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Research findings change misconception on white blood cell trafficking to spleen

Contrary to prior belief, the white blood cells enter the spleen primarily via vessels in the red pulp. The research results change thoroughly our perception of the spleen producing antibodies vital for the human body.

3 Apr 2019

Single dose long lasting opioid antidote on the horizon

Recent reports have shown a 1,000 percent rise in opioid abuse (especially synthetic drug Fentanyl) in the United States over the past one decade. In 2017 for example there have been 47,000 deaths attributed to opioid overdose says the US Centre for Disease Control and Prevention (CDC).

31 Mar 2019

Scientists develop new accurate computational method to enhance drug target stability

Scientists from the Moscow Institute of Physics and Technology, the Skolkovo Institute of Science and Technology, and the University of Southern California have developed a new computational method for the design of thermally stable G protein-coupled receptors that are of great help in creating new drugs.

30 Mar 2019

Binding affinities of PFASs to Baikal seal PPARα revealed using in vitro and in silico approaches

A team of researchers at Ehime University revealed the binding affinities of perfluoroalkyl substances (PFASs) to Baikal seal peroxisome proliferator-activated receptor α (PPARα) using in vitro and in silico approaches.

30 Mar 2019

Research demonstrates clinical utility of ddPCR-powered liquid biopsy at 2019 AACR Annual Meeting

New research demonstrating the clinical utility of Bio-Rad's Droplet Digital PCR powered liquid biopsy will be presented this week during the 2019 American Association for Cancer Research Annual Meeting in Atlanta, March 29-April 3.

30 Mar 2019

Cellular mechanism that connects smoking during pregnancy and baby’s obesity risk identified

Using foreskin tissue from newborn circumcisions, a group of researchers have identified a potential cellular mechanism that connects a mother's smoking while pregnant with an increased risk of offspring obesity later in life.

30 Mar 2019

New targetable vulnerability in breast cancer cells discovered

Researchers at the University of Helsinki and Karolinska Institutet have discovered new molecular mechanisms of breast cancer cell signaling that contribute to aggressive behavior of cancer cells.

29 Mar 2019

Researchers discover how mosquitoes smell acidic volatiles in human sweat

Female mosquitoes are known to rely on an array of sensory information to find people to bite, picking up on carbon dioxide, body odor, heat, moisture, and visual cues.

29 Mar 2019

Research uncovers crucial receptor involved in response to fast-acting antidepressants

Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments.

29 Mar 2019

Nanovaccine boosts immunity in mice with gut microbiome-mediated metabolic syndrome

A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria - a population that shows resistance to traditional flu and polio vaccines.

29 Mar 2019

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule is safe and nontoxic in mice and can significantly delay tumor formation and growth.

28 Mar 2019

Researchers describe mathematical model as key to developing effective drugs for brain disorders

A collaboration between researchers from the UAB Institute of Neurosciences and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors.

28 Mar 2019

Heating tumors during CAR T-cell therapy can enhance treatment's success, study suggests

A preclinical study led by scientists at the UCLA Jonsson Comprehensive Cancer suggests that heating solid tumors during CAR T-cell therapy can enhance the treatment's success.

28 Mar 2019

Marijuana use during pregnancy may increase psychosis risk in offspring

Pregnant women who use cannabis may slightly increase the risk their unborn child will develop psychosis later in life, suggests new research from Washington University in St. Louis.

28 Mar 2019

New medication increases muscle and bone mass in mice

It is common knowledge that as people grow older they lose a large part of their muscle mass - and neither are their bones what they once were. Researchers from Aarhus University, Denmark, working together with researchers at Erasmus Medical Center in Rotterdam have now studied a new group of medication which could prove beneficial for the elderly and the chronically ill who suffer a loss of bone- and muscle mass.

28 Mar 2019

Radiolabeled protein lights up tumor to reveal where cancer drugs are working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected.

28 Mar 2019

Synthetic alcohol substitute could make hangovers a thing of the past

Professor David Nutt is aiming to make hangovers a thing of the past by introducing a synthetic alcohol alternative named "alcosynth".

27 Mar 2019

Study explores how a hallucinogenic drug impacts the brains of mice

While there is increasing interest in using hallucinogenic drugs to treat conditions like depression and post-traumatic stress disorder, scientists are just beginning to understand what these drugs actually do in the brain—and how they cause hallucinations.

27 Mar 2019

Researchers unravel biomechanics of Ebola virus-host cell adhesion

It was recently reported that the number of Ebola cases in the Democratic Republic of Congo has surpassed 1,000, making it the second-worst outbreak in history after the 2014 outbreak in West Africa in which 29,000 people were infected and more than 11,000 died.

27 Mar 2019

Exposure to dim light at night may contribute to spread of breast cancer to bones

Exposure to dim light at night, which is common in today's lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study.

25 Mar 2019

Receptor News and Research

Research findings change misconception on white blood cell trafficking to spleen

Single dose long lasting opioid antidote on the horizon

Scientists develop new accurate computational method to enhance drug target stability

Binding affinities of PFASs to Baikal seal PPARα revealed using in vitro and in silico approaches

Research demonstrates clinical utility of ddPCR-powered liquid biopsy at 2019 AACR Annual Meeting

Cellular mechanism that connects smoking during pregnancy and baby’s obesity risk identified

New targetable vulnerability in breast cancer cells discovered

Researchers discover how mosquitoes smell acidic volatiles in human sweat

Research uncovers crucial receptor involved in response to fast-acting antidepressants

Nanovaccine boosts immunity in mice with gut microbiome-mediated metabolic syndrome

Tumor biomarker EpCAM shown to be promising target for cancer immunotherapy

Researchers describe mathematical model as key to developing effective drugs for brain disorders

Heating tumors during CAR T-cell therapy can enhance treatment's success, study suggests

Marijuana use during pregnancy may increase psychosis risk in offspring

New medication increases muscle and bone mass in mice

Radiolabeled protein lights up tumor to reveal where cancer drugs are working

Synthetic alcohol substitute could make hangovers a thing of the past

Study explores how a hallucinogenic drug impacts the brains of mice

Researchers unravel biomechanics of Ebola virus-host cell adhesion

Exposure to dim light at night may contribute to spread of breast cancer to bones

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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