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Cells use liquid droplets to regulate signaling pathways, study finds

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that can carry out the necessary response.

22 Apr 2024

Young mouse plasma found to reverse aging in older mice

Researchers demonstrate that small extracellular vesicles (sEVs) from young mice plasma can reverse aging effects in older mice by enhancing mitochondrial function and energy metabolism.

22 Apr 2024

AI models fall short in medical coding accuracy

State-of-the-art artificial intelligence systems known as large language models (LLMs) are poor medical coders, according to researchers at the Icahn School of Medicine at Mount Sinai.

22 Apr 2024

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity

Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy.

22 Apr 2024

Insightful review explores alcohol-related liver cancer pathogenesis

While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC remain unclear.

22 Apr 2024

Top pharmaceutical company evaluates Optimer for precision liver medicine

Optimer delivery vehicle has been shipped to a pharma partner for external evaluation.

From Aptamer Group 22 Apr 2024

Korean fermented food Doenjang shows promise in alleviating menopausal symptoms

Study compares the effects of traditional versus commercial Korean Doenjang on menopausal symptoms, finding that traditional variants with high beneficial microorganisms are more effective in reducing these symptoms and improving cardiovascular and gut health.

21 Apr 2024

Study links air pollution to increased colorectal cancer risk through DNA changes

Researchers reveal how air pollution increases colorectal cancer (CRC) risk through epigenetic changes, using a large-scale study and Mendelian randomization to demonstrate ambient pollution’s impact on CRC mortality and incidence in China.

21 Apr 2024

Researchers receive NIH grant to help develop gene therapy for HIV

Researchers at Washington University School of Medicine in St. Louis have received a $6.2 million grant from the National Institutes of Health (NIH) to develop a gene therapy that would modify the immune system's B cells to spur them to produce broadly neutralizing antibodies against HIV.

18 Apr 2024

WOO Network trials investigate innovative treatments for liver, head and neck cancers

A new round of clinical trials supported by the Ontario Institute for Cancer Research (OICR) will harness a unique opportunity to test some of the newest treatment strategies for a range of different cancers.

18 Apr 2024

The path to a better tuberculosis vaccine runs through Montana

A team of Montana researchers is playing a key role in the development of a more effective vaccine against tuberculosis, an infectious disease that has killed more people than any other.

18 Apr 2024

Exploring the versatile roles of tissue macrophages beyond immune defense

The role of resident tissue macrophages (RTMs) in homeostasis and disease.

17 Apr 2024

Vitamin D deficiency persists despite easy access, review suggests need for tailored supplements

Researchers in a study published in the journal Nutrients delve into the pervasive issue of vitamin D deficiency and its link to various health conditions, advocating for precision nutrition and personalized supplementation to enhance vitamin D intake and effectiveness.

17 Apr 2024

Study reveals novel approach to promote efficient uptake of ASOs into cancer cells

Antisense oligonucleotides (ASOs) are next-generation drugs that can treat disease by blocking the transfer of harmful messages from our genes.

16 Apr 2024

Pitt researchers uncover mechanisms behind uveal melanoma resistance

New research from the University of Pittsburgh explains why metastatic uveal melanoma is resistant to conventional immunotherapies and how adoptive therapy, which involves growing a patient's T cells outside the body before reinfusing them, can successfully treat this rare and aggressive cancer.

16 Apr 2024

Study reveals microplastics' significant impact on digestive pathways

It's happening every day. From our water, our food and even the air we breathe, tiny plastic particles are finding their way into many parts of our body.

15 Apr 2024

Canada unlikely to eliminate Hepatitis C by 2030, study finds

Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus (HCV) by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

15 Apr 2024