Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Lowering iron content in fat cells prevented mice from gaining excess weight

Lowering iron content in fat cells prevented mice fed a high-fat diet from gaining excess weight and developing associated health problems by limiting the amount of lipids absorbed by the intestines, UT Southwestern scientists report in a new study. The findings, published online in Cell Metabolism, could eventually lead to new strategies to protect people against obesity and related diseases.

29 Jun 2021

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

Change in diet and circadian clock can impact healthy fat tissue, finds study

Changing your eating habits or altering your circadian clock can impact healthy fat tissue throughout your lifespan, according to a preclinical study published today in Nature by researchers with The University of Texas Health Science Center at Houston.

15 Jun 2021

Study implicates placental protein as a possible regulator of an infant’s birthweight

New findings from the University of Minnesota Medical School are helping uncover why some people are more likely to be overweight and develop Type 2 diabetes -- and it starts in the womb.

10 Jun 2021

Increasing a protein concentrated in brown fat may lower diabetes risk

Increasing a protein concentrated in brown fat appears to lower blood sugar, promote insulin sensitivity, and protect against fatty liver disease by remodeling white fat to a healthier state, a new study led by UT Southwestern scientists suggests.

5 Jun 2021

Eating at least two servings of fruit per day reduces diabetes risk by 36%

Researchers at Edith Cowan University revealed that people who consumed at least two servings of fruit per day had higher measures of insulin sensitivity than those who ate less than a half serving. The study, published in the Journal of Clinical Endocrinology and Metabolism, showed that a healthy diet including whole fruits, but not fruit juice, may play a role in mitigating type 2 diabetes risk.

4 Jun 2021

Mice study shows life expectancy can be increased by an average of 30%

Aging is associated with an overall decline in health and increased frailty, and is a major risk factor for multiple chronic diseases.

1 Jun 2021

Can depression increase the likelihood of rapid kidney function decline?

In a recent study, the presence of depressive symptoms in normally healthy individuals was found to correlate with rapid kidney function decline.

1 Jun 2021

Expanding genomic research into different ancestries yields more and better results

Today The Lundquist Institute announced that its investigators contributed data from several studies, including data on Hispanics, African-Americans and East Asians, to the international MAGIC collaboration, composed of more than 400 global academics, who conducted a genome-wide association meta-analysis led by the University of Exeter.

31 May 2021

Blocking ABCB10 protein in liver cells protects against high blood sugar, fatty liver disease

A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice.

20 May 2021

Researchers report promising biotherapeutics for obesity and related medical complications

The research teams at the University of Hong Kong led by Professor Xuechen LI from the Research Division for Chemistry and Department of Chemistry, and Professor Yu WANG from the Department of Pharmacology and Pharmacy, reported a synthetic biotherapeutics with promising anti-tumor, insulin sensitising and hepatoprotective activities in the Journal of the American Chemical Society.

18 May 2021

Regular consumption of sardines helps prevent the onset of type 2 diabetes

The health benefits of sardines and oily fish are widely known: their high levels of unsaturated fats help to regulate cholesterol levels and prevent the onset of cardiovascular diseases. However, the benefits don't end there.

6 May 2021

Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk

Drinking two or more daily sugar-sweetened beverages in adulthood is linked to a doubling in the risk of bowel cancer before the age of 50--at least in women, finds research published online in the journal Gut.

6 May 2021

Researchers show how low-protein diet during pregnancy can cause kidney problems in babies

Besides being underweight, babies born to women whose diet lacked sufficient protein during pregnancy tend to have kidney problems resulting from alterations that occurred while their organs were forming during the embryonic stage of their development.

5 May 2021

Study investigates how Brd4 influences diet-induced obesity

A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity.

4 May 2021

Processed diets may promote diseases characterized by low-grade infection and inflammation

Processed diets, which are low in fiber, may initially reduce the incidence of foodborne infectious diseases such as E. coli infections, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation such as diabetes, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

28 Apr 2021

Insulin Resistance News and Research

Further Reading

Lowering iron content in fat cells prevented mice from gaining excess weight

Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Change in diet and circadian clock can impact healthy fat tissue, finds study

Study implicates placental protein as a possible regulator of an infant’s birthweight

Increasing a protein concentrated in brown fat may lower diabetes risk

Eating at least two servings of fruit per day reduces diabetes risk by 36%

Mice study shows life expectancy can be increased by an average of 30%

Can depression increase the likelihood of rapid kidney function decline?

Expanding genomic research into different ancestries yields more and better results

Blocking ABCB10 protein in liver cells protects against high blood sugar, fatty liver disease

Researchers report promising biotherapeutics for obesity and related medical complications

Regular consumption of sardines helps prevent the onset of type 2 diabetes

Daily intake of two or more sugar-sweetened drinks associated with higher bowel cancer risk

Researchers show how low-protein diet during pregnancy can cause kidney problems in babies

Study investigates how Brd4 influences diet-induced obesity

Processed diets may promote diseases characterized by low-grade infection and inflammation

Clinical trial examines metabolic effects of natural compound NMN in people

CU researcher receives NIH grant to analyze the link between gut microbiome and osteoarthritis

Study identifies differences in biomarkers of inflammation between novel diabetes subgroups

Diet and lifestyle may play a significant role in Alzheimer's disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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