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Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

Stanford Medicine investigators have unearthed the biological process by which mRNA-based vaccines for COVID-19 can cause heart damage in some young men and adolescents - and they've shown a possible route to reducing its likelihood.

10 Dec 2025

Surprising new function of immune cells uncovered: Excess weight loss prevention

Researchers at the University of California San Diego School of Medicine have uncovered a surprising new function for immune cells: preventing excess weight loss.

10 Dec 2025

Machine learning models can help diagnose ALS earlier from a blood sample

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests.

10 Dec 2025

Genetic risk score can guide early screening for type 1 diabetes

A test using genetics to predict who is at the highest risk of developing type 1 diabetes could one day be applied to largescale health studies, to identify adults who could benefit from new drugs, new research shows.

9 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators.

9 Dec 2025

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

In a new preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors.

9 Dec 2025

Australian researchers pinpoint specific genetic changes linked to severe AMD

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD).

9 Dec 2025

Patients receiving T-cell redirecting therapies can safely be monitored at home

Patients who receive T-cell redirecting therapies are typically hospitalized for several days after treatment to watch for side effects.

9 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Early-life RSV infection and parental allergy interact to substantially increase childhood asthma risk, supported by population data from more than 1.5 million children and mechanistic mouse experiments. The study shows that viral infection reprograms neonatal immune responses by altering how maternally transferred allergen-specific antibodies are handled, driving long-term allergic airway disease.

8 Dec 2025

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

8 Dec 2025

Combination therapy may boost survival for people with aggressive lymphoma

A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma.

8 Dec 2025

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

A study funded in part by the National Institutes of Health (NIH) has revealed important insights into the genetics of deposits in the eye, known as reticular pseudodrusen (RPD), that are linked to greater risk of vision loss among people with age-related macular degeneration (AMD).

8 Dec 2025

Insufficient sleep may decrease life expectancy

A good night's sleep is more than a luxury: New research from Oregon Health & Science University suggests that insufficient sleep may shorten your life.

8 Dec 2025

Targeted approach of immunotherapy improves sepsis outcomes

Immunotherapy for sepsis is effective when doctors tailor the treatment precisely to the patient's immune system condition.

8 Dec 2025

Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetes

An international research team led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS together with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute) has uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine (TMA).

8 Dec 2025

New trial shows major survival gains with epcoritamab added to standard R2 therapy

In a new trial, patients with follicular lymphoma had a significantly higher response to treatment and a nearly 80% reduction in the risk of death or disease progression if they received epcoritamab in addition to the standard second-line regimen versus the standard regimen alone.

7 Dec 2025

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

A new study suggests that certain genetic differences, passed down from ancient human ancestors, and exposure to common present-day chemicals could explain why some women are more likely to develop endometriosis.

5 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

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Immune System News and Research

Researchers unravel why mRNA-based vaccines for COVID-19 can cause heart damage

Surprising new function of immune cells uncovered: Excess weight loss prevention

Machine learning models can help diagnose ALS earlier from a blood sample

Genetic risk score can guide early screening for type 1 diabetes

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

Australian researchers pinpoint specific genetic changes linked to severe AMD

Patients receiving T-cell redirecting therapies can safely be monitored at home

Online reference library provides a more accurate picture of drug exposure

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

Combination therapy may boost survival for people with aggressive lymphoma

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

Insufficient sleep may decrease life expectancy

Targeted approach of immunotherapy improves sepsis outcomes

Researchers discover a surprising ally in the fight against insulin resistance and type 2 diabetes

New trial shows major survival gains with epcoritamab added to standard R2 therapy

Modern pollutants and ancient genetic variants could explain why some women develop endometriosis

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Understanding the DNA Damage Response in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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