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Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health totaling more than $5.5 million to develop new treatments for two types of devastating parasitic infections common in sub-Saharan Africa and Central and South America: river blindness and intestinal worm infections.

22 Dec 2021

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Boosting levels of the neurotransmitter norepinephrine with atomoxetine, a repurposed ADHD medication, may be able to stall neurodegeneration in people with early signs of Alzheimer's disease, a study conducted at Emory Brain Health Center suggests.

22 Dec 2021

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

A newly discovered species of antibiotic-resistant bacteria has been named after the academic institute where it was identified – the John Innes Centre.

22 Dec 2021

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.

22 Dec 2021

KHN’s ‘What the Health?’: Manchin blows up Biden’s ‘Build Back Better’

Sen. Joe Manchin (D-W.Va.) dashed the hopes of President Joe Biden and congressional Democrats for passage of the giant "Build Back Better" bill before the end of the year, when he announced his opposition to the measure in an interview on "Fox News Sunday."

22 Dec 2021

Researchers identify new mechanism that impairs cancer cell proliferation and induces death

UAB and Vall d'Hebron researchers identified the mechanism by which inhibitors of the ERK5 protein kinase impair the proliferation of cancer cells and induce their death. The results, obtained using human cancer cell lines, demonstrate that ERK5 inhibition activates cytotoxic autophagy, a process that triggers cancer cell death, without affecting healthy cells. A combination of ERK5 inhibitors and chemotherapy could improve cancer treatment.

22 Dec 2021

Reprogramming immune system cells to strengthen against infections and cancer in geriatric patients

What if the key to aging well lies in reprogramming immune system cells to strengthen them against infections and cancer? Researchers at UT Southwestern are working to find out.

22 Dec 2021

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Wilmot Cancer Institute researchers are a step closer to understanding the complex gene interactions that cause a cell to become malignant.

21 Dec 2021

Proportion of ‘frequent attenders’ has risen over the past two decades, study reveals

'Frequent attenders' now make up around 4 in every 10 family doctor (GP) consultations in England, and the proportion of such patients has risen over the past two decades, reveals a large long term study published in the open access journal BMJ Open.

21 Dec 2021

Doctors advised to prescribe fewer antidepressants and for shorter periods of time

Doctors should prescribe fewer antidepressants and for shorter periods of time, because of the ongoing uncertainties about their effectiveness and the potential severity and durability of the withdrawal symptoms associated with them, suggests a review of the evidence on antidepressant use, published online in the Drug and Therapeutics Bulletin.

21 Dec 2021

Promising new drug target for TB identified

Mycobacterium tuberculosis (Mtb), the hardy bacterial species that causes tuberculosis (TB), has an unexpected vulnerability that future drugs may be able to exploit, according to a study from researchers at Weill Cornell Medicine.

21 Dec 2021

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

The results of a nationwide, multicenter clinical trial led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health provides solid evidence for the use of plasma from convalescent patients — those who have recovered from the disease and whose blood contains antibodies against SARS-CoV-2, the virus that causes COVID-19 — as an early treatment.

21 Dec 2021

FDA approval of long-acting injectable drug marks a vital expansion of HIV prevention options

Yesterday the U.S. Food and Drug Administration announced its first approval of a long-acting HIV prevention medication. Developed by ViiV Healthcare, the medicine is long-acting cabotegravir injected once every two months.

21 Dec 2021

Molecular mechanism of SARS-Cov-2-induced thrombosis

Researchers demonstrate that the exposure of platelets to the SARS-CoV-2 spike protein promotes their activation and adhesion.

21 Dec 2021

INTEGRA supports groundbreaking brain tumor research

INTEGRA Biosciences is proud to be supporting vital translational research into diffuse intrinsic ponsglioma (DIPG) – a rare childhood brain tumor – at the Ludwig Maximilian University of Munich (LMU) with a festive donation of 20,000 EUR.

From INTEGRA Biosciences 21 Dec 2021

Covered California’s insurance deals range from ‘no-brainer’ to sticker shock

If you purchase your own health insurance, it's time to choose your coverage for 2022. If you buy it through Covered California, the chances are better than ever that you will get a big discount on your monthly premium — or pay no premium at all.

21 Dec 2021

$Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma$

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Early results from an Alliance for Clinical Trials in Oncology randomized clinical trial of adults with multiple myeloma relapsing on frontline lenalidomide therapy showed that adding ixazomib (Ninlaro®) to pomalidomide and dexamethasone as part of second line therapy extended the length of time patients lived before their disease worsened (progression-free survival) compared with patients who received pomalidomide and dexamethasone.

21 Dec 2021

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer's disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer's prevention trials, this one will enroll people before the disease has taken hold - up to 25 years before the expected onset of dementia.

21 Dec 2021

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Overweight or obesity, an unfavorable distribution of fat in the body and the development of type 2 diabetes are often associated with a reduced effect of the hormone insulin in many organs, including the brain (insulin resistance).

21 Dec 2021

Researchers find a digital silver lining in failed COVID-19 drug trial

A clinical trial in which two test drugs failed to help patients with mild COVID-19 nevertheless had a silver lining: It proved the viability of a study model in which a medication's potential arrhythmic side effects are safely, effectively monitored without the participants ever setting foot in a hospital or clinic.

20 Dec 2021

Drugs News and Research

Researchers receive NIH grants to develop new treatments for neglected tropical diseases

Study points toward an alternative drug strategy to stall Alzheimer’s neurodegeneration

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

Amino acid valine plays a key role in the growth of T cell acute lymphoblastic leukemia

KHN’s ‘What the Health?’: Manchin blows up Biden’s ‘Build Back Better’

Researchers identify new mechanism that impairs cancer cell proliferation and induces death

Reprogramming immune system cells to strengthen against infections and cancer in geriatric patients

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Proportion of ‘frequent attenders’ has risen over the past two decades, study reveals

Doctors advised to prescribe fewer antidepressants and for shorter periods of time

Promising new drug target for TB identified

Early administration of SARS-CoV-2 convalescent plasma reduces outpatient hospitalizations

FDA approval of long-acting injectable drug marks a vital expansion of HIV prevention options

Molecular mechanism of SARS-Cov-2-induced thrombosis

INTEGRA supports groundbreaking brain tumor research

Covered California’s insurance deals range from ‘no-brainer’ to sticker shock

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Researchers find a digital silver lining in failed COVID-19 drug trial

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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