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New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

A team of University of Michigan researchers is developing a new anti-cancer drug that is absorbed through the gut's lymphatic system rather than blood vessels, potentially outmaneuvering the molecular signaling pathways that lead to drug resistance while increasing cancer-fighting ability and reducing side effects.

17 Aug 2022

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands.

16 Aug 2022

Study uncovers a key role for MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy

A study carried out by scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and led by Dr. Guadalupe Sabio has identified a key role for the MKK3/6–p38γ/δ signaling pathway in the development of cardiac hypertrophy.

16 Aug 2022

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

In a new study, researchers explored sphingosine kinases inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry.

16 Aug 2022

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

In newly released research, scientists assessed the cardiac effects of remdesivir.

12 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

9 Aug 2022

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

A recent study published in Cell illustrated a human genome map with dosage sensitivity across disorders.

9 Aug 2022

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Scientists review current literature associated with the role of the gut-brain axis in AD pathogenesis.

9 Aug 2022

Study reveals the intertumoral heterogeneity of METex14 skipping positive NSCLCs

A study presented today at the IASLC World Conference on Lung Cancer 2022 in Vienna disclosed the clinical-relevant intertumoral heterogeneity of non-small cell lung cancer (NSCLC) driven by MET exon 14 skipping.

8 Aug 2022

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Investigators from Cedars-Sinai Cancer have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

3 Aug 2022

Tannins as therapeutic agents against SARS-CoV-2

Researchers reviewed tannins as therapeutic agents against SARS-CoV-2.

29 Jul 2022

Proteomics profiling of COVID-19 patients identifies dysregulated proteins and pathways

Researchers assessed the impact of SARS-CoV-2 infection and severity on coronary and Alzheimer’s disease pathways.

29 Jul 2022

Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Of the roughly 20,000 people in the U.S. diagnosed with esophageal cancer this year, just 4,000 are likely to still be alive in 2027.

28 Jul 2022

Study: Over half of the online pharmacies selling chemotherapy drugs operate unsafely or illegally

Patients seeking to purchase chemotherapy drugs online face a confusing array of websites, over half of which potentially operate unsafely or illegally, finds a new study in the July 2022 issue of JNCCN - Journal of the National Comprehensive Cancer Network.

28 Jul 2022

Kinase News and Research

New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Study uncovers a key role for MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Study reveals the intertumoral heterogeneity of METex14 skipping positive NSCLCs

Researchers discover two signaling pathways that are downregulated in human hearts after birth

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Tannins as therapeutic agents against SARS-CoV-2

Proteomics profiling of COVID-19 patients identifies dysregulated proteins and pathways

Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Study: Over half of the online pharmacies selling chemotherapy drugs operate unsafely or illegally

Pigment epithelium-derived factor ablations may lead to eye aging

Is monkeypox a global public-health emergency?

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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