Endoplasmic reticulum (ER) News and Research

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RXi to present updated NeuVax Phase II trial data in breast cancer at ASCO 2011

RXi Pharmaceuticals Corporation, a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted and immunotherapy technologies, will be presenting data from the NeuVax Phase II adjuvant breast cancer clinical trial at the 2011 annual meeting of The American Society of Clinical Oncology in Chicago.

19 May 2011

Fewer emergency rooms raises concern

According to a report released Tuesday this week, the number of emergency rooms has dropped by more than a quarter over the past two decades, while patient visits have kept rising. This has resulted in overcrowded ERs that can't provide optimal care for their patients, according to the new findings, published in the Journal of the American Medical Association.

17 May 2011

States struggling with Medicaid costs look for innovation

Florida wants to be the first state in the nation to charge most of its Medicaid recipients a monthly premium as well as $100 for using the ER for routine care. But even supporters acknowledge that the new fees, passed recently by the state legislature as part of a sweeping Medicaid measure, face long odds getting federal approval.

17 May 2011

First Edition: May 16, 2011

Kaiser Health News staff writer Phil Galewitz reports: "Florida wants to be the first state in the nation to charge most of its Medicaid recipients a monthly premium as well as $100 for using the ER for routine care. But even supporters acknowledge that the new fees, passed recently by the state legislature as part of a sweeping Medicaid measure, face long odds getting federal approval".

16 May 2011

Bedside screening tool can help diagnose acute aortic dissection

The most lethal and sudden cardiovascular event can be the toughest for doctors to diagnose. But a study by the University of Michigan Cardiovascular Center shows new guidelines are effective for determining who's most likely suffering from an aortic dissection, which is tearing in the lining of the body's largest blood vessel.

16 May 2011

Karo Bio symposium to discuss research on ER-beta and therapeutic applications

Karo Bio AB is organizing a symposium in Stockholm on May 16-17, where key researchers from the industry and the academic community present and discuss the frontier of research in the field of estrogen receptor beta (ER-beta) and its therapeutic applications.

16 May 2011

Mylan introduces Cyclobenzaprine HCl ER Capsules, a muscle relaxant

Mylan Inc. today announced that its subsidiary Mylan Pharmaceuticals Inc. has launched Cyclobenzaprine Hydrochloride (HCl) Extended-release (ER) Capsules, 15 mg and 30 mg. Mylan was the first company to have filed a substantially complete ANDA containing a Paragraph IV certification for Cyclobenzaprine HCl ER Capsules and was awarded 180 days of marketing exclusivity.

16 May 2011

Researchers uncover unexpected role of estrogen receptors in brain inflammation

Researchers have uncovered an unexpected role for estrogen receptors in the brain in keeping inflammation under control. The findings reported in the May 13 issue of the Cell Press journal Cell may have important implications for the treatment of multiple sclerosis (MS) and many other neurodegenerative diseases.

13 May 2011

Cipher first quarter net revenue decreases to $0.7 million

Cipher Pharmaceuticals Inc. today announced its financial and operational results for the three months ended March 31, 2011.

12 May 2011

Women with invasive breast cancer can benefit from new genomic test

A new genomic test combining multiple signatures - a patient's estrogen receptor status, endocrine therapy response, chemotherapy resistance and sensitivity - shows promise as a predictor of chemotherapy response and survival benefit in women with invasive breast cancer, according to research led by The University of Texas MD Anderson Cancer Center.

11 May 2011

Coffee consumption can reduce risk of ER-negative breast cancer in women

Recently published research shows that coffee drinkers enjoy not only the taste of their coffee but also a reduced risk of cancer with their cuppa. More detailed research published today in BioMed Central's open access journal Breast Cancer Research shows that drinking coffee specifically reduces the risk of antiestrogen-resistant estrogen-receptor-negative breast cancer.

11 May 2011

Simple ultrasound examination may avoid complex tests for children with urinary tract infection

For infants and young children with urinary tract infection seen in the ER, a simple ultrasound examination may avoid the need for more complex x-ray tests, reports a study in the May issue of The Pediatric Infectious Disease Journal.

10 May 2011

Researchers find temperature-sensing protein in immune cells

Researchers at The Scripps Research Institute have found a temperature-sensing protein within immune cells that, when tripped, allows calcium to pour in and activate an immune response.

7 May 2011

AGA honors four young gastroenterologists with prestigious Research Scholar Awards

The American Gastroenterological Association Research Foundation has announced its 2011 research scholars. The grants have been awarded to four outstanding young gastroenterologists who promise to make significant strides in the field of gastrointestinal research.

6 May 2011

Two breast cancer genomic tests produce broadly similar results for high and low-risk patients

Two multi-gene tests designed to predict the risk of disease progression and response to chemotherapy in breast cancer produce broadly similar results for high- and low-risk patients, but do not always agree in their predictions for those at intermediate risk, a new analysis shows.

5 May 2011

Genome epigenetic analysis reveals new ways to detect and treat breast cancer

The most comprehensive analysis yet of the epigenetic modifications present in breast cancer has revealed potentially important new ways to detect and treat the disease, Belgian researchers have reported.

5 May 2011

New training program for nurses to prevent workplace violence

Most people think of hospitals as places for healing. But the threat of violence—which can take many forms—can be a daily reality for nurses and other health care workers, creating a compelling need to properly address the issue, says Kate McPhaul, PhD, MPH, RN, assistant professor and program director for the School of Nursing's Community/Public Health Nursing master's specialty.

30 Apr 2011