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New research points to lncRNA's key role in helping control cellular processes

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome's protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as nothing more than 'junk.'

27 Dec 2016

Genomic sequencing reveals new insights into major shigellosis outbreaks in California

In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in California in 2014 and 2015.

23 Dec 2016

Linking human genome sequences to EHR information could influence clinical medicine, says expert

The value of intersecting the sequencing of individuals' exomes or full genomes to find rare genetic variants -- on a large scale -- with their detailed electronic health record information has "myriad benefits, including the illumination of basic human biology, the early identification of preventable and treatable illnesses, and the identification and validation of new therapeutic targets," wrote Daniel J. Rader, MD, chair of the Department of Genetics, in the Perelman School of Medicine at the University of Pennsylvania, in Science this week, with Scott M. Damrauer, MD, an assistant professor of Surgery at Penn and the Veterans Affairs Medical Center in Philadelphia.

23 Dec 2016

UC researchers uncover obesity-related protein's role in leukemia development

Cancer researchers at the University of Cincinnati College of Medicine have found an obesity-associated protein's role in leukemia development and drug response which could lead to more effective therapies for the illness.

22 Dec 2016

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

An international team of scientists has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria -- the energy-producing factory of the cell -- and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans.

22 Dec 2016

Scientists identify gene variants causing unrecognized developmental disorder

An international team of scientists has identified variants of the gene EBF3 causing a developmental disorder with features in common with autism.

22 Dec 2016

New computational tool can predict personal cancer driver genes to optimize treatment

Columbia University Medical Center researchers have created a computational tool that can rapidly predict which genes are implicated in an individual's cancer and recommend treatments.

22 Dec 2016

High BMI leads to epigenetic changes, study shows

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA.

22 Dec 2016

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Scientists from the Florida campus of The Scripps Research Institute have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.

22 Dec 2016

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers at the Icahn School of Medicine at Mount Sinai are working on the basic science that lays the groundwork to finding a way to treat and prevent the Zika virus, a global health risk.

22 Dec 2016

Researchers find accumulation of tumor suppressor in liver after food withdrawal

Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité - Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal.

21 Dec 2016

Fly study shows RNA pathway plays major role in normal health and longevity

Humans and other animals carry rogue sequences of DNA in their genomes called transposable elements. To prevent passing TEs to their offspring, they employ the piRNA pathway in their reproductive organs to block the elements from being active in their sperm and eggs.

21 Dec 2016

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Cambridge Innovation Capital plc, a Cambridge-based investor in technology and healthcare companies, and IP Group plc, the developer of intellectual property-based businesses, announce the creation of Microbiotica Ltd, a newly formed spin-out company from the UK’s Wellcome Trust Sanger Institute based at the Wellcome Genome Campus in Hinxton, Cambridge.

21 Dec 2016

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Professor Frédéric Veyrier's most recent research, in collaboration with the team of Professor Hilde De Reuse at the Institut Pasteur, has shed light on key genes essential to the pathogenesis of Helicobacter pylori bacterium, which causes gastric infections.

21 Dec 2016

Genome News and Research

New research points to lncRNA's key role in helping control cellular processes

Genomic sequencing reveals new insights into major shigellosis outbreaks in California

Linking human genome sequences to EHR information could influence clinical medicine, says expert

UC researchers uncover obesity-related protein's role in leukemia development

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

Scientists identify gene variants causing unrecognized developmental disorder

New computational tool can predict personal cancer driver genes to optimize treatment

High BMI leads to epigenetic changes, study shows

TSRI scientists identify microbial natural products as abundant sources of potent anticancer drugs

Mount Sinai researchers laying groundwork to find effective treatment for Zika virus

Researchers find accumulation of tumor suppressor in liver after food withdrawal

Fly study shows RNA pathway plays major role in normal health and longevity

Wellcome Trust Sanger Institute establishes spin-out company, Microbiotica

Research sheds light on key genes essential to pathogenesis of Helicobacter pylori

Study identifies four previously unknown genetic risk locations for primary sclerosing cholangitis

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Researchers use DNA markers to differentiate harmless species from deadly bacteria

Mayo Clinic scientists show how hungry liver cells find energy

Scientists identify novel protein pathway across cancer types that fuels tumor progression

People at increased risk of schizophrenia more likely to use cannabis, research finds

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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