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Researchers identify ferroptosis as driver of osteocyte death in melanoma metastasis

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

23 Jan 2025

Uncertainty surrounds effects of puberty blockers and hormone therapy for gender dysphoria

Major uncertainties remain about the impact of puberty blockers and gender affirming hormone therapy on children and young people with gender related distress (gender dysphoria), making it impossible to determine conclusively whether they help or harm, find two pooled data analyses of the available evidence, published online in the Archives of Disease in Childhood.

23 Jan 2025

Understanding the long-term effects of repetitive head hits in athletes

The impact makes us cringe-the sound of two helmets making contact during a football game, a player down on the field.

23 Jan 2025

Pomalidomide shows promise in enhancing immune responses in myeloma

A new editorial was published in Oncoscience's Volume 12 on January 14, 2025, titled "Pomalidomide improved immune profiles in myeloma."

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

Maternal vitamin D deficiency may accelerate fetal aging and impact newborn health

Maternal vitamin D deficiency during pregnancy is linked to accelerated epigenetic gestational age in infants at birth, suggesting improper fetal development influenced by low vitamin D levels. The study also found associations between maternal age, birth height, and epigenetic aging, though cord blood vitamin D showed no significant impact.

22 Jan 2025

Strong heart, strong bones: How cardiovascular health influences bone density

Higher cardiovascular health (Life’s Essential 8 scores) is linked to greater bone mineral density in adults aged 20–59, with stronger associations in younger individuals, women, and those with normal BMI, suggesting heart-healthy habits may protect bone strength.

22 Jan 2025

Study reveals how gut bacteria influence immune cell training and inflammation

A study led by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid reveals how an increase in intestinal permeability allows the natural gut bacteria to cross the intestinal barrier and reach the bone marrow, where they induce epigenetic changes-modifications that alter gene activity without affecting DNA sequence-in the stem cells that give rise to immune cells.

22 Jan 2025

Researchers develop mRNA-based blood clots to treat osteoarthritis

University of Wisconsin–Madison researchers have developed a promising technique for treating osteoarthritis using therapeutic blood clots activated by messenger RNA.

22 Jan 2025

$2.5 Million Grant Awarded to Indiana University School of Medicine, Beckman Coulter Life Sciences to Expand Leukemia and Lymphoma Testing in Africa

Beckman Coulter and Indiana University receive a $2.5 million grant to expand leukemia and lymphoma testing in Western Kenya, boosting early diagnosis efforts.

From Beckman Coulter Life Sciences - Flow Cytometry 22 Jan 2025

Scientists discover critical factor in bone remodeling process

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

21 Jan 2025

New imaging protocol enhances visualization of rare bone marrow cells

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately identify rare LepR+ stromal cells.

21 Jan 2025

Researchers create an atlas of health associations for GLP-1 receptor agonists

Insights from a study on GLP-1 receptor agonists reveal benefits for cardiometabolic health, with notable risks for gastrointestinal and musculoskeletal issues.

20 Jan 2025

Antihistamines offer new hope for erythropoietic protoporphyria-related liver disease

Chlorcyclizine shows promise in reducing protoporphyrin-IX accumulation and liver damage in erythropoietic protoporphyria, targeting histamine pathways.

20 Jan 2025

DDR2 enhances BMP-dependent bone regeneration and reduces heterotopic ossification

Bone loss resulting from trauma, fractures, or disease presents a major global health challenge, often leading to long-term disability.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Researchers discover a major driver of osteosarcoma

A major driver of the bone cancer osteosarcoma has been discovered by researchers from UCL, EMBL EBI and the Royal National Orthopaedic Hospital, providing insights that could help to predict cancer severity and how patients will respond to treatment.

16 Jan 2025

Drug in breast cancer trials shows potential for treating blood cancers

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

16 Jan 2025

Antihistamine shows promise for treating rare genetic liver disease

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health.

16 Jan 2025

Global Commission proposes new framework for obesity diagnosis and treatment

A global Commission, published in The Lancet Diabetes & Endocrinology and endorsed by 75 medical organizations around the world, presents a novel, nuanced approach to diagnose obesity, based on other measures of excess body fat in addition to body mass index (BMI), and objective signs and symptoms of ill health at the individual level.

15 Jan 2025