Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Elusive stem cells offer clues to treat lumbar spinal stenosis

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

7 Sep 2026

Scientists traced a hidden immune route that may worsen tau-linked brain damage

In a mouse model of tauopathy, conventional type 1 dendritic cells (cDC1s) cross-presented brain-derived antigens in deep cervical lymph nodes, priming CD8+ T cells that accumulated in the brain and promoted neurodegeneration. Disrupting cDC1s or their cross-presentation activity reduced CD8+ T-cell infiltration and protected against neuronal loss, while human primary tauopathy samples also showed increased brain CD8+ T cells, although cDC1 involvement in humans remains unconfirmed.

6 Sep 2026

Mitochondrial stress triggers long-term protection against heart damage

Mitochondria are popularly known as the "powerhouse of the cell," but these cellular structures do so much more-including acting as signaling hubs.

4 Sep 2026

What your gut microbes may have to do with how your brain ages

This review examines how diet-driven changes in the gut microbiota and microbial metabolites may influence cognitive aging through immune, metabolic, neural, endocrine, and barrier-related pathways. It highlights SCFAs, tryptophan-derived metabolites, and bile acids as key signaling mediators while emphasizing that much of the mechanistic evidence remains preclinical and human evidence is largely associative.

3 Sep 2026

Cancer-fighting T cells need small amounts of ROS to attack tumors, study finds

New research reveals a promising new target for treating cancer by harnessing a type of molecule previously thought to do more harm than good.

3 Sep 2026

Cancer drug eliminates HIV-infected cells in animal model study

Emory University researchers have provided the first proof-of-concept in a nonhuman primate model for eliminating HIV-infected cells with venetoclax, a clinically approved medication for cancer.

3 Sep 2026

Two scientists win Horwitz Prize for Rett syndrome breakthrough

Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

2 Sep 2026

Host-targeting drugs offer new way to fight flu resistance

A drug that targets the host rather than the virus could get around the problem of anti-viral resistance. Every year, hundreds of thousands of people die of seasonal influenza, caused by infection with influenza A and B viruses.

1 Sep 2026

Estrogen hormone combination may help relieve menopausal brain fog

Many women going through menopause report struggling with memory lapses, trouble concentrating and slower thinking, a set of symptoms often described as "brain fog."

1 Sep 2026

AI platform uncovers new molecular targets for Alzheimer's disease

Groundbreaking study published in Alzheimer's & Dementia reveals the crucial links between the NAD⁺-mitophagy axis and neurodegeneration.

1 Sep 2026

AI tools map tumor architecture to predict treatment response

Spatial transcriptomics is a powerful tool to create a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue.

31 Aug 2026

Milvexian fails to reduce cardiovascular events after acute coronary syndrome

Milvexian did not reduce major adverse cardiovascular events compared with placebo after a recent acute coronary syndrome and there was no increase in intracranial or fatal bleeding.

29 Aug 2026

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

29 Aug 2026

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice.

27 Aug 2026

New mutant rat model replicates human chronic kidney disease

Chronic kidney disease (CKD) is a major health burden affecting approximately one in ten adults globally. Even with improved treatments, many patients continue to have worsening loss of kidney function, resulting in the need for dialysis or transplantation.

27 Aug 2026

Study challenges traditional breast cancer classification methods

Breast cancer is often classified as either estrogen receptor-positive (hormone-sensitive) or not. However, a new study from Karolinska Institutet suggests that this simplified classification may overlook important biological differences between patients that could affect treatment decisions.

27 Aug 2026

Faulty myelin-making brain cells may help drive cognitive decline with age

Researchers found that greater age-related cognitive decline was associated with more dysfunctional oligodendrocytes, reduced NRF2 expression, smaller myelinated axons, and abnormally thicker myelin in human white matter. Experiments in mice showed that deleting NRF2 specifically from oligodendrocytes reproduced key white matter abnormalities and reduced cognitive improvement over time, implicating this pathway in cognitive aging.

26 Aug 2026

A major NFL brain study puts new numbers on the burden of CTE

Researchers analyzed 1,712 former NFL players who died between 2008 and 2021, including 338 brain donors, to estimate the possible prevalence of chronic traumatic encephalopathy (CTE) at death and its association with dementia. At least 24.5% of players who died from 2016 to 2021 had confirmed CTE, while stage IV CTE among brain donors was associated with a 44% higher risk of clinician-adjudicated dementia.

26 Aug 2026

New retina model reveals how CLN3-Batten disease damages vision

Researchers have developed a new way to study CLN3-Batten disease, a rare, inherited condition that causes early vision loss in children followed by progressive neurological decline.

26 Aug 2026

Molecular switch ERBB4 linked to broad range of Alzheimer's pathologies

What if amyloid plaques are not the whole story of Alzheimer's disease? New research suggests that a broad range of Alzheimer's pathologies may be orchestrated by a molecular switch called ERBB4 when it turns on in the wrong neurons.

26 Aug 2026