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Lab-grown tumor organoids predict patient response to CAR T cell therapy

For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time.

9 Dec 2024

Two new subtypes of MASH revealed with different risks and outcomes

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.

9 Dec 2024

Antibody trials show encouraging results in patients with high-risk forms of two blood cancers

Two clinical trials testing the antibody loncastuximab tesirine (Zynlonta) showed encouraging results in patients with high-risk forms of two blood cancers – follicular lymphoma and marginal zone lymphoma.

9 Dec 2024

Post-COVID health risks: Obesity fuels sequelae, smoking hits memory

Obesity significantly increases the risk of post-COVID-19 long-term sequelae, while smoking is primarily linked to memory disorders but does not raise the risk of long COVID symptoms or hospitalization.

9 Dec 2024

Minoxidil found safe and effective for hair loss in breast cancer patients

Hair loss during chemotherapy can cause enough distress for some women to lose self-confidence, which experts say may discourage them from seeking chemotherapy in the first place.

9 Dec 2024

New guidelines developed for the diagnosis and management of premature ovarian insufficiency

New guidelines on the diagnosis and management of premature ovarian insufficiency (POI) – developed by the Centre for Research Excellence in Women's Health in Reproductive Life (CRE-WHiRL) at Monash University, and key international women's health organizations with an international team of experts including women with lived experience – will be published today (TBC) simultaneously in three leading journals.

9 Dec 2024

Simple dietary supplement may provide new approach to boost CAR T cell cancer-fighting power

A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

9 Dec 2024

Hospital-acquired pressure ulcers may hinder neurological recovery in spinal cord injury patients

Research led by The Ohio State University Wexner Medical Center and College of Medicine along with scientists at the Charité – Universitätsmedizin Berlin in Berlin, Germany, provides first evidence that hospital-acquired pressure ulcers are a potent risk factor for poor neurological recovery among patients with acute spinal cord injury (SCI).

9 Dec 2024

New brain stimulation trial aims to improve cognitive recovery from TBI

Traumatic brain injury (TBI) is a leading cause of death and disability among young people in the United States and is the most devastating survivable injury in modern warfare, according to the University of Cincinnati's Ishita Basu.

9 Dec 2024

Breakthrough treatment improves survival rates for children with B-ALL

Just days before his fourth birthday, Santiago was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children.

9 Dec 2024

Pioneering study discovers new genetic links to pancreatic cancer in Brazil

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

Two studies show potential for newborn genetic screening

Two studies published today in the American Journal of Human Genetics show the potential for genomic screening in newborns to address high rates of infant hospitalization and mortality in the United States.

9 Dec 2024

Engineered immune cells could transform treatment for autoimmune diseases

Immune cells that are designed to soothe could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions.

9 Dec 2024

Depression genes amplify women's heart disease risk

Study reveals a sex-specific link between genetic risks for psychiatric disorders and cardiovascular diseases (CVDs), with women showing a higher risk of atrial fibrillation, coronary artery disease, and heart failure linked to genetic predisposition to major depression. Menopause and modifiable factors like BMI and smoking amplify these risks.

8 Dec 2024

Breakthrough discovery in BK polyomavirus replication offers hope for kidney transplant protection

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

6 Dec 2024

Study reveals how DNA folding drives gene activity bursts

Researchers at Kyushu University have revealed how spatial distance between specific regions of DNA is linked to bursts of gene activity.

6 Dec 2024

Vanderbilt University Medical Center receives $7 million to study breathing tube size in critical care

Vanderbilt University Medical Center has been approved for $7 million in research funding by the Patient-Centered Outcomes Research Institute (PCORI) to study the effect of breathing tube size on breathing, speaking and swallowing after critical illness.

6 Dec 2024

Bacterial toxin may fuel colorectal cancer metastasis

A toxin in the bacteria that's one of the most common causes of foodborne illness accelerates the spread of colorectal tumors to other parts of the body, a study led by UF Health Cancer Center researchers and international collaborators has found.

6 Dec 2024

$1.5 million grant supports alternatives to opioids initiative at University Hospitals

A grant of nearly $1.5 million from the Department of Health and Human Services through its Substance Abuse and Mental Health Services Administration (SAMHSA) will enable University Hospitals Cleveland Medical Center to develop and implement an Alternatives to Opioids (ALTO) program within its Emergency Department (ED).

6 Dec 2024

MRI study offers new insights into celiac disease treatment

Experts have used magnetic resonance imaging (MRI) to better understand the impact a gluten free diet has on people with coeliac disease, which could be the first step towards finding new ways of treating the condition.

6 Dec 2024