Liquid Chromatography News and Research

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Mediterranean diet lowers dementia risk by altering key metabolites

Researchers linked genetics, plasma metabolites, and Mediterranean diet adherence to dementia risk in two large US cohorts, showing APOE4 homozygotes had distinct metabolic pathways. Diet-related metabolites mediated protection, highlighting precision-prevention opportunities.

26 Aug 2025

Synthetic Psychedelics: A Growing Public Health Concern

In this interview, Jonathan Ferguson discusses how knowledge of an emerging public health concern identified at Pittcon 2024 has evolved a year on.

From Pittcon 26 Aug 2025

Fish oil supplementation can reduce risk of developing type 2 diabetes in prediabetic individuals

Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality.

20 Aug 2025

Study shows promising anti-diabetic potential of coffee's functional components

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

18 Aug 2025

Flavonols found in foods can block drug resistance protein and boost medication absorption

Researchers identified specific flavonols that potently inhibit breast cancer resistance protein (BCRP), a key driver of drug resistance and poor oral drug absorption. The study found that these flavonols can reverse chemotherapy resistance in vitro and boost drug exposure in animal models, though clinical translation remains uncertain.

6 Aug 2025

New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025

Powerful bioactives found in overlooked Amazonian fruits

Lesser-known Amazonian fruits exhibit strong antioxidant and antimicrobial properties, highlighting their role in public health and biotechnology research.

31 Jul 2025

Prenatal phthalates lower boys' verbal IQ but lift girls' performance IQ, Canadian study reveals

Prenatal exposure to certain phthalates, especially DiDP, was linked to slightly lower IQ scores in preschoolers, with boys appearing more vulnerable. Other phthalates, like MMP and MBzP, showed small positive associations, but mixture effects were not significant.

29 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025

The Proteoform Puzzle: Unlocking the Next Frontier

In the interview, Lloyd M. Smith discusses proteoforms, an area of research worthy of the next Human Genome Project.

From Pittcon 10 Jul 2025

Warming temperatures and CO2 levels threaten food quality

New preliminary research suggests that a combination of higher atmospheric CO2 and hotter temperatures contribute to a reduction in nutritional quality in food crops, with serious implications for human health and wellbeing.

9 Jul 2025

Early exposure to plastics raises young children’s asthma risk

A large international study found that early-life exposure to phthalates, common chemicals in plastics, is modestly associated with increased risks of asthma, wheeze, and rhinitis in children under five. No consistent associations were found for bisphenols, and effects were generally small.

6 Jul 2025

COVID-19 triggers metabolic signatures in kids that mirror adult heart risk

Children with acute COVID-19 and MIS-C show significant disruptions in lipid metabolism, including patterns resembling adult severe COVID-19. These findings highlight potential long-term cardiovascular risks in pediatric SARS-CoV-2 cases and underscore the need for follow-up care.

16 Jun 2025

Skin biomarkers may offer noninvasive diagnosis for pediatric eosinophilic esophagitis

A groundbreaking study led by National Jewish Health researchers suggests that the skin may serve as a potential biomarker for a chronic allergic disease of the esophagus called eosinophilic esophagitis (EoE) in children.

6 Jun 2025

Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicity

A recent study published in Engineering has shed light on the relationship between gut microbiota, isoflavones, and geniposide hepatotoxicity.

26 May 2025

Black tea kombucha reduces harmful gut microbes linked to obesity

Regular consumption of black tea kombucha for eight weeks beneficially shifted gut microbiota composition in both normal-weight and obese adults.

14 May 2025

How urine caffeine levels may help detect diabetic eye damage early

Researchers found that higher urinary levels of caffeine and specific metabolites, especially in men, were significantly associated with diabetic retinopathy risk. The cross-sectional study used NHANES 2009–2014 data and highlights potential biomarkers for early detection in diabetic populations.

7 May 2025