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CSL Behring and Seattle Children's partner to develop gene therapies for primary immunodeficiency diseases

Seattle Children's Research Institute, one of the top pediatric research institutions in the world, and global biotechnology leader CSL Behring announced a strategic alliance to develop stem cell gene therapies for primary immunodeficiency diseases.

2 Jun 2020

Acceptance from families, communities shapes the lives of Sierra Leone's former child soldiers

A study in the Journal of the American Academy of Child and Adolescent Psychiatry, published by Elsevier, reports that many of the former child soldiers of Sierra Leone have been accepted by their families and communities as they try to overcome their childhood trauma, according to a team led by Boston College School of Social Work Salem Professor in Global Practice, Theresa S. Betancourt.

2 Jun 2020

Microperimetry can help determine the efficacy of novel treatments for macular diseases

Stargardt disease is an inherited eye disease. Its onset is typically in adolescence and it is among the leading causes of blindness in this age group. Symptoms range from severe loss of sharp vision to almost complete loss of sight.

2 Jun 2020

Does interferon therapy work in COVID-19?

A new study published on the preprint site medRxiv in May 2020 reports on the efficacy of interferons in treating COVID-19. The research could help evaluate the place of such therapy in the management of this disease.

2 Jun 2020

Lancet issues correction on paper than prompted WHO to suspend Hydroxychloroquine trial

The World Health Organization (WHO) suspended the hydroxychloroquine trial amid the coronavirus pandemic. The decision comes after the study findings published in The Lancet reported issues on the drug's efficacy and safety. Now, the journal has issued a correction on the figures reported in the study.

2 Jun 2020

Study reveals how essential SARS-CoV-2 protein can be stabilized and scaled for production

A research group from the University of Texas in Austin described a high-yield production of a stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S-protein) that may accelerate the development of vaccines and diagnostic tests. This methodological 'tour de force' paper is currently available on the bioRxiv* preprint server.

1 Jun 2020

Computer modeling reveals necessary vaccine efficacy threshold to prevent SARS-CoV-2 spread

A recent US study showed that in order to prevent or largely extinguish the coronavirus disease 2019 (COVID-19) outbreak without social distancing or any other measures, any vaccine would have to have an efficacy of at least 70%. The research paper is currently available on the medRxiv* preprint server.

1 Jun 2020

New MRI technique to improve tumor diagnosis

Early diagnosis of cancer is one of the highest-priority problem for the healthcare system, because it is critical for overall treatment success and saving patients' lives. DWI may be used to detect a malignancy in various tissues and organs.

1 Jun 2020

Ruxolitinib shows promise in severe COVID-19

An anti-inflammatory drug Ruxolitinib has shown promising results in the treatment of severe coronavirus disease COVID-19. The study titled, “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial,” was published as a pre-proof for the Journal of Allergy and Clinical Immunology.

31 May 2020

How susceptible are domestic animals to SARS-CoV-2?

A recent paper by Chinese researchers, published in the leading journal Science, shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) does not replicate well in dogs, pigs, chickens, and ducks; however, ferrets and cats are easily infected, and cats may transmit the virus via an airborne route.

31 May 2020

Study: First COVID-19 cases in New York City are linked to travel-related exposures

In New York City, the first confirmed COVID-19 cases arose mostly through untracked transmission of the virus from Europe and other parts of the United States, a new molecular epidemiology study of 84 patients reports.

30 May 2020

High-throughput analysis of blood plasma could help identify biomarkers for ALS

High-throughput analysis of blood plasma could aid in identification of diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis (ALS), according to research from North Carolina State University.

29 May 2020

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Patients with advanced non-small cell lung cancer (NSCLC) and the MET exon 14 (METex14) skipping mutation had a 46.5% objective response rate to the targeted therapy drug tepotinib, as shown in a study published today in the New England Journal of Medicine and presented at the 2020 American Society of Clinical Oncology Annual Meeting ASCO20 Virtual Meeting (Abstract 9556 - Poster 322) by researchers from The University of Texas MD Anderson Cancer Center.

29 May 2020

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

29 May 2020

NIH funding supports research on first therapeutic drug to regenerate heart tissue

With funding from the National Institutes of Health, University of Arkansas researchers hope to develop the first therapeutic drug that can regenerate heart tissue.

29 May 2020

Combination therapy does not show superior efficacy in newly diagnosed myeloma

The combination of carfilzomib, lenalidomide, and dexamethasone (KRd) did not show superior efficacy in patients with newly diagnosed myeloma absent a high-risk disease prognosis, compared with the standard of care--bortezomib, lenalidomide, and dexamethasone (VRd).

29 May 2020

SwRI receives $1.9 million to identify potential treatments for COVID-19

Using Department of Defense supercomputers, Southwest Research Institute is virtually screening millions of drug compounds to search for and test possible treatment options for the novel coronavirus 2019.

29 May 2020

5-day Remdesivir dose works as well as the 10-day dose in COVID-19, study finds

With more than 5.8 million people infected with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the search is on for an effective SARS-CoV-2 vaccine or drug to treat COVID-19 disease.

28 May 2020

Nanoscope received NIH grant to advance ultrafast laser-based gene delivery to the retina

The Nanoscope team has developed Multi-Characteristic Opsins to sensitize cells toward low level of white light so that vision is improved at ambient room light.

28 May 2020

Women and minorities inadequately represented in clinical trials for novel cardiometabolic drugs

Women and minorities, particularly African Americans, continue to be inadequately represented in clinical trials for novel cardiometabolic medications, with no evidence of improvement in enrollment numbers over the past decade, according to new research published last week in the Journal of the American Heart Association, an open-access journal of the American Heart Association.

28 May 2020

Efficacy News and Research

CSL Behring and Seattle Children's partner to develop gene therapies for primary immunodeficiency diseases

Acceptance from families, communities shapes the lives of Sierra Leone's former child soldiers

Microperimetry can help determine the efficacy of novel treatments for macular diseases

Does interferon therapy work in COVID-19?

Lancet issues correction on paper than prompted WHO to suspend Hydroxychloroquine trial

Study reveals how essential SARS-CoV-2 protein can be stabilized and scaled for production

Computer modeling reveals necessary vaccine efficacy threshold to prevent SARS-CoV-2 spread

New MRI technique to improve tumor diagnosis

Ruxolitinib shows promise in severe COVID-19

How susceptible are domestic animals to SARS-CoV-2?

Study: First COVID-19 cases in New York City are linked to travel-related exposures

High-throughput analysis of blood plasma could help identify biomarkers for ALS

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

NIH funding supports research on first therapeutic drug to regenerate heart tissue

Combination therapy does not show superior efficacy in newly diagnosed myeloma

SwRI receives $1.9 million to identify potential treatments for COVID-19

5-day Remdesivir dose works as well as the 10-day dose in COVID-19, study finds

Nanoscope received NIH grant to advance ultrafast laser-based gene delivery to the retina

Women and minorities inadequately represented in clinical trials for novel cardiometabolic drugs

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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