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Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products. But antibodies are large, complex proteins that can be expensive to manufacture.

2 Mar 2017

Researchers find novel, non-invasive approach for diagnosis and prognosis of prostate cancer

In a new paper in Springer's Journal of Materials Science, researchers at Washington State University report a new approach for the effective capture of tumor-derived exosomes from a prostate cancer cell line.

21 Feb 2017

Yale researchers find potential new way to combat brain cancer

A recent Yale study may have found a new way to fight brain cancer.

15 Feb 2017

Neurotrophic factor GDNF regulates dopamine neurons in the brain, research shows

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems.

15 Feb 2017

Study suggests that iPSCs do not develop more mutations than subcloned cells

It's been more than 10 years since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., developed the breakthrough technique to return any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body.

8 Feb 2017

Johns Hopkins researchers create mature cardiomyocytes in the laboratory from stem cells

Generating mature and viable heart muscle cells from human or other animal stem cells has proven difficult for biologists.

26 Jan 2017

Penn researchers discover antimicrobial that thwarts Zika viral entry into human cells

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Researchers develop E. coli cell line that produces large quantities of compound serine

If you had a company that manufactured valuable ingredients for chemicals like detergens or paint, you would probably like to produce the ingredients in large quantities, sustainably, and at a low cost. That's what researchers from The Novo Nordisk Foundation Center for Biosustainability -- DTU Biosustain -- at DTU can now do.

11 Jan 2017

NYSCF and PGP announce availability of unique new stem cell resource for scientific research

The New York Stem Cell Foundation Research Institute and the Personal Genomes Project today announced the availability of a unique new stem cell resource for scientists around the world.

6 Jan 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

Duke researchers develop new cell-based drug screening test for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body.

8 Dec 2016

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Researchers at the University of Southampton have engineered cells with a 'built-in genetic circuit' that produces a molecule that inhibits the ability of tumours to survive and grow in their low oxygen environment.

24 Nov 2016

Problems with nuclear membrane play role in leukemia, heart disease and aging disorders

We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane.

2 Nov 2016

Nova Bioprofile FLEX autosampler helps achieve significant productivity improvement via dynamic feeding media optimization

Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients.

31 Oct 2016

Researchers identify existing drugs that appear to prevent aggressive subtype of pediatric brain tumors

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer.

27 Oct 2016

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Cedars-Sinai regenerative medicine investigators have received approval from the U.S. Food and Drug Administration to test a combination stem cell-gene therapy they developed to stall the progression of amyotrophic lateral sclerosis, a neurological disease that causes progressive paralysis and ultimately death.

21 Oct 2016