Medicinal Chemistry News and Research

RSS

New compound shows promise in treating hard-to-treat inflammatory conditions

Irritable bowel syndrome, chronic itching, asthma and migraine are in many cases hard-to-treat conditions.

24 Apr 2025

San Antonio scientists use machine learning to identify potential treatments for deadly viruses

A team of San Antonio-based biomedical researchers trained a machine learning algorithm to identify more than two dozen viable treatments for diseases caused by zoonotic pathogens that can jump from animal hosts to infect humans.

23 Apr 2025

Major breakthrough could turn IV drugs into oral treatments for brain cancer and Alzheimer's

A research team led by scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) made a major breakthrough with the potential to turn IV drugs into oral treatments for diseases like brain cancer and Alzheimer's disease.

21 Apr 2025

New discovery enhances cell entry for complex cancer drugs

A new discovery could pave the way for more effective cancer treatment by helping certain drugs work better inside the body.

17 Apr 2025

Rutgers researchers develop promising new oral antiviral for COVID-19

Rutgers Health researchers have developed an oral antiviral drug candidate for COVID-19 that could overcome major limitations of Paxlovid, currently the most prescribed oral treatment.

3 Apr 2025

ELRIG announces Prof Rory Johnson and Dr Shalini Andersson as keynote speakers at Therapeutic Oligonucleotides 2025

ELRIG, a not-for-profit, volunteer-led organization for the drug discovery community, today announced the keynote speakers for Therapeutic Oligonucleotides 2025 taking place at the AstraZeneca R&D site in Gothenburg, Sweden from 14-15 May. Prof Rory Johnson, Associate Professor, University College Dublin, and Dr Shalini Andersson, Vice President Nucleic Acid Therapeutics, AstraZeneca will lead this year's event focused on 'drugging the undruggable'.

25 Mar 2025

New light-driven process could accelerate the discovery of new drugs

Researchers at Indiana University and Wuhan University in China have unveiled a groundbreaking chemical process that could streamline the development of pharmaceutical compounds, chemical building blocks that influence how drugs interact with the body.

22 Mar 2025

Researchers develop new compound to treat alopecia areata

A research group, led by Dr. Pavel Majer from IOCB Prague, in collaboration with the laboratories of Barbara Slusher and Louis Garza at Johns Hopkins University, have developed a compound that could potentially treat the autoimmune disorder alopecia areata, which causes hair loss leading to the formation of bald patches.

13 Mar 2025

Study reveals TCM-Based strategies for ferroptosis modulation

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis, offering novel therapeutic approaches for various conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and organ injuries.

11 Mar 2025

EU project aims to combat dangerous viruses with molecular interventions

Targeted molecular interventions in the replication cycle and the immune recognition of viruses are intended to prevent viral entry into cells and virus replication.

27 Feb 2025

Innovative photodynamic therapy targets melanoma with light-activated dyes

Melanoma is one of the most aggressive skin cancers, with over 300,000 new cases reported worldwide each year. In Europe, the number of diagnoses has been rising rapidly.

17 Feb 2025

Innovative approach to synthesizing functional molecules with triple click chemistry

Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature, demanding the development of a new approach that can overcome these disadvantages.

11 Feb 2025

Advances in the design and synthesis of isosteviol derivatives

Announcing a new publication for Acta Materia Medica journal. Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, and anticardiovascular disease roles.

11 Feb 2025

Insilico Medicine develops highly selective FGFR2/3 dual inhibitor for cancer treatment

Fibroblast growth factor receptors (FGFRs) are critical drivers of oncogenesis in various solid tumors, including urothelial carcinoma, hepatocellular carcinoma, ovarian cancer and lung adenocarcinoma.

7 Feb 2025

EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs

Pandemics threaten both human health and the global economy. Vaccines are an essential part of the fight against pandemics, but they are only available months after the outbreak

23 Jan 2025

New modular strategy reduces piperidine synthesis steps for pharmaceuticals

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to create complex, three-dimensional molecules. This innovation could help accelerate drug discovery and enhance the efficiency of medicinal chemistry.

20 Dec 2024

Photocatalysed flow method accelerates synthesis of potent MC4R antagonist

Asynt report that the Cresswell Group, led by Dr Alexander J. Cresswell at the University of Bath (UK), have demonstrated the synthesis of novel spirocyclic tetrahydonaphthyridines (THNs) expanding the chemical space of these important scaffolds for drug discovery.

From Asynt 17 Dec 2024

Researchers use innovative approach to uncover hidden bioactive compounds in bacteria

In contrast to humans, bacteria have the remarkable ability to exchange genetic material with each other.

14 Dec 2024

New gold-based drug proves to be more potent than standard chemotherapy

A new gold-based drug can slow tumour growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a study by Australian and Indian researchers.

27 Nov 2024

Enterprise Therapeutics publishes on medicinal chemistry of ETD001, a novel inhaled ENaC blocker for treatment of cystic fibrosis

Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of people with respiratory diseases, today announced the publication of a peer reviewed study in The European Journal of Medicinal Chemistry.

From Enterprise Therapeutics Ltd 25 Nov 2024