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Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has accepted the company's supplemental Biologics License Application for the use of a Perjeta (pertuzumab) regimen before surgery (neoadjuvant treatment) in people with HER2-positive early stage breast cancer.

2 Jul 2013

Researchers discover an important mechanism that regulates proteasome activity

Dysfunction of the ubiquitin-proteasome system (UPS) has been detected in many neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and certain types of cancer. Such dysfunction is also believed to be related to some degenerative muscle diseases. Researchers at the University of Helsinki, Finland, have now discovered an important mechanism that regulates proteasome activity.

1 Jul 2013

Study indicates "statin-intolerant" patients can reduce cholesterol by visiting lipid clinic treatment

Up to 15 percent of patients who take cholesterol-lowering statin medications experience muscle pain or other side effects, and many patients simply stop taking the drugs.

30 Jun 2013

Healthy man injured severely while weight lifting required surgery

A young, healthy man injured himself so severely while weight lifting that he required surgery and nearly a full week in the hospital to recover. The unusual case report of compartment syndrome to the shoulder will be reported online today in Annals of Emergency Medicine ("An Unusual Complication of Weightlifting: A Case Report").

30 Jun 2013

Innovative procedure for atrial fibrillation reduces risk for stroke

The UNC Center for Heart and Vascular Care is the first in North Carolina to use an innovative procedure for people at risk for stroke.

28 Jun 2013

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

A second amyloid may play a role in Alzheimer's disease, UC Davis researchers find. A protein secreted with insulin travels through the bloodstream and accumulates in the brains of individuals with type 2 diabetes and dementia, in the same manner as the amyloid beta (Αβ) plaques that are associated with Alzheimer's disease, a study by researchers with the UC Davis Alzheimer's Disease Center has found.

28 Jun 2013

Janssen receives complete response letter from FDA for XARELTO sNDA

Janssen Research & Development, LLC today announced the U.S. Food and Drug Administration has issued a complete response letter for the supplemental New Drug Application for XARELTO (rivaroxaban) to reduce the risk of stent thrombosis in patients with acute coronary syndrome.

28 Jun 2013

TSRI scientists identify small molecules to control genetic defect responsible for muscular dystrophy

For the first time, scientists from the Florida campus of The Scripps Research Institute have identified small molecules that allow for complete control over a genetic defect responsible for the most common adult onset form of muscular dystrophy.

28 Jun 2013

Stanford researchers take new step in deciphering of histone code

A chemical code scrawled on histones - the protein husks that coat DNA in every animal or plant cell - determines which genes in that cell are turned on and which are turned off.

28 Jun 2013

FDA approves Novartis' Exelon Patch for treatment of severe Alzheimer's disease

The US Food and Drug Administration has expanded the approved indication for Exelon Patch (rivastigmine transdermal system) to include the treatment of people with severe Alzheimer's disease with Exelon Patch 13.3mg/24h.

28 Jun 2013

Scientists make important step forward to find cure for cancer

Scientists at the University of East Anglia have made a major advancement in understanding tissue development that has important implications for cancer.

27 Jun 2013

Eisai submits BELVIQ NDS with Health Canada

Arena Pharmaceuticals, Inc. announced today that Eisai Limited (based in Mississauga, Ontario), a subsidiary of Eisai Inc., has submitted a New Drug Submission for BELVIQ (lorcaserin HCl) with Health Canada.

26 Jun 2013

A paradigm shift for treatment of muscular dystrophy

Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic approach that has proven effective in treating muscular dystrophy in a mouse model.

26 Jun 2013

Researchers develop breakthrough approach to reduce harmful effects from blood transfusions

Researchers from Case Western Reserve University School of Medicine have developed an unprecedented approach to restore nitric oxide to donated blood, a breakthrough that could dramatically reduce harmful effects from transfusions.

26 Jun 2013

Study finds PTSD as risk factor for heart disease among Vietnam vets

Male twin Vietnam veterans with post-traumatic stress disorder were more than twice as likely as those without PTSD to develop heart disease during a 13-year period, according to a study supported by the National Institutes of Health.

26 Jun 2013

Excessive intake of cola and honey can cause fainting and arrhythmia symptoms, shows study

Drinking excessive amounts of cola and eating honey made from the pollen of Rhododendrons can cause unusual syncope (fainting) and symptoms of arrhythmia, report two case studies presented as abstracts at the EHRA EUROPACE 2013 meeting, in Athens 23 to 26 June.

25 Jun 2013

Researchers hope voice therapy in aging humans may help improve quality of life

A new study shows that the vocal training of older rats reduces some of the voice problems related to their aging, such as the loss of vocal intensity that accompanies changes in the muscles of the larynx. This is an animal model of a vocal pathology that many humans face as they age.

25 Jun 2013

CytRx reaches targeted enrollment in aldoxorubicin Phase 2b study for treatment of soft tissue sarcoma

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, announced that it has reached the targeted enrollment of 105 evaluable patients in its international Phase 2b clinical trial with aldoxorubicin as a first-line treatment for soft tissue sarcoma.

25 Jun 2013

Researcher receives NINDS grant to develop DTI for pediatric spinal cord injury diagnosis

Most of the 11,000 new cases of spinal cord injury that are diagnosed each year in the United States occur in people under age 30, and often the sufferer is a child. But smaller spinal cords in children and a lack of adequate imaging technology has created major problems in precisely locating the site of injury. New technological developments in imaging could help clinical specialists design more effective treatment and rehabilitation strategies for pediatric patients.

21 Jun 2013

Researchers monitor dynamic cellular events that take place during cardiac regeneration in zebrafish

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.

20 Jun 2013

Muscle News and Research

Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

Researchers discover an important mechanism that regulates proteasome activity

Study indicates "statin-intolerant" patients can reduce cholesterol by visiting lipid clinic treatment

Healthy man injured severely while weight lifting required surgery

Innovative procedure for atrial fibrillation reduces risk for stroke

Study suggests amylin deposits are a new biomarker for age-related dementia and Alzheimer's

Janssen receives complete response letter from FDA for XARELTO sNDA

TSRI scientists identify small molecules to control genetic defect responsible for muscular dystrophy

Stanford researchers take new step in deciphering of histone code

FDA approves Novartis' Exelon Patch for treatment of severe Alzheimer's disease

Scientists make important step forward to find cure for cancer

Eisai submits BELVIQ NDS with Health Canada

A paradigm shift for treatment of muscular dystrophy

Researchers develop breakthrough approach to reduce harmful effects from blood transfusions

Study finds PTSD as risk factor for heart disease among Vietnam vets

Excessive intake of cola and honey can cause fainting and arrhythmia symptoms, shows study

Researchers hope voice therapy in aging humans may help improve quality of life

CytRx reaches targeted enrollment in aldoxorubicin Phase 2b study for treatment of soft tissue sarcoma

Researcher receives NINDS grant to develop DTI for pediatric spinal cord injury diagnosis

Researchers monitor dynamic cellular events that take place during cardiac regeneration in zebrafish

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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