Clinical Trial News and Research

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Cardiac clot-busting drug decreases mortality in hemorrhagic stroke patients

Reporting on the results of a phase III international clinical trial, Johns Hopkins Medicine physicians say use of a cardiac clot-busting drug to treat strokes that cause brain bleeding safely decreased the death rate in patients by 10 percent, compared to a control group receiving saline.

23 Feb 2016

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

A medication approved to treat various respiratory diseases and that has demonstrated neuroprotective effects in preclinical studies is the focus of a new clinical trial for Parkinson's disease.

23 Feb 2016

Pitt experts lead gene therapy clinical trial in Parkinson's disease patients

Experts at the University of Pittsburgh School of Medicine are leading the second arm of a clinical trial using gene therapy to relieve the symptoms of tremor and mobility impairment in patients with Parkinson's disease.

23 Feb 2016

Regulus reports net loss of $7.2 million for fourth quarter 2015

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today reported financial results for the fourth quarter and full-year ended December 31, 2015 and provided a summary of recent corporate highlights.

23 Feb 2016

Increasing medication adherence: an interview with Dr Alejandro (Alex) Jaimes

Adherence applies to multiple levels of healthcare. Before a drug goes on the market it has to undergo testing in clinical trials: participants take the study drug and report how well the drug works, along with any side effects.

22 Feb 2016

Patient enrollment completed in vepoloxamer Phase 3 study for treatment of sickle cell disease

Mast Therapeutics, Inc., a biopharmaceutical company developing novel, clinical-stage therapies for sickle cell disease and heart failure today announced that it has completed patient enrollment in its Phase 3 clinical study of vepoloxamer for the treatment of patients with sickle cell disease experiencing vaso-occlusive crisis, known as the EPIC study.

22 Feb 2016

ReCor gets FDA IDE approval to evaluate ReCor Paradise Renal Denervation System in patients with hypertension

ReCor Medical announced today that it has received FDA IDE approval for the RADIANCE-HTN clinical trial to evaluate the effect of the ReCor Paradise Renal Denervation System on blood pressure in patients with hypertension.

22 Feb 2016

Romosozumab for postmenopausal women with osteoporosis meets co-primary endpoints in Phase 3 study

Amgen and UCB today announced top-line results from the Phase 3 placebo-controlled FRActure study in postmenopausal woMen with ostEoporosis (FRAME).

22 Feb 2016

Newly developed intravital microscopy system proves safe for use in humans

A team of Roswell Park Cancer Institute researchers has developed and evaluated the first intravital microscopy system shown to be safe for use in humans. Writing in the journal Nature Communications, the scientists report that their proprietary technology enabled them, for the first time ever, to visualize tumor blood vessels in real time.

22 Feb 2016

Stenting and surgery equally effective at lowering long-term risk of stroke

Investigators for the Carotid Revascularization Endarterectomy versus Stenting Trial found that stenting and surgery are equally effective at lowering the long-term risk of stroke from a narrowed carotid artery, according to a study published today in The New England Journal of Medicine.

22 Feb 2016

Dr. Elliot J. Androphy receives IGNITE grant to develop drug candidate for spinal muscular atrophy

Dr. Elliot J. Androphy, the Kampen-Norins Professor and chair of the Department of Dermatology at the Indiana University School of Medicine, has been awarded an IGNITE, or Innovation Grants to Nurture Initial Translational Efforts, grant by the National Institutes of Health.

22 Feb 2016

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy designation to PKC412 (midostaurin). PKC412 (midostaurin) is an investigational treatment for adults with newly-diagnosed AML who are FLT3 mutation-positive, as detected by an FDA-approved test, and who are eligible to receive standard induction and consolidation chemotherapy.

19 Feb 2016

Physical exercise during pregnancy can prevent gestational hypertension

Researchers at UPM and UWO have shown that performing supervised moderate-intensity exercise during pregnancy can prevent gestational hypertension in pregnant women and overweight in newborns.

19 Feb 2016

FDA-approved Alzheimer's medications may help people quit smoking

Despite several safe drug therapies available to help smokers quit, three-quarters report relapsing within six months of a quit attempt. University of Pennsylvania researchers Rebecca Ashare and Heath Schmidt saw potential for a permanent cessation solution in a class of FDA-approved medications used to improve cognitive impairments from Alzheimer's disease.

19 Feb 2016

Clot-busting drugs decrease mortality in one of worst forms of hemorrhagic stroke

The use of clot-busting drugs to clear blood from the brain's ventricles may be the first effective strategy to decrease mortality for a type of catastrophic bleeding stroke, according to phase-3 clinical trial results announced Thursday at the International Stroke Conference in Los Angeles.

19 Feb 2016

Sanford Health clinical trial testing effectiveness of investigational cancer drug nivolumab

People with Merkel cell, gynecological, gastric and head and neck cancers may be eligible to participate in a clinical trial at Sanford Health testing the effectiveness of an investigational drug called nivolumab.

18 Feb 2016

New treatment protects mice from MERS infection

In a new study, University of Maryland School of Medicine researchers have had promising results with a new treatment for Middle East Respiratory Syndrome (MERS). The study, published today in the journal Science Translational Medicine, found a new treatment that protected mice from MERS infection.

18 Feb 2016

New drug combination shows promise for patients with non-small cell lung cancer

Lung cancer is the most common cause of cancer-related death in the United States resulting in more than 158,000 deaths each year. With a 5-year survival rate at only 18 percent, the development of new and improved treatment options is needed.

18 Feb 2016

Chemotherapy better than chemoradiotherapy in reducing distant pancreatic cancer recurrences

Patients who received chemotherapy after surgical resection of pancreatic cancer have fewer distant disease recurrences and longer overall survival than those who also had adjuvant chemoradiation therapy.

18 Feb 2016

Study reveals another clue to workings of trachoma

Another clue to the workings of trachoma - the world's leading infectious cause of blindness - has been revealed in a new study published in BMC Infectious Diseases. Researchers identified markers of genetic regulation present in the early stages of infection that could predispose children to developing the condition in its long-term, severe form.

17 Feb 2016

Clinical Trial News and Research

Cardiac clot-busting drug decreases mortality in hemorrhagic stroke patients

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

Pitt experts lead gene therapy clinical trial in Parkinson's disease patients

Regulus reports net loss of $7.2 million for fourth quarter 2015

Increasing medication adherence: an interview with Dr Alejandro (Alex) Jaimes

Patient enrollment completed in vepoloxamer Phase 3 study for treatment of sickle cell disease

ReCor gets FDA IDE approval to evaluate ReCor Paradise Renal Denervation System in patients with hypertension

Romosozumab for postmenopausal women with osteoporosis meets co-primary endpoints in Phase 3 study

Newly developed intravital microscopy system proves safe for use in humans

Stenting and surgery equally effective at lowering long-term risk of stroke

Dr. Elliot J. Androphy receives IGNITE grant to develop drug candidate for spinal muscular atrophy

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Physical exercise during pregnancy can prevent gestational hypertension

FDA-approved Alzheimer's medications may help people quit smoking

Clot-busting drugs decrease mortality in one of worst forms of hemorrhagic stroke

Sanford Health clinical trial testing effectiveness of investigational cancer drug nivolumab

New treatment protects mice from MERS infection

New drug combination shows promise for patients with non-small cell lung cancer

Chemotherapy better than chemoradiotherapy in reducing distant pancreatic cancer recurrences

Study reveals another clue to workings of trachoma

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