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Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

In a recent bioRxiv preprint research paper, Botond Z. Igyártó and colleagues from Thomas Jefferson University demonstrated the inflammatory nature of the lipid nanoparticles (LNPs).

15 Mar 2021

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

In a methodologically trailblazing paper published in the journal Nature Genetics, a team of Belgian scientists uncovered an assembly of coronavirus host factors that may be exploited to develop drugs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also potentially forthcoming zoonotic coronaviruses.

14 Mar 2021

Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

A new preprint research paper, posted to the bioRxiv* server, uncovered more information on the different structural conformations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress.

11 Mar 2021

Study reveals how lung alveolus forms at cellular level

Researchers from Children's Hospital of Philadelphia have determined what happens at a cellular level as the lung alveolus forms and allows newborns to breathe air.

11 Mar 2021

NIAID awards $2.5 million in grants to support research on bacteriophage therapy

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded $2.5 million in grants to 12 institutes around the world to support research on bacteriophage therapy.

11 Mar 2021

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease.

11 Mar 2021

SARS-CoV-2 spike S1 subunit induces hypercoagulability

The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.

10 Mar 2021

Study opens the door to new possibilities targeting telomeres to help treat cancer

The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre continues to make progress in unraveling the role that telomeres -the ends of chromosomes that are responsible for cellular aging as they shorten- play in cancer.

10 Mar 2021

Scientists optimize wastewater disinfection process to minimize spread of antibiotic resistance

Antibiotic-resistant bacteria have become a global threat today, owing in part to the efficiency with which resistance spreads among them. Some of this spread happens in waterbodies—and our wastewater systems are no exception.

8 Mar 2021

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP—the standard treatment regimen.

8 Mar 2021

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria.

5 Mar 2021

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

A new study by researchers at the University of California, San Francisco, discusses the different aspects of long-term immune responses in a wide sample of patients, as well as how they vary in clinical severity and sequelae.

3 Mar 2021

Researchers discover new ingredient that has protective effects against Parkinson’s disease

Sesame seed oil, used by many for its nutty aroma and high burn-point, is made by extracting the fatty oils from sesame seeds, with the empty shells thrown out as waste. In a literal instantiation of the age-old adage "one man's trash is another man's treasure", researchers discovered that a chemical called sesaminol, abundant in this waste, has protective effects against Parkinson's disease.

2 Mar 2021

Study reveals presence of glial plasticity, offers future therapeutic strategy for epilepsy

Tohoku University scientists and their colleagues in Germany have revealed that a first-time exposure to only a brief period of brain hyperactivity resulted in an acute breakdown of the inter-cellular network of glial cells.

2 Mar 2021

Protein kinase inhibitors could help treat immunodeficiency in HIV patients

HIV infections are treated with antiviral drugs which effectively prevent the disease from developing. While pharmacological HIV therapy has advanced considerably, the virus cannot be entirely eliminated from the body with currently available drugs.

1 Mar 2021

New paper discusses how smoking may affect risk for COVID-19

A new paper published online in the Annals of the American Thoracic Society discusses how smoking may affect risk for COVID-19 and the types of research that are needed to better understand the link between smoking and COVID-19 risk.

1 Mar 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

Researchers use Doppler to look inside living cells, track their metabolic activity

Doppler radar improves lives by peeking inside air masses to predict the weather. A Purdue University team is using similar technology to look inside living cells, introducing a method to detect pathogens and treat infections in ways that scientists never have before.

26 Feb 2021

'Miracle poison' can target a variety of different proteins

Researchers prove they can engineer proteins called proteases to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuro-regeneration to cytokine storm.

25 Feb 2021

Artificial control of the glial state could help improve memory function

Tohoku University scientists have shown that neuronal and glial circuits form a loosely coupled super-network within the brain.

25 Feb 2021

Intracellular News and Research

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

Study reveals how lung alveolus forms at cellular level

NIAID awards $2.5 million in grants to support research on bacteriophage therapy

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

SARS-CoV-2 spike S1 subunit induces hypercoagulability

Study opens the door to new possibilities targeting telomeres to help treat cancer

Scientists optimize wastewater disinfection process to minimize spread of antibiotic resistance

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

Researchers discover new ingredient that has protective effects against Parkinson’s disease

Study reveals presence of glial plasticity, offers future therapeutic strategy for epilepsy

Protein kinase inhibitors could help treat immunodeficiency in HIV patients

New paper discusses how smoking may affect risk for COVID-19

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

Researchers use Doppler to look inside living cells, track their metabolic activity

'Miracle poison' can target a variety of different proteins

Artificial control of the glial state could help improve memory function

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