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Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Researchers develop E. coli cell line that produces large quantities of compound serine

If you had a company that manufactured valuable ingredients for chemicals like detergens or paint, you would probably like to produce the ingredients in large quantities, sustainably, and at a low cost. That's what researchers from The Novo Nordisk Foundation Center for Biosustainability -- DTU Biosustain -- at DTU can now do.

11 Jan 2017

NYSCF and PGP announce availability of unique new stem cell resource for scientific research

The New York Stem Cell Foundation Research Institute and the Personal Genomes Project today announced the availability of a unique new stem cell resource for scientists around the world.

6 Jan 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

Duke researchers develop new cell-based drug screening test for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body.

8 Dec 2016

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Researchers at the University of Southampton have engineered cells with a 'built-in genetic circuit' that produces a molecule that inhibits the ability of tumours to survive and grow in their low oxygen environment.

24 Nov 2016

Problems with nuclear membrane play role in leukemia, heart disease and aging disorders

We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane.

2 Nov 2016

Nova Bioprofile FLEX autosampler helps achieve significant productivity improvement via dynamic feeding media optimization

Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients.

31 Oct 2016

Researchers identify existing drugs that appear to prevent aggressive subtype of pediatric brain tumors

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer.

27 Oct 2016

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Cedars-Sinai regenerative medicine investigators have received approval from the U.S. Food and Drug Administration to test a combination stem cell-gene therapy they developed to stall the progression of amyotrophic lateral sclerosis, a neurological disease that causes progressive paralysis and ultimately death.

21 Oct 2016

Cancer cell's shape may offer clues for precise prognosis

Doctors can sometimes use a cancer cell's genetics to predict how it will act - how dangerous it is and thus what treatments should be used against it.

20 Oct 2016

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease.

19 Oct 2016

Novel microwave-induced photodynamic therapy could target deeply situated tumors

Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within solid tumors.

12 Oct 2016

New image analysis technique helps better identify and distinguish between two cancer cell types

Brown University researchers have developed a new image analysis technique to distinguish two key cancer cell types associated with tumor progression.

12 Oct 2016

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate stubborn reservoirs of breast and ovarian cancer stem cells (CSCs).

4 Oct 2016

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease.

30 Sep 2016