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Researchers discover potential new therapy for vascular disorder

Researchers from the Centenary Institute have discovered a potential new therapy for cerebral cavernous malformations, a devastating disease that often affects young people and can result in stroke and seizures.

26 Jun 2020

Study shows why ApoE4 increases risk of Alzheimer's disease

Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids - which are building blocks of the membranes surrounding the neurons.

26 Jun 2020

Irritable bowel disease heightens the risk of dementia

Scientists have long explored the link between the gut and the brain. Now, a new study shows that older adults with chronic inflammation of the digestive tract may develop dementia more than seven years earlier than those who do not have the condition.

26 Jun 2020

Chilblains and COVID-19

The current COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is primarily a respiratory infection, though the majority of cases are asymptomatic or mild disease. However, other manifestations are also being reported, such as gastrointestinal features, neurological signs, and skin symptoms. A new study published online in the journal JAMA Dermatology in June 2020 examines the possibility that chilblains could be a manifestation of COVID-19.

26 Jun 2020

Genes associated with SARS-CoV-2 human lung cell infection

Now, a new study published on the preprint server bioRxiv in June 2020 attempts to make sense of this data to identify viral genes that are explicitly expressed in the cells infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This could help reveal new therapeutic targets.

26 Jun 2020

Dysregulated inflammation in severe COVID-19

The continuing COVID-19 pandemic has so far caused 9.58 million cases and more than 488,000 deaths within just six months. The spectrum of disease is broad, from completely asymptomatic cases to critical illness ending in death. Now, a new paper by researchers from Yale University and published on the preprint server medRxiv* in June 2020 identifies an imbalance in immunological response that is linked to poor outcomes and early biomarkers that may help predict the course of the disease.

25 Jun 2020

New study explores post-COVID-19 inflammatory condition in children

In recent weeks, a multisystem hyperinflammatory condition has emerged in children in association with prior exposure or infection to SARS-CoV-2.

25 Jun 2020

Research team profiles the body's immune response to COVID-19

A team from Lawson Health Research Institute and Western University are the first in the world to profile the body's immune response to COVID-19.

25 Jun 2020

Common food additive alters gut microbiota in mice

A common food additive, recently banned in France but allowed in the U.S. and many other countries, was found to significantly alter gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver, according to research led by a University of Massachusetts Amherst food scientist.

25 Jun 2020

Protein profile in serum reflects COVID-19 severity

The wide range of manifestations of COVID-19 has continued to baffle investigators. Now, a new study published on the preprint server medRxiv in June 2020 shows that blood proteins in COVID-19 patients change over time, and these can possibly predict or reflect the severity of disease. More, they may present targets for treatment.

25 Jun 2020

Immune response variations across the COVID-19 spectrum

A new study published on the preprint server medRxiv in June 2020 describes differences in the adaptive and innate immune response in mild, moderate, and severe COVID-19. This may mean that permanent immune responses occur only in patients who recover from severe COVID-19.

25 Jun 2020

Platelets may be contributing to COVID-19

The current pandemic of COVID-19 is characterized mainly by severe acute respiratory distress of the lungs, but other organ dysfunctions are also being observed, including the heart and blood vessels. Now, a new paper published on the preprint server medRxiv* in June 2020 describes the abnormal activation of platelets in this disease and the link between this phenomenon and poor outcomes for COVID-19 patients.

24 Jun 2020

Increase in sedentary behavior can contribute to cardiovascular health deterioration

The adverse side effects of the social isolation measures implemented to combat COVID-19 include an increase in sedentary behavior and physical inactivity, which can contribute to a deterioration in cardiovascular health even in the short term. Older people and people with chronic diseases tend to be most affected.

24 Jun 2020

Short-term exposure to low level air pollution can affect gene expression

New data from a landmark study by Monash University researchers raises concerns that even short-term exposure to low level air pollution can affect gene expression, leaving us at risk of diseases such as cancer, cardiovascular and respiratory diseases.

24 Jun 2020

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

The dynamics of angiotensin-converting enzyme 2 (ACE2) expression in the kidney could have implications for the infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), say researchers.

24 Jun 2020

Statin therapy linked to lower death rate in hospitalized patients with COVID-19

The use of cholesterol-lowering drugs called statins is associated with a lower death rate and a lower incidence of mechanical ventilation in patients hospitalized with Coronavirus disease 2019 (COVID-19), researchers report June 24 in Cell Metabolism.

24 Jun 2020

Drinking unprocessed cow's milk prevents allergies, shows study

Numerous studies have shown that growing up on a farm and drinking natural, unprocessed cow's milk in early childhood protects against the development of immunoglobulins E (IgE), which are responsible for allergy symptoms.

24 Jun 2020

Study explores ways to prevent the accumulation of visceral fat among the elderly

In a new publication from Cardiovascular Innovations and Applications, Israel Oluwasegun Ayenigbara from University of Ibadan, Ibadan, Nigeria considers accumulation of visceral fat and preventive measures among the elderly.

24 Jun 2020

Mediterranean diet can protect against cognitive decline, shows study

A new study, investigating factors associated with verbal fluency among a large sample of anglophone Canadians aged 45-85, found that individuals who consumed more vegetables and fruits and more nuts and pulses (such as lentils and beans) scored higher on tests of verbal fluency.

24 Jun 2020

Bioactive factors-imprinted scaffold vehicles for boosting bone repair

Announcing a new article publication for BIO Integration journal. In this review article the authors Peng-Peng Xue, Jian-dong Yuan, Qing Yao, Ying-Zheng Zhao and He-Lin Xu, from Wenzhou Medical University, Wenzhou City, China consider bioactive factors-imprinted scaffold vehicles for promoting bone healing.

23 Jun 2020