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New analysis highlights growing trends in combination cancer therapy clinical trials

The Cancer Research Institute, a nonprofit organization dedicated to the discovery and development of powerful immunotherapies for all types of cancer, announced today the publication of its newest analysis of the global landscape of clinical development of drugs that target the PD1/PDL1 immune checkpoint pathway.

10 Feb 2022

KHN’s ‘What the Health?’: FDA takes center stage

The FDA is still lacking a Senate-confirmed leader, but the agency is at the center of several major policy battles. Lawmakers this year must renew the bill that authorizes drug companies to pay "user fees," which enable the agency to hire additional reviewers to speed the approval of drugs.

10 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Researchers investigated the efficacy of two multi-kinase inhibitors, olverembatinib and ponatinib, in inhibiting SARS-CoV-2 omicron-mediated cytokine release in human peripheral blood mononuclear cells.

10 Feb 2022

Biological events occurring during puberty trigger sex differences in learning and memory

New research from the University of California, Irvine reveals that sex differences in learning and memory mechanisms are triggered by biological events occurring during puberty.

10 Feb 2022

Novel immune-profiling method offers a powerful alternative to conventional flow cytometry

Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers.

9 Feb 2022

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

The recent success of Paxlovid has encouraged researchers to develop new anti-covid drugs. With this in mind, scientists from the University of Pennsylvania have been investigating a new synergistic treatment. Their research is released early as an unedited version of the manuscript to be published in the journal Nature.

9 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

Persistent Ebola virus can hide in the brain and re-emerge to cause fatal disease

In a groundbreaking study published today, scientists describe how Ebola virus, which can persist in certain areas of the body, can re-emerge to cause fatal disease - even long after treatment with monoclonal antibodies.

9 Feb 2022

Super-resolution imaging of the human coronavirus genome during infection

Using high-throughput confocal super-resolution microscopy, scientists visualize the genomic material of the human coronavirus HCoV-229E.

9 Feb 2022

How SARS-CoV-2 infection progresses throughout the respiratory system

Researchers discuss the progression of SARS-CoV-2 infection throughout the respiratory epithelium.

9 Feb 2022

Research lays the groundwork to better understand and treat Crohn's disease

A paper published this week in Immunity, a leading research journal highlighting discoveries in immunology by Cell Press, lays the groundwork to better understand and treat Crohn's disease, a type of Inflammatory Bowel Disease (IBD).

9 Feb 2022

Study examines whether viagra-like drug may be effective in treating vascular dementia

A new study, published today in Alzheimer's & Dementia, tested whether tadalafil, a drug closely related to Viagra, may be effective in treating people with vascular dementia.

9 Feb 2022

30-year-old cancer drug could get another shot, study says

A study by Virginia Commonwealth University Massey Cancer Center researchers published in today's print edition of Molecular Cancer Therapeutics shows that triplatin is effective against triple negative breast cancer, which is the most aggressive form of breast cancer and has few targeted therapies.

9 Feb 2022

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife.

9 Feb 2022

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

Mycology and immunology researchers from The University of Texas at San Antonio have been selected to receive a five-year, $6.8 million grant from the National Institutes of Health to establish a San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC) focused on developing therapeutics and vaccines against coccidioidomycosis.

8 Feb 2022

Drugs News and Research

New analysis highlights growing trends in combination cancer therapy clinical trials

KHN’s ‘What the Health?’: FDA takes center stage

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Biological events occurring during puberty trigger sex differences in learning and memory

Novel immune-profiling method offers a powerful alternative to conventional flow cytometry

Researchers identify a potent new combination of antiviral drugs to combat SARS-CoV-2

Researchers reveal new therapeutic way to block oncogenic RAS mutants

Persistent Ebola virus can hide in the brain and re-emerge to cause fatal disease

Super-resolution imaging of the human coronavirus genome during infection

How SARS-CoV-2 infection progresses throughout the respiratory system

Research lays the groundwork to better understand and treat Crohn's disease

Study examines whether viagra-like drug may be effective in treating vascular dementia

30-year-old cancer drug could get another shot, study says

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Researchers identify a bivalent histone-mark switch essential for angiogenesis

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

Discovery may aid in the development of new treatments for osteoporosis

Compounds used to fight fungal diseases in plants may be driving antimicrobial resistance

NIH grant renewal will enable Nebraska scientist to advance research on virtual immune system

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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