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JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

Implementing lifestyle medicine as a high-value care solution can lead to better outcomes

The American College of Lifestyle Medicine (ACLM) has published a position paper calling for the implementation of lifestyle medicine as a high-value care solution that delivers on the Quintuple Aim-better health outcomes, higher patient and clinician satisfaction, greater health equity, and lower costs.

25 Nov 2025

AI-driven system cuts fax processing time and speeds new patient onboarding in health care

An emerging artificial intelligence-powered system developed at Penn Medicine has tripled the speed of fax processing and cut a full week off the new patient intake process-freeing up thousands of staff hours.

22 Nov 2025

Novel vaccine strategy could solve the challenge of implanted device infections

Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but significant risk that these devices get infected with bacterial pathogens.

4 Nov 2025

Johns Hopkins study reveals enzyme that shields neurons from oxidative stress

New research from Johns Hopkins Medicine shows that the enzyme biliverdin reductase A (BVRA) plays a direct protective role against oxidative stress in neurons, independent of its role producing the yellow pigment bilirubin.

3 Nov 2025

19 NCAA women's college basketball coaches join hands to support women’s heart health

Both on the court and off, cardiovascular disease is the leading killer of women in the United States, taking the lives of more than 440,000 women each year, according to the American Heart Association, a relentless force changing the future of health for everyone everywhere.

30 Oct 2025

New BRIGHT Center aims to build resilience after trauma

The Medical University of South Carolina has been awarded more than $11 million by the National Institute of General Medical Sciences over five years to establish a Center of Biomedical Research Excellence (COBRE) to build resilience after trauma, which will be known as the South Carolina Building Resilience through Innovative Interventions to promote Growth and Health after Trauma COBRE, or the BRIGHT Center.

24 Oct 2025

New antibody drug conjugates can transform early HER2-positive breast cancer treatment

In a landmark moment at the ESMO Congress 2025, pivotal studies have unveiled compelling evidence that a new class of anti-cancer agents-antibody-drug conjugates (ADCs)-can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer.

18 Oct 2025

Improving logical reasoning in large language models for medical use

Large language models (LLMs) can store and recall vast quantities of medical information, but their ability to process this information in rational ways remains variable.

17 Oct 2025

Study provides a roadmap for how health systems can improve lung cancer screening rates

Lung cancer screening might be the best-kept secret in health care today. Only about 16 percent of those who are eligible in the U.S. get screened for lung cancer, but a study coming out in NEJM Catalyst on Wednesday provides a roadmap for how health systems can improve those numbers.

15 Oct 2025

Researchers design intrinsically disordered proteins with tailored properties

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using computers to accurately predict the 3D structure of any given amino acid sequence.

7 Oct 2025

Fresh donor milk linked to reduced gastrointestinal complicatoins in premature infants

A study from the Medical University of South Carolina, published in the Journal of Parenteral and Enteral Nutrition, reveals that shorter storage durations of donor human milk are linked to reduced gastrointestinal complicatoins in premature infants, including necrotizing enterocolitis.

24 Sep 2025

Study sheds light on how inadequate sleep in teens can contribute to cycles of violence

Mass General Brigham study also finds link to violent behaviors such as carrying a weapon, highlighting the vicious cycle between lack of sleep and violence.

22 Sep 2025

Adults with both Down Syndrome and congenital heart defects show remarkable resilience

Adults with both Down Syndrome and congenital heart defects, also known as congenital heart disease (CHD), are showing remarkable resilience despite facing significant medical challenges, according to a new MUSC study in Pediatric Cardiology.

19 Sep 2025

AI tool analyzes brain activity to support and prioritize autism assessments

Scientists have developed and tested a deep-learning model that could support clinicians by providing accurate results and clear, explainable insights – including a model-estimated probability score for autism.

19 Sep 2025

GLP-1 drugs may offer cost-effective treatment for people with knee osteoarthritis and obesity

A new study led by investigators at Mass General Brigham finds that adding novel weight loss GLP-1 drugs semaglutide and tirzepatide to usual care represents a cost-effective treatment strategy for people with knee osteoarthritis and obesity, with tirzepatide providing greater health benefits at lower cost compared to semaglutide.

16 Sep 2025

Targeting complement with an inhibitor may prevent preterm birth and protect the baby’s brain

A research team at the Medical University of South Carolina reports in Cells that the complement system, part of the body's natural immune defenses, is a key driver of inflammatory responses that contribute to fetal brain inflammation and preterm birth, the latter of which is the leading cause of complications and death in newborns.

4 Sep 2025