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Manipulating cancer cell metabolism may help combat DIPGs and other brain tumors

Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures.

18 Aug 2020

Study shows how bacteria become increasingly infectious under certain conditions

Bacteria that invade animal cells in order to multiply are widespread in nature. Some of these are pathogens of humans and animals. In the environment, they are often found inside unicellular organisms.

18 Aug 2020

Identifying Alzheimer’s risk factors in young people

News-Medical speaks to the Alzheimer's association about their research which looked at risk factors that could aid in the early detection of Alzheimer's.

18 Aug 2020

Researchers identify shared molecular roots between lipid dysfunction and autism

Researchers at Harvard Medical School, Massachusetts Institute of Technology and Northwestern University have identified a subtype of autism arising from a cluster of genes that regulate cholesterol metabolism and brain development.

18 Aug 2020

Researchers identify new therapeutic target for Alzheimer's disease

Scientists at St. Jude Children's Research Hospital are advancing understanding of a potential Alzheimer's disease treatment.

18 Aug 2020

Researchers solve a long-held mystery of X chromosome inactivation

Researchers at Massachusetts General Hospital (MGH) have solved a mystery that has long puzzled scientists: How do the bodies of female humans and all other mammals decide which of the two X chromosomes it carries in each cell should be active and which one should be silent?

18 Aug 2020

Discovery offers new hope for millions at risk from antibiotic-resistant infections

There is new hope for approximately 700,000 people who die each year from antibiotic resistant infections, with University of Queensland researchers discovering how bacteria share antibiotic-resistance genes.

17 Aug 2020

Switching off 'master regulator' may protect critical brain cells from Parkinson's-related damage

Switching off a molecular "master regulator" may protect the brain from inflammatory damage and neurodegeneration in Parkinson's disease, reports a study published today in Nature Neuroscience.

17 Aug 2020

Multiplication of ecDNA genes present in many cancer types, drives poor patients outcomes

The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a team of researchers including Professors Vineet Bafna and Dr.Paul Mischel of the University of California San Diego and Professor Roel Verhaak of Jackson Laboratories.

17 Aug 2020

Cashew shell compound may help repair damaged nerves

In laboratory experiments, a chemical compound found in the shell of the cashew nut promotes the repair of myelin, a team from Vanderbilt University Medical Center reports today in the Proceedings of the National Academy of Sciences.

17 Aug 2020

New test could help predict survival of women with ovarian cancer

A global team of medical researchers led by UNSW have developed a test that could help to predict survival for women diagnosed with ovarian cancer, and pave the way towards personalized treatment.

17 Aug 2020

Deciphering the largest CRISPR system

Professor Guillermo Montoya spoke to News-Medical on his research that involved visualizing the largest and most complex CRISPR system.

17 Aug 2020

Genome analysis helps detect 568 genes that drive cancer

Analysis of the genomes of 28,000 tumors from 66 types of cancer has led to the identification of 568 cancer driver genes

17 Aug 2020

Standardized guidelines for phage therapy can speed up lifesaving treatment

When clinicians resort to phage therapy for patients who don't respond to antibiotics, the patients are usually very ill and time is of the essence. But the average time for labs to produce therapeutic phages is more than a month.

17 Aug 2020

Coronacept - A trap-and-destroy molecule against SARS-CoV-2

A new study published on the preprint server bioRxiv* in August 2020 reports a novel engineered molecule based on human and other mammalian orthologues of ACE2 fused with the Fc part of the antibody. This molecule interacts more tightly with the viral receptor-binding domain (RBD) to constitute a powerful immunoadhesin that targets the virus for destruction.

17 Aug 2020

PARP inhibitor can successfully treat a subset of advanced prostate cancer patients

Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known as rucaparib, resulting in recent FDA approval.

15 Aug 2020

COVID-19 virus acts as a 'sponge' to deplete specific host microRNAs

Why is the COVID-19 virus deadly, while many other coronaviruses are fairly innocuous and just cause colds?

15 Aug 2020

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration.

15 Aug 2020

Scientists hope to find clues about how life emerged by tinkering with its oldest components

"I'm fascinated with life, and that's why I want to break it."

15 Aug 2020

Influenza-virus-based vaccine platform another viable option against SARS-CoV-2

In a novel proof of concept study, published on the bioRxiv preprint server, U.S. researchers used attenuated influenza viral particles that express severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain to induce neutralizing antibodies in mice – unveiling another viable vaccine candidate for preventing coronavirus disease (COVID-19).

14 Aug 2020

Genes News and Research

Manipulating cancer cell metabolism may help combat DIPGs and other brain tumors

Study shows how bacteria become increasingly infectious under certain conditions

Identifying Alzheimer’s risk factors in young people

Researchers identify shared molecular roots between lipid dysfunction and autism

Researchers identify new therapeutic target for Alzheimer's disease

Researchers solve a long-held mystery of X chromosome inactivation

Discovery offers new hope for millions at risk from antibiotic-resistant infections

Switching off 'master regulator' may protect critical brain cells from Parkinson's-related damage

Multiplication of ecDNA genes present in many cancer types, drives poor patients outcomes

Cashew shell compound may help repair damaged nerves

New test could help predict survival of women with ovarian cancer

Deciphering the largest CRISPR system

Genome analysis helps detect 568 genes that drive cancer

Standardized guidelines for phage therapy can speed up lifesaving treatment

Coronacept - A trap-and-destroy molecule against SARS-CoV-2

PARP inhibitor can successfully treat a subset of advanced prostate cancer patients

COVID-19 virus acts as a 'sponge' to deplete specific host microRNAs

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

Scientists hope to find clues about how life emerged by tinkering with its oldest components

Influenza-virus-based vaccine platform another viable option against SARS-CoV-2

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