Model Organisms News and Research

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New insights into role of cholinergic centro-cingulate network in Parkinson's disease and normal aging

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Cholinergic centro-cingulate network in Parkinson disease and normal aging."

1 Nov 2023

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature."

31 Oct 2023

Arterial DNA damage contributes to vascular aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, "Reduction of double-strand DNA break repair exacerbates vascular aging."

18 Oct 2023

Study highlights role of circadian clock component BMAL1 on molecular phenotype of senescent cells

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, "BMAL1 modulates senescence programming via AP-1."

16 Oct 2023

Study reveals molecular mechanism behind new DOT1L-related disorder

A study from the laboratory of Dr. Hugo J. Bellen, a distinguished service professor at Baylor College of Medicine and a principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, has discovered that gain-of-function variants in the DOT1L gene cause a new disorder.

13 Oct 2023

Study identifies pathways explaining racial/ethnic and socio-economic disparities in dementia

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, "Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study."

11 Oct 2023

New zebrafish xenograft platform could help screen for glioblastoma treatments

Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study by the Gerhardt and De Smet labs published in EMBO Molecular Medicine.

4 Oct 2023

New AI model predicts therapeutic targets for age-related diseases

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, "Biomedical generative pre-trained based transformer language model for age-related disease target discovery."

4 Oct 2023

Challenges and opportunities for better lung cancer care for the elderly

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 17, entitled, "Promising trends in lung cancer care, but are we overlooking the majority?"

28 Sep 2023

Living donor liver transplantation improves waitlist outcomes in high-risk cirrhosis patients

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 17, entitled, "Availability of living donor optimizes timing of liver transplant in high-risk waitlisted cirrhosis patients."

26 Sep 2023

Study discovers a new endocytic pathway in budding yeast

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients.

25 Sep 2023

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

Researchers develop new protocol to study white matter injury in Alzheimer's disease

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Microvascular contributions to white matter injury in Alzheimer's disease."

13 Sep 2023

Aging reorganizes pancreas circadian transcriptome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Reorganization of pancreas circadian transcriptome with aging."

5 Sep 2023

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

A comprehensive review in the journal Cell outlines a unified framework for classifying and validating aging biomarkers, aiming to streamline their integration into clinical research and practice. The study categorizes biomarkers into types like molecular, functional, and clinical, and sets criteria for their feasibility, validity, and applicability, all with the goal of better understanding and intervening in the aging process.

5 Sep 2023

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging."

31 Aug 2023

Model Organisms News and Research

New insights into role of cholinergic centro-cingulate network in Parkinson's disease and normal aging

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

Arterial DNA damage contributes to vascular aging

Study highlights role of circadian clock component BMAL1 on molecular phenotype of senescent cells

Study reveals molecular mechanism behind new DOT1L-related disorder

Study identifies pathways explaining racial/ethnic and socio-economic disparities in dementia

New zebrafish xenograft platform could help screen for glioblastoma treatments

New AI model predicts therapeutic targets for age-related diseases

Challenges and opportunities for better lung cancer care for the elderly

Living donor liver transplantation improves waitlist outcomes in high-risk cirrhosis patients

Study discovers a new endocytic pathway in budding yeast

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers develop new protocol to study white matter injury in Alzheimer's disease

Aging reorganizes pancreas circadian transcriptome

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

Healthy aging can be achieved by optimizing diet at an early stage in life

Study opens the door to new treatments for bone regeneration and osteoporosis

Klotho levels and telomere length may be associated through a coordinated downregulation of longevity factors

NLRP3 inflammasome plays a role in podocyte aging

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