Anticoagulant News and Research

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Fosamax use linked to atrial fibrillation in women

Women who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat (atrial fibrillation) than are those who have never used it, according to research from Group Health and the University of Washington published in the April 28 Archives of Internal Medicine.

28 Apr 2008

Study looks at use of powerful anticoagulants to prevent pulmonary embolism

Current US guidelines for the prescription of potent anticoagulants by surgeons who perform joint replacement operations could be doing patients more harm than good, according to Dr. Nigel Sharrock and his team from the Hospital for Special Surgery in New York.

1 Apr 2008

Comparison of anticoagulants for angioplasty show similar outcomes

In a comparison of anticoagulants and stents for use with angioplasty following a heart attack, the anticoagulants abciximab and tirofiban had similar outcomes for some cardiac measures within 90 minutes after the procedure, while patients who received stents that released the drug sirolimus had a lower risk of major adverse cardiac events within 8 months than patients who received uncoated stents, according to a JAMA study being released early online March 30 to coincide with its presentation at the annual conference of the American College of Cardiology.

31 Mar 2008

Discovery of potential drug targets for sepsis

"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," says Scripps Research Professor Wolfram Ruf, who led the research with his postdoctoral fellow Frank Niessen.

28 Feb 2008

Discovery of a new anticoagulant

The discovery of a new anticoagulant with promising therapeutic value is reported on the 20th of February issue of the journal PLoS ONE1.

20 Feb 2008

Researchers find protein targets for potential treatment of multiple sclerosis

Multiple sclerosis is not a single condition, but an ebbing and flowing of stages affecting the body ' s central nervous system.

18 Feb 2008

Study examines computed tomographic pulmonary angiography for diagnosing blood clots in the lung

New research indicates that a diagnostic strategy using computed tomographic pulmonary angiography (CTPA) may be a safe alternative to conventional lungs scans (known as ventilation-perfusion scans) for excluding the diagnosis of pulmonary embolism (blood clots in the lung vessels), although CTPA may detect more clots, according to a study in the current issue of JAMA: The Journal of the American Medical Association.

20 Dec 2007

Safe and effective therapy discovered for patients with protein-losing enteropathy

Researchers at the Burnham Institute for Medical Research (Burnham Institute) have developed the first model to study intestinal protein leakage in mice, allowing the team to control and replicate both genetic deficiencies and environmental damages in an in vivo setting.

10 Dec 2007

Lenalidomide - dexamethasone combination effective against multiple myeloma

Pairing a new thalidomide derivative with a steroid slows progress of multiple myeloma, an incurable bone marrow cancer, and prolongs the lives of patients who have relapsed from previous treatment, researchers report in the Nov. 22 New England Journal of Medicine.

21 Nov 2007

Anticoagulant bivalirudin following angioplasty in heart attack patients reduces adverse events and bleeding

Late-breaking data presented at TCT 2007, the scientific symposium of the Cardiovascular Research Foundation (CRF), show that the use of the anticoagulant bivalirudin following angioplasty in heart attack patients reduces net adverse clinical events by 24 percent compared to the standard treatment, and significantly reduces major bleeding that occurs after angioplasty by 40 percent.

24 Oct 2007

Landmark stent trial to be presented at TCT 2007

The Cardiovascular Research Foundation (CRF) will release results of its landmark research study, HORIZONS AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) at the nineteenth annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium in Washington, D.C.

16 Oct 2007

Simple tool improves communication between doctors and patients

A UCSF research team has developed a simple tool that can improve the effectiveness of communication between doctors and patients about prescribed medications and result in dramatic improvements in health and safety.

29 Sep 2007

Snake venom composition may change according to the victim

A snake's intended prey might affect the type and evolution of toxins in their venom, research published in the online open access journal BMC Evolutionary Biology shows.

27 Sep 2007

Risk of venous thrombosis after air travel exaggerated

In a paper published this week in the open-access journal PLoS Medicine Frits Rosendaal and colleagues from Leiden University Medical Center, Academic Medical Center Amsterdam and Nestle Medical Services, provide the first absolute estimate of risk of venous thrombosis after air travel.

26 Sep 2007

Risk of DVT on planes so small... not worth taking pills

The debate over the health risks associated with long-haul flights is in the news again with research from Holland.

25 Sep 2007

New synthetic version of the drug heparin

Researchers at the University of North Carolina at Chapel Hill have patented a synthetic version of the drug heparin, called Recomparin, that is less complex chemically and should be easier to produce than previous forms.

24 Sep 2007

Pocket guidelines for assessment and management of cardiovascular risk

A new book of pocket-charts that will help health workers to identify people at risk of heart attacks and strokes and save lives by prescribing the most appropriate treatment is published today by the World Health Organization (WHO). The charts can be adapted for use in any setting, in any country, with any patient.

12 Sep 2007

Improved dosing formula for warfarin (Coumadin)

Doctors prescribing blood thinners have had to go through a lengthy trial-and-error process to arrive at the optimal dose for their patients.

5 Sep 2007

Genetic-based dosing in orthopedic patients beginning warfarin therapy

Doctors prescribing blood thinners have had to go through a lengthy trial-and-error process to arrive at the optimal dose for their patients. But now the process can be faster and safer, thanks to research conducted at Washington University School of Medicine in St. Louis.

3 Sep 2007

Genetics determine optimal drug dose of warfarin

Genetic testing can be used to help personalize the therapeutic dosage of warfarin, a commonly-used anticoagulant, according to research published in the September 1, 2007, issue of Blood , the journal of the American Society of Hematology.

22 Aug 2007