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Blood return system dramatically reduces blood loss during pulmonary thrombectomy

The first comparative analysis from the ENGULF (A Safety and Feasibility Single-Arm Study of a Novel Catheter Thrombectomy Device For the Treatment of Pulmonary Embolism) trial shows that using blood return during continuous aspiration thrombectomy dramatically reduces blood loss by 97%, while maintaining hemodynamic efficacy and improving procedural efficiency.

24 Apr 2026

Exploiting a new weakness in 'zombie-like' cells to treat senescence-associated diseases

A new set of drugs exploit a recently-revealed weakness in 'zombie-like' – or senescent – cells that could lead to new treatments for cancer and age-associated diseases.

24 Apr 2026

New mouse model reveals primary trigger of rare muscle disorder

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

24 Apr 2026

Type 1 diabetes preserves fitness but alters oxygen use in teens

The study highlights early microvascular impairment in adolescents with type 1 diabetes, emphasizing the importance of monitoring vascular health in this group.

24 Apr 2026

"Domino" heart valves from diseased organs could save thousands of children

A surgical innovation called partial heart transplantation could transform care for children with severe heart valve disease, allowing for thousands of additional valve transplants each year, according to a presentation delivered today by Joseph Turek, MD, PhD, at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

24 Apr 2026

Study identifies new genetic pathways driving cardiometabolic disease risk

A study published today in PLOS Medicine has identified two new genetic pathways that contribute to cardiometabolic disease, which includes heart disease, obesity and diabetes.

23 Apr 2026

Study links polyploid cancer cells to tumor invasion and spread

One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment.

23 Apr 2026

Hyperbaric oxygen therapy shows dual effects in glioblastoma treatment

Glioblastoma remains a highly challenging malignancy with a pronounced tendency for recurrence. The hypoxic microenvironment is a key contributor to its therapy resistance.

23 Apr 2026

Revisiting memories together improves emotional wellbeing in dementia care

Caring for a family member with dementia can feel like losing a loved one who is still alive, but a new study suggests that revisiting memories together through a simple digital tool can help ease that grief and even strengthen the patient-caregiver bond.

23 Apr 2026

APOLLO AI learns from 25 billion medical events to predict future disease

APOLLO is a multimodal temporal foundation model trained on 25.2 billion medical events from 7.2 million patients across 33 years of Mass General Brigham records, integrating 28 medical modalities into unified “virtual patient representations.” Across 322 downstream tasks, the model showed strong performance in disease prediction, treatment-response stratification, hospital operations, and patient retrieval, supporting the idea of more computable, data-driven medicine.

23 Apr 2026

Endoscopic procedure may prevent weight regain after GLP-1 discontinuation

An outpatient procedure may offer a way for the estimated 70% of people who discontinue popular weight-loss drugs to avoid regaining the pounds they shed, according to a study to be presented at Digestive Disease Week (DDW) 2026.

23 Apr 2026

Google search trends reflect a shift toward minimally invasive heart care

New research found that public interest in Transcatheter Aortic Valve Replacement (TAVR) increased substantially over the last decade, with Google search volume rising by 340% from 2015 to 2025, while searches for SAVR (Surgical Aortic Valve Replacement) declined by 42%.

23 Apr 2026

Tirzepatide significantly reduces cardiovascular risk in high-risk patients

Two new studies show that tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), significantly reduces cardiovascular risk in high-risk patients, including those undergoing percutaneous coronary intervention (PCI) and those with obesity undergoing transcatheter aortic valve replacement (TAVR).

23 Apr 2026

New human cell model replicates key mechanisms of neurodegenerative diseases

Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies.

23 Apr 2026

Minimally invasive PTAB shows promise for patients with complex peripheral arterial disease

New findings from a DETOUR2 substudy show that minimally invasive percutaneous transmural arterial bypass (PTAB) may offer a promising alternative to traditional leg bypass surgery for patients with complex peripheral arterial disease (PAD), even when distal vessel run off is severely limited.

23 Apr 2026

Study maps the evolution of myeloid leukemia in children with Down syndrome

It may be possible to identify which pre-cancerous cells will develop into a rare type of blood cancer, due to new research showing that a single genetic change drives myeloid leukemia in children with Down syndrome.

23 Apr 2026

Study links ADHD-related traits to increased chronic pain severity

A new study, led by researchers from the University of Tokyo, involving nearly 1,000 patients in Japan suggests that attention deficit hyperactivity disorder (ADHD)-related traits may be associated with and may contribute to chronic pain.

23 Apr 2026

Bioengineered chewing gum reduces cancer-linked oral microbes

Researchers led by Henry Daniell of the School of Dental Medicine have shown that extracts from bioengineered chewing gum reduce the levels of three microbes known to be associated with head and neck squamous cell cancer (HNSCC), paving the way for more effective and affordable therapies.

23 Apr 2026

New gene therapy improves hearing in patients with rare genetic deafness

A new international study co-led by investigators from Mass General Brigham and the Eye & ENT Hospital of Fudan University shows that a gene therapy for a rare form of genetic deafness successfully restored hearing in most participants, with results lasting up to 2.5 years.

23 Apr 2026

Antisense oligonucleotides reverse rare neurodevelopmental disorder in preclinical models

Scientists at St. Jude Children's Research Hospital have found they can reverse the effects of HNRNPH2-related neurodevelopmental disorder using antisense oligonucleotides (ASOs) in preclinical models. ASOs are short synthetic nucleic acid strands that target specific messenger RNA.

22 Apr 2026