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New level of control over stem cells will help accelerate research, lead to therapeutic applications

Researchers from Tokyo Metropolitan University have been quantifying how different batches of mesenchymal stem cells respond to the mechanical stiffness of their environments.

22 May 2021

Researchers find new clue to restore congenital hearing loss

Researchers at Oregon State University have found a key new piece of the puzzle in the quest to use gene therapy to enable people born deaf to hear.

19 May 2021

Antibody response following SARS-CoV-2 mRNA vaccine is greater than natural infection

Researchers in the United States have provided the first evidence that messenger RNA (mRNA)-based vaccines against severe acute respiratory coronavirus 2 (SARS-CoV-2) induce a broader array of antibody subtypes against the viral spike protein than natural infection does.

19 May 2021

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

A team of scientists from the USA and Belgium has recently revealed that the ErbB family of receptor tyrosine kinases play a vital role in regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle in host cells and that inhibition of these receptors can protect against SARS-CoV-2-induced acute and chronic lung injuries and inflammation.

18 May 2021

Enhanced version of CureVac’s COVID-19 vaccine could help address supply shortages

Researchers in Germany have demonstrated the preclinical effectiveness of a next-generation coronavirus disease 2019 (COVID-19) vaccine at enhancing antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 May 2021

Researchers develop a hairpin-shaped bicyclic peptide to fight cancer

The inhibition of pathological protein-protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer.

12 May 2021

Researchers identify first biomarker to predict severity of COVID-19

Severe cases of COVID-19 can now be detected at an early stage. Researchers at the University of Zurich have identified the first biomarker that can reliably predict which patients will develop severe symptoms.

10 May 2021

Scientists investigate signal necrotic cells that cue phagocytic cells to engulf the dying cell

Just as people keep their houses clean and clutter under control, a crew of cells in the body is in charge of clearing the waste the body generates, including dying cells. The housekeeping cells remove unwanted material by a process called phagocytosis, which literally means 'eating cells.' The housekeepers engulf and ingest the dying cells and break them down to effectively eliminate them.

7 May 2021

Researchers provide a promising new way to elucidate the brain's health

Researchers from the Center for BrainHealth at The University of Texas at Dallas are investigating a potential new early indicator of the decline toward Alzheimer's disease: measuring the energy metabolism of the living human brain using cutting-edge imaging techniques.

4 May 2021

"COVID-19 diarrhea" depends on inflammatory response that is part of the disease

Researchers in the United States have provided important insights into the pathophysiology of diarrhea that occurs in some cases of coronavirus disease 2019 (COVID-19).

29 Apr 2021

Nanobodies may be the key to blocking tick-borne bacterial infection

Tiny molecules called nanobodies, which can be designed to mimic antibody structures and functions, may be the key to blocking a tick-borne bacterial infection that remains out of reach of almost all antibiotics, new research suggests.

28 Apr 2021

Can control theory explain differences in virulence and transmission of SARS-CoV-2?

A new study discusses variations in viral pathogenicity and in transmission, which are responsible for asymptomatic infection and for superspreading events. The ability to understand this would open the way to understand how this virus behaves the way it does, in terms of its virulence, its spread, and its emergent variants of concern.

28 Apr 2021

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

New research led by Hana El-Samad of the University of California, San Francisco, and the Chan-Zuckerberg Biohub confirmed the beneficial use of an antiviral therapeutic called SARSNotch, which uses a combination of the SynNotch platform and de-novo designed protein binders. SARSNotch uses sentinel T cells to detect and mount a genetic response toward the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

28 Apr 2021

Scientists gain atomic-level insight into behavior of a protein that promotes cancer growth

The neutron reflexometry method has given scientists an atomic-level insight into the behavior of Bcl-2, a protein that promotes cancerous cell growth. The new study was carried out by Umeå chemists in collaboration with the research facilities ESS and ISIS and is published in Nature Communications Biology.

28 Apr 2021

New discovery could lead to more effective treatments for fatigue-inducing anemias

A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests.

27 Apr 2021

Researchers develop a method of fabrication for biodegradable polymer microcapsules

An international team led by a Skoltech researcher has developed a method of fabrication for biodegradable polymer microcapsules, made more efficient by turning to an unusual source of inspiration - traditional Russian dumpling, or pelmeni, making.

23 Apr 2021

Research data may provide new treatment options for hormone-dependent breast cancer

Notch proteins are key regulators of growth and differentiation of both normal and cancer cells. Researchers in Turku, Finland, have now demonstrated that the activities of distinct Notch family members are modified differently by phosphorylation.

22 Apr 2021

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

The lack of new or repurposed drugs to treat patients with severe or critical COVID-19 has been one of the biggest hurdles to reducing mortality rates in the ongoing pandemic caused by SARS-CoV-2. A new study describes the potential for the use of the plant molecule isorhamnetin in the management of this virus.

19 Apr 2021

Researchers identify new targets to control angiogenesis

Angiogenesis is a process of new vessel formation that is activated both in physiological (tissue repair, reproduction, etc.) and pathological (myocardial infarction, diabetic retinopathy, cancer, etc.) conditions.

16 Apr 2021

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis.

15 Apr 2021

Intracellular News and Research

New level of control over stem cells will help accelerate research, lead to therapeutic applications

Researchers find new clue to restore congenital hearing loss

Antibody response following SARS-CoV-2 mRNA vaccine is greater than natural infection

ErbB inhibitor lapatinib exhibits potent anti-SARS-CoV-2 activity

Enhanced version of CureVac’s COVID-19 vaccine could help address supply shortages

Researchers develop a hairpin-shaped bicyclic peptide to fight cancer

Researchers identify first biomarker to predict severity of COVID-19

Scientists investigate signal necrotic cells that cue phagocytic cells to engulf the dying cell

Researchers provide a promising new way to elucidate the brain's health

"COVID-19 diarrhea" depends on inflammatory response that is part of the disease

Nanobodies may be the key to blocking tick-borne bacterial infection

Can control theory explain differences in virulence and transmission of SARS-CoV-2?

Scientists design 'smart' cellular biosensors for detecting SARS-CoV-2 spike

Scientists gain atomic-level insight into behavior of a protein that promotes cancer growth

New discovery could lead to more effective treatments for fatigue-inducing anemias

Researchers develop a method of fabrication for biodegradable polymer microcapsules

Research data may provide new treatment options for hormone-dependent breast cancer

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

Researchers identify new targets to control angiogenesis

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

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