Small Molecules News and Research

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Insilico Medicine and Qilu Pharmaceutical partner to develop AI-designed cardiometabolic drugs

Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, and Qilu Pharmaceutical Group, a major comprehensive modern pharmaceutical enterprise in China, as well as its subsidiary Shanghai Qilu Pharmaceutical Research Center, today announced a strategic partnership on innovative drug development, leveraging Insilico's proprietary Pharma.AI platform to jointly develop small molecule inhibitors, focusing on specific targets for cardiometabolic disease management.

27 Jan 2026

Novel method predicts asthma exacerbations with high degree of accuracy

Researchers at Mass General Brigham and Karolinska Institutet have identified a new method to predict asthma exacerbations with a high degree of accuracy. The study is published in Nature Communications.

19 Jan 2026

Blood metabolites reveal who will develop type 2 diabetes years before diagnosis

This large prospective study integrated blood metabolomics, genetics, and lifestyle data to identify hundreds of metabolites associated with long-term risk of type 2 diabetes in initially healthy adults. A validated 44-metabolite signature improved risk prediction beyond conventional factors, offering insights into biological pathways and opportunities for earlier, more precise prevention.

18 Jan 2026

Gut microbiota analysis offers insights into how ultra processed foods affect health

To gain more knowledge about how ultra-processed food affects us, we need new research methods, claim researchers. Now they are looking to better understand our intestinal flora.

16 Jan 2026

Polyamines reshape protein phosphorylation to guide key cellular fate decisions

Polyamines are small molecules naturally present in all cells and are critical in guiding cellular decisions, whereas an alteration in the abundance of these metabolites is invariably observed in pathological scenarios such as cancer or aging.

14 Jan 2026

DTU researchers discover gut bacteria link to reduced allergy and asthma risk

Researchers from DTU have patented an invention that uses naturally produced substances from gut bacteria of the bifidobacteria type to reduce the risk of allergies and asthma.

14 Jan 2026

New metabolomic signature predicts type 2 diabetes risk beyond traditional factors

Diabetes, a metabolic disease, is on the rise worldwide, and over 90 percent of cases are type 2 diabetes, where the body does not effectively respond to insulin.

14 Jan 2026

Resistance to rezatapopt: New TP53 mutations identified in cancer patients

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics.

12 Jan 2026

Metabolic BMI reveals hidden health risks in normal weight individuals

People of normal weight may also be at risk of diabetes and similar diseases. A study from the University of Gothenburg reveals that those with an unexpectedly high so-called metabolic BMI have up to a five times higher risk level.

12 Jan 2026

Ultrasound-responsive nanocatchers enable precise in-situ tumor antigen capture

Professor Zhaohui Tang and Associate Professor Zhilin Liu from the team of Professor Xuesi Chen at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, developed ultrasound-responsive in-situ antigen nanocatchers (S-nanocatchers), achieving precise spatiotemporal capture of tumor antigens and controllable acquisition of in-situ vaccines.

9 Jan 2026

Scientists identify a molecular switch that controls water flow in the gut

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in the U.S. each year, yet scientists have not fully understood what regulates intestinal fluid balance.

9 Jan 2026

Bowel preparation for colonoscopies may temporarily alter gut balance, preclinical study suggests

New preclinical research suggests that bowel preparation procedures for colonoscopies may temporarily alter gut balance, culminating in unappreciated effects in patients with compromised gastrointestinal health.

8 Jan 2026

Novel approach uncovers possible drugs based on specific cellular targets for treating glioblastoma

Researchers have developed a new computational approach that uncovers possible drugs for specific cellular targets for treating glioblastoma, a lethal brain tumor.

7 Jan 2026

Newly discovered molecules accelerate the removal of immune-modulating enzyme

Cells have a remarkable housekeeping system: proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery.

7 Jan 2026

Enveda’s third asset to the clinic with US FDA IND clearance: What it means for Inflammatory Bowel Disease

Enveda, a multi-asset clinical-stage biotech company pioneering the discovery and development of a new generation of small-molecule drugs derived from life’s chemistry, has announced that the US Food and Drug Administration (FDA) has cleared the Company’s Investigational New Drug (IND) application for ENV-6946.

From Hanson Wade Group - 4th Precision Medicine in Inflammatory Bowel Disease Summit 6 Jan 2026

Paternal microplastic exposure alters metabolic health in offspring

A study led by biomedical scientists at the University of California, Riverside, has shown for the first time that a father's exposure to microplastics (MPs) can trigger metabolic dysfunctions in his offspring.

23 Dec 2025

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.

21 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

Higher PFAS levels reduce blood sugar improvements after teen bariatric surgery

A new USC study shows teens with higher blood levels of per- and polyfluoroalkyl substances (PFAS) measured before bariatric surgery had smaller improvements in blood sugar over five years, including fasting glucose and hemoglobin A1c (HbA1c), which measures average blood sugar levels over the past 60-90 days.

4 Dec 2025

Kinase inhibitors can accelerate the degradation of target proteins, study reveals

Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins.

26 Nov 2025

Small Molecules News and Research

Insilico Medicine and Qilu Pharmaceutical partner to develop AI-designed cardiometabolic drugs

Novel method predicts asthma exacerbations with high degree of accuracy

Blood metabolites reveal who will develop type 2 diabetes years before diagnosis

Gut microbiota analysis offers insights into how ultra processed foods affect health

Polyamines reshape protein phosphorylation to guide key cellular fate decisions

DTU researchers discover gut bacteria link to reduced allergy and asthma risk

New metabolomic signature predicts type 2 diabetes risk beyond traditional factors

Resistance to rezatapopt: New TP53 mutations identified in cancer patients

Metabolic BMI reveals hidden health risks in normal weight individuals

Ultrasound-responsive nanocatchers enable precise in-situ tumor antigen capture

Scientists identify a molecular switch that controls water flow in the gut

Bowel preparation for colonoscopies may temporarily alter gut balance, preclinical study suggests

Novel approach uncovers possible drugs based on specific cellular targets for treating glioblastoma

Newly discovered molecules accelerate the removal of immune-modulating enzyme

Enveda’s third asset to the clinic with US FDA IND clearance: What it means for Inflammatory Bowel Disease

Paternal microplastic exposure alters metabolic health in offspring

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Higher PFAS levels reduce blood sugar improvements after teen bariatric surgery

Kinase inhibitors can accelerate the degradation of target proteins, study reveals

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