particles, which scientists can modify with drugs, dyes or targeting molecules, can travel in the circulation and squeeze through small spaces into cells and tissues.

9 Aug 2018

Scientists develop novel peptide drug that could potentially stop development of liver cancer

A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer.

2 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

Small Molecules News and Research

Researchers make discovery about yeast metabolism that could help drug developers

Research team to investigate how blood flow influences formation of plaque

Study could open new therapeutic avenues to attack herpesviruses

Protein modifications that indicate disease

Study reveals how gene variant affects chronic pain outcomes after trauma

Evotec collaborates with CENTOGENE to develop compounds to treat rare genetic diseases

INRS professors develop innovative strategy to identify leishmanicidal molecules

Discovery could lead to new targeted treatment for people with lung cancer

New tool fills gap in Small Molecules market

Researchers discover new promising target point for cancer and diabetes therapies

Scientists reveal role of 'junk DNA' in cancer dissemination

Researchers produce artificial placenta model that closely resembles natural organ

New strategy accelerates, automates process of prototype molecule optimization

Supercomputer simulations reveal potential therapeutic target in HIV-1 replication

Researchers modify nanoparticles to improve their uptake in gastrointestinal tract

Scientists develop novel peptide drug that could potentially stop development of liver cancer

Researchers study how herpesviruses contribute to increased oral inflammation

New approach shows important role of microRNAs in papillomavirus life cycle

New combination approach may help crush resistance to treatment in lung cancer patients

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

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