Protein C News and Research

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Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

Researchers retrieved the first-ever sequenced spike (S) protein structures of the original Wuhan-Hu 1 SARS-CoV-2 strain, the Alpha, Delta, Delta-plus variants, and Omicron sub-variants BA.1 and BA.2 and compared their structural and molecular level variations.

10 May 2022

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Researchers investigated COVID-19-triggered changes in the levels of cyclins and cyclin-dependent kinases inside host cells.

10 May 2022

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

Investigators illustrated that a SARS-CoV-2 Omicron infection post-booster vaccination imparts robust, long-lasting immunity against future re-infections.

10 May 2022

Sphere Fluidics strengthens commercial team with three new senior hires

Key appointments form part of broader ongoing recruitment plans to support expanded operations and product development.

From Fluidic Sciences and Sphere Bio 10 May 2022

Researchers report widespread prevalence of reactive and acute inflammatory CNS microvasculopathy in 36 COVID-19 brain autopsies

A new study has focused on the microcirculatory factors associated with neurological complications of COVID-19.

10 May 2022

Research highlight reports on the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2

A new paper published in Signal Transduction and Targeted Therapy reports the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2.

10 May 2022

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

A study recently published in the journal Cell Host & Microbe has described that all three sublineages of the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit similar host cell entry efficiency and are neutralized equally by antibodies generated in response to coronavirus disease 2019 (COVID-19) booster vaccination

10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

Celebrating contributions to Alzheimer’s research and clinical care

The Mesulam Center for Cognitive Neurology and Alzheimer's Disease held the 28th annual Alzheimer Day on May 5, returning to campus for the first time in three years.

9 May 2022

Study identifies interleukin-6 as a potential target in refining cancer therapies

Immune checkpoint inhibitors have revolutionized the treatment of many cancers by using our body's immune system to kill cancer.

9 May 2022

Exploring low serum volume assays for SARS-CoV-2 antibodies

Researchers developed several non-commercial/in-house low serum volume assays for detecting and characterizing SARS-CoV-2 antibodies.

9 May 2022

Researchers make breakthrough in overcoming drug resistance in a rare, devastating blood cancer

South Australian scientists have made a significant breakthrough in overcoming drug resistance in acute myeloid leukemia (AML), a rare and devastating blood cancer that kills most patients within a few years.

9 May 2022

Third BNT162b2 dose elicits more durable immune response than second dose

Researchers evaluated the durability of immune responses post-third dose of the BNT162b2 vaccine against SARS-CoV-2.

9 May 2022

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Researchers reported on a three-layer designer deoxyribonucleic acid (DNA) nanostructure (DDN) strategy-based sensor designed by them for rapid and accurate SARS-CoV-2 detection and inhibition.

9 May 2022

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, subsequently, metastasis.

9 May 2022

Comparison of COVID-19 vaccination schemes

Researchers assessed SARS-CoV-2 neutralizing antibodies in Chile.

9 May 2022

Researchers investigate IgG antibodies against Mtb proteins in an Asian elephant cured of tuberculosis

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb); the leading cause of human death due to a single pathogen before the emergence of SARS-CoV-2.

9 May 2022

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

Researchers developed a novel protocol to examine dopamine (DA) neurons extracted from Parkinson’s disease (PD) patients using single-cell genomic sequencing.

9 May 2022

Study reveals immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients

A new study aimed to demonstrate the reactivity of COVID-19 serum obtained from patients in Tatarstan, Russia with S and N peptides that were previously identified as immunogenic.

9 May 2022

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in COVID-19 patients.

9 May 2022

Protein C News and Research

Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Heightened antibody responses in COVID-19 booster vaccinated individuals following SARS-CoV-2 Omicron

Sphere Fluidics strengthens commercial team with three new senior hires

Researchers report widespread prevalence of reactive and acute inflammatory CNS microvasculopathy in 36 COVID-19 brain autopsies

Research highlight reports on the observed differences in transmissibility and pathogenicity of Omicron vs. earlier variants of SARS-CoV-2

mRNA boosters enhance neutralization of SARS-CoV-2 BA.1, BA.2 and BA.3

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Celebrating contributions to Alzheimer’s research and clinical care

Study identifies interleukin-6 as a potential target in refining cancer therapies

Exploring low serum volume assays for SARS-CoV-2 antibodies

Researchers make breakthrough in overcoming drug resistance in a rare, devastating blood cancer

Third BNT162b2 dose elicits more durable immune response than second dose

Deoxyribonucleic acid nanostructure sensor found to rapidly detect and inhibit SARS-CoV-2

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Comparison of COVID-19 vaccination schemes

Researchers investigate IgG antibodies against Mtb proteins in an Asian elephant cured of tuberculosis

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

Study reveals immune responses to SARS-CoV-2 peptides in COVID-19 convalescent patients

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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