Proteostasis News and Research

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Each mammalian cell contains up to 20,000 proteins, all of which must be maintained and regulated. Proteostasis is a complex pathway that functions to maintain all of the proteins within and around a cell.

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

A new study, released as a preprint on the bioRxiv* server, casts some light on the pathogenesis of acute and subacute neurological complications associated with COVID-19.

19 Apr 2021

Researchers describe a new approach to treating Parkinson's disease

Parkinson's disease is the second most common, age-related, neurodegenerative disease: In Germany alone, about 300,000 people are affected and experience sometimes major limitations to their quality of life.

20 Mar 2021

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease.

11 Mar 2021

Potential new treatment approach to fatal COVID-19

Researchers from the University of Colorado Anschutz Medical Campus and Pathways Bioscience in the United States have found that activating a transcription factor involved in oxidative stress regulation, antiviral activity, and inflammation may serve as a new treatment approach to coronavirus disease 2019 (COVID-19).

18 May 2020

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body.

3 May 2020

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins.

28 Apr 2020

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

An important biological mechanism that is thought to protect brain cells from neurodegenerative diseases such as Alzheimer's and Parkinson's may also be involved in regulating sleep, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

12 Mar 2020

Researchers establish a gene expression profile associated with cachexia in cancer patients

It is estimated that as many as 80% of advanced-stage cancer patients may develop cachexia, a potentially fatal metabolic syndrome characterized by extreme weight loss and muscle wasting, but scientists do not yet fully understand why it is more frequently associated with certain kinds of tumor than others, or why not all cancer patients develop it.

3 Mar 2020

ADDF announces new awards through its Diagnostics Accelerator initiative

The Alzheimer's Drug Discovery Foundation announced six new investments totaling $6 million through its Diagnostics Accelerator initiative.

4 Dec 2019

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the U.S. -- with drugs that target the body's response to cellular stresses.

15 Nov 2019

Stony Brook-led study reveals how proteome collapse process drives cell death and aging

Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death.

16 Oct 2019

Scientists demonstrate influence of food odors on proteostasis

The smell of food induces a variety of physiological processes in our body. Thus, the production of saliva and digestive enzymes is stimulated before the actual food intake in order to prepare the gastrointestinal tract for the upcoming digestive process.

20 Feb 2019

Antibiotic could protect against age-related brain diseases

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.

28 Nov 2018

Researchers acquire new insights into DNA polymerases

Complex biological systems can be described as a network of chemical processes that take place in molecules. The scientists of the "ChemLife" research initiative at the University of Konstanz are working together in an equally active network with dynamic interconnections - both subject-specific and interdisciplinary.

19 Sep 2018

Scientists take important step to understand mechanisms that cause Huntington's disease

The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne's Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease.

27 Jul 2018

Proteostasis News and Research

Further Reading

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

Researchers describe a new approach to treating Parkinson's disease

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

Potential new treatment approach to fatal COVID-19

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

Researchers establish a gene expression profile associated with cachexia in cancer patients

ADDF announces new awards through its Diagnostics Accelerator initiative

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

Stony Brook-led study reveals how proteome collapse process drives cell death and aging

Scientists demonstrate influence of food odors on proteostasis

Antibiotic could protect against age-related brain diseases

Researchers acquire new insights into DNA polymerases

Scientists take important step to understand mechanisms that cause Huntington's disease

Researchers find link between increased proteostasis and immortality of stem cells

Research findings could help understand how Parkinson's develops on molecular level

MDI Biological Laboratory scientist sheds light on molecular mechanisms underlying aging

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Scientists identify how tumor cells exploit function of mitochondria to support cancer proliferation

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