immunity News and Research

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Reliable immune monitoring tool for assessment of cancer vaccine-induced CD4+ T-cell response

A team of tumor immunologists in France and Switzerland has established an improved, reliable immune monitoring tool that allows for more accurate measurement of the number, subtype, and activity of cancer antigen-specific CD4+ T cells in cancer patients treated with therapeutic cancer vaccines. The new technology may significantly aid tumor immunologists around the world who are working to improve the effectiveness of this emerging and highly promising class of immune system-based cancer therapies.

8 Apr 2010

Variant of ATG16L1 gene associated with higher risk for Crohn's disease

The ATG16L1 gene is located on chromosome 2 and encodes a protein involved in the formation of autophagosomes during autophagy. Autophagy is a cytoplasmic process that keeps a cell stable. Hampe et al first identified ATG16L1 as a Crohn's disease (CD) susceptibility gene in 2007, and many other studies have arisen since then. However, the definite relationship of variants of ATG16L1 with IBD remains unclear.

2 Apr 2010

Indispensable role of Mindin in innate and adaptive immunity

Mindin has an indispensable role in both innate and adaptive immunity. A research group in China investigated regulation of mindin expression and the signaling pathway involved. mRNA expression of mindin was upregulated during dextran sulfate sodium induced mouse intestinal inflammation. Stimulation with CpG-ODN (a known TLR-9 ligand) induced upregulation of mindin expression in RAW 264.7 cells and significantly increased the NF-κB-luciferase activity in vitro.

31 Mar 2010

Gene expression in breast tissue may help explain pregnancy-associated breast cancer

Expression of inflammatory-related genes in breast tissue of women who have previously given birth may explain the aggressiveness and frequency of pregnancy-associated breast cancer, according to new research at the University of Illinois at Chicago.

30 Mar 2010

Inovio Biomedical's total revenue increased to $2.6M for quarter ended December 31, 2009

Inovio Biomedical Corporation today reported financial results for the quarter and year ended December 31, 2009.

29 Mar 2010

Role Tregs play in therapeutic HIV vaccines

Like a skittish driver slamming the brakes, a special class of T cells may be limiting the effectiveness of therapeutic vaccines for HIV by slowing the immune system response too soon, report University of Pittsburgh health science researchers in the current issue of PLoS ONE. Their study, the first to look at the role of regulatory T cells in therapeutic HIV vaccines, may help researchers improve the efficacy of such vaccines by devising methods to circumvent the braking mechanism of these cells.

27 Mar 2010

NIH awards $15M grant to UMDNJ-New Jersey Medical School

For the second time in less than one month, the University of Medicine and Dentistry of New Jersey-New Jersey Medical School has been awarded a coveted $15 million grant by the National Institutes of Health.

27 Mar 2010

Evaluating potential of Ampligen and TLR3 agonists as cancer immunotherapeutics

Hemispherx Biopharma, Inc., announced today the publication of an editorial entitled "TLR3 agonists as immunotherapeutic agents," published in the March 15, 2010 edition of Immunotherapy (2010) 2(2), 137-140, co-authored by Jonathan S. Berek, MD, Chairman, Stanford University School of Medicine Department of Obstetrics and Gynecology, and Christopher F. Nicodemus, MD, Chairman and Chief Scientific Officer, Advanced Immune Therapeutics, Inc., and HEB Consultant.

26 Mar 2010

Optimism may be good for your health

Feeling better about the future might help you feel better for real. In a new study, psychological scientists Suzanne Segerstrom of the University of Kentucky and Sandra Sephton of the University of Louisville studied how law students' expectations about the future affected their immune response.

24 Mar 2010

You and your baby may need vitamin D supplementation says research

This report appeared in the respected Journal Pediatrics this week. There has been growing awareness regarding deficiency of Vitamin D in children and adults. This vitamin is important for healthy bones, immunity and other bodily processes. In children inadequacy of this vitamin in diet may lead to bone damage, rickets, repeated infections and heart disease in later life.

23 Mar 2010

New understanding of cell in immune system may guide creation of effective flu vaccines: Study

A new understanding of a certain cell in the immune system may help guide scientists in creating better flu vaccines, report researchers from the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children's Hospital Boston.

23 Mar 2010

PharmAthene to provide update on contract modification suspension

PharmAthene, Inc., a biodefense company developing medical countermeasures against biological and chemical threats, announced today that in addition to its year end results, it will provide an update on the contract modification suspension it received on Friday, March 19, 2010.

22 Mar 2010

Genes role in protecting intestinal tract from colitis may lead to potential targets for treatment

Scientists report a protein made by a gene already associated with a handful of human inflammatory immune diseases plays a pivotal role in protecting the intestinal tract from colitis.

19 Mar 2010

Advaxis publishes new findings on Listeria-derived ActA anti-cancer component

Advaxis, Inc., the live, attenuated Listeria monocytogenes (Listeria) immunotherapy company, has published new research findings on ActA as a potential, anti-cancer component and a new complement to the Company’s evolving proprietary Listeria technology platform.

19 Mar 2010

Interfering with dickkopf 1 protein may help in controlling inflammatory bowel diseases

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a significantly higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells.

19 Mar 2010

Research shows Caspase-1 protein plays a key role in the process of inflammation and colon cancer

Every day, our gut comes in contact with bacteria, inducing an inflammatory response that is tolerated and controlled. Sometimes the control of inflammation is lost and this can lead to inflammatory bowel disease that may predispose to colon cancer.

18 Mar 2010

Booster shot appears to improve TB resistance in previously vaccinated adults

A booster shot appears to improve tuberculosis (TB) resistance in previously vaccinated adults, according to new research in South Africa.

17 Mar 2010

Cytheris study: rhIL-7 treatment restores T cell trafficking and improves survival in animal model of sepsis

Cytheris SA, a clinical stage biopharmaceutical company focused on research and development of new therapies for immune modulation, today announced publication of data from a preclinical study in a clinically relevant animal model of sepsis showing that recombinant human Interleukin-7 (rhIL-7) treatment not only restores T cell trafficking and function, but also translates into improved survival.

16 Mar 2010

MIT biochemist joins Thomson Reuters’ annual ‘Top 12’ list

The world's "hottest" researcher is biochemist Rudolf Jaenisch from the Massachusetts Institute of Technology. He is joined by scientists scattered from Ann Arbor to Osaka on the annual Thomson Reuters list of the world's 12 hottest researchers.

16 Mar 2010

Obesity limits body's ability to fight infections

Obesity may limit the body's ability to develop immunity to influenza viruses, particularly secondary infections, by inhibiting the immune system's ability to "remember" how it fought off previous similar bouts of illness, according to new research from the University of North Carolina at Chapel Hill.

16 Mar 2010

immunity News and Research

Reliable immune monitoring tool for assessment of cancer vaccine-induced CD4+ T-cell response

Variant of ATG16L1 gene associated with higher risk for Crohn's disease

Indispensable role of Mindin in innate and adaptive immunity

Gene expression in breast tissue may help explain pregnancy-associated breast cancer

Inovio Biomedical's total revenue increased to $2.6M for quarter ended December 31, 2009

Role Tregs play in therapeutic HIV vaccines

NIH awards $15M grant to UMDNJ-New Jersey Medical School

Evaluating potential of Ampligen and TLR3 agonists as cancer immunotherapeutics

Optimism may be good for your health

You and your baby may need vitamin D supplementation says research

New understanding of cell in immune system may guide creation of effective flu vaccines: Study

PharmAthene to provide update on contract modification suspension

Genes role in protecting intestinal tract from colitis may lead to potential targets for treatment

Advaxis publishes new findings on Listeria-derived ActA anti-cancer component

Interfering with dickkopf 1 protein may help in controlling inflammatory bowel diseases

Research shows Caspase-1 protein plays a key role in the process of inflammation and colon cancer

Booster shot appears to improve TB resistance in previously vaccinated adults

Cytheris study: rhIL-7 treatment restores T cell trafficking and improves survival in animal model of sepsis

MIT biochemist joins Thomson Reuters’ annual ‘Top 12’ list

Obesity limits body's ability to fight infections

Industry Focus eBook - Cell biology (5th edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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