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Tetanus booster shot enhances effect of vaccine therapy for lethal brain tumors

An innovative approach using a tetanus booster to prime the immune system enhances the effect of a vaccine therapy for lethal brain tumors, dramatically improving patient survival, according to a study led by Duke Cancer Institute researchers.

12 Mar 2015

Recruitment completed for Phase III PROUD-PV trial of P1101 for treatment of polycythemia vera

PharmaEssentia (Taipei, Taiwan) and AOP Orphan (Vienna, Austria) announce the completion of recruitment for the Phase III trial PROUD-PV to support global marketing of P1101 (Ropeginterferon alfa-2b), a novel, long-acting, mono-pegylated interferon for the first line treatment of polycythemia vera.

11 Mar 2015

Andor Neo sCMOS camera is perfect partner for correlative microscopy

CD44 is recognised as an important cell surface receptor involved in the adhesion of circulating leukocytes to endothelium, a process that is critical for their trafficking in the vasculature. Now, a Japanese group of researchers using an ultra-sensitive Andor Neo sCMOS camera in their correlative microscopy set-up has demonstrated that microvilli projections around the cell surface mediate this adhesion.

From Andor Technology Ltd. 11 Mar 2015

Imperial scientists develop new test that uses human stem cells to predict side effects of drugs

Scientists at Imperial College London have developed a test that uses combinations of cells from a single donor's blood to predict whether a new drug will cause a severe immune reaction in humans.

10 Mar 2015

Scientists find blood-based genomic biomarkers that could help identify young boys with ASD

In a study published in the current online issue of JAMA Psychiatry, an international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report finding a highly accurate blood-based measure that could lead to development of a clinical test for autism spectrum disorder (ASD) risk in males as young as one to two years old.

10 Mar 2015

M-MDSCs may be effective in treating arthritis in humans

Using a mouse model of rheumatoid arthritis, scientists have discovered that a form of cellular immunotherapy by intravenous administration of monocytic myeloid-derived suppressor cells, or M-MDSCs, might be an effective treatment for the disease in humans.

9 Mar 2015

Scientists design a promising vaccine for herpes viruses

Herpes simplex virus infections are an enormous global health problem and there is currently no viable vaccine.

9 Mar 2015

Salt may help control infection

Researchers at Vanderbilt University and in Germany have found that sodium - salt - accumulates in the skin and tissue in humans and mice to help control infection.

4 Mar 2015

UCLA life scientists develop new method to find genetic markers for many diseases

UCLA life scientists have created an accurate new method to identify genetic markers for many diseases -- a significant step toward a new era of personalized medicine, tailored to each person's DNA and RNA.

4 Mar 2015

Swiss teenager with classic sudden symptoms of stroke diagnosed with Lyme disease

A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease.

3 Mar 2015

CEGIR launches patient contact registry for people with eosinophilic gastrointestinal diseases

To coincide with Rare Disease Day 2015, the Consortium of Eosinophilic Gastrointestinal Disease Researchers today launched a patient contact registry for individuals with eosinophilic gastrointestinal diseases (EGID), a group of rare diseases.

28 Feb 2015

Pediatric patients who receive quick antibiotics for fever, neutropenia have reduced PICU needs

A University of Colorado Cancer Center study published in the journal Pediatric Blood & Cancer shows that pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and showing neutropenia (low neutrophil count), go on to have decreased intensive care consultation rate and lower mortality compared with patients who receive antibiotics outside the 60-minute window.

27 Feb 2015

Study focuses on improving therapeutic outcomes in cancer patients through diet-drug combination

Boosting anti-cancer immunity through diet and novel drug therapies—that's the idea behind a collaborative project involving researchers from the South Dakota State University College of Pharmacy and Sanford Research in Sioux Falls.

27 Feb 2015

Reslizumab drug appears to reduce risk of severe asthma attacks

An investigational drug appears to cut the risk of severe asthma attacks in half for patients who have difficulty controlling the disorder with standard medications, according to results from two multicenter clinical trials.

25 Feb 2015

Case Western dental researcher discovers new way to model how T cells cause inflammation in mice

Case Western Reserve University dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice.

23 Feb 2015

Palbociclib extends progression-free survival in advanced breast cancer patients

Palbociclib, an investigational oral medication that works by blocking molecules responsible for cancer cell growth, is well tolerated and extends progression-free survival (PFS) in newly diagnosed, advanced breast cancer patients, including those whose disease has stopped responding to traditional endocrine treatments.

21 Feb 2015

Epigenome-wide association study helps discover genes linked to allergies and asthma

Researchers from Canada, the UK, Sweden and the US have discovered more than 30 genes that strongly affect an antibody involved in allergies and asthma. Some of the genes could provide targets for drugs to treat those conditions, according to the international team's study, published online in Nature on Feb. 18.

20 Feb 2015

Two diagnostic tests can help identify children who require surgical treatment for appendicitis

Data from two standard diagnostic tests commonly obtained in children evaluated for abdominal pain--when combined--can improve the ability of emergency department physicians and pediatric surgeons to identify those patients who should be sent to the operating room for prompt removal of an inflamed appendix; those who may be admitted for observation; and those who may safely be discharged home, according to a new study published online as an "article in press" in the Journal of the American College of Surgeons.

20 Feb 2015

New study turns to epigenetics to look for new therapeutic targets to treat allergic diseases

Scientists have discovered over 30 new genes that predispose people to allergies and asthma, some of which could be targets for new drugs.

20 Feb 2015

Natalizumab drug helps scientists confirm how 'viral reservoirs' form in HIV patients

A drug used to treat patients with Crohn's disease and multiple sclerosis has helped scientists confirm how "viral reservoirs" form in patients living with HIV and also proven effective in animal trials at blocking the pathways to those reservoirs in the brain and gut, a team of researchers reported recently in the journal PLOS Pathogens.

19 Feb 2015

Leukocyte News and Research

Tetanus booster shot enhances effect of vaccine therapy for lethal brain tumors

Recruitment completed for Phase III PROUD-PV trial of P1101 for treatment of polycythemia vera

Andor Neo sCMOS camera is perfect partner for correlative microscopy

Imperial scientists develop new test that uses human stem cells to predict side effects of drugs

Scientists find blood-based genomic biomarkers that could help identify young boys with ASD

M-MDSCs may be effective in treating arthritis in humans

Scientists design a promising vaccine for herpes viruses

Salt may help control infection

UCLA life scientists develop new method to find genetic markers for many diseases

Swiss teenager with classic sudden symptoms of stroke diagnosed with Lyme disease

CEGIR launches patient contact registry for people with eosinophilic gastrointestinal diseases

Pediatric patients who receive quick antibiotics for fever, neutropenia have reduced PICU needs

Study focuses on improving therapeutic outcomes in cancer patients through diet-drug combination

Reslizumab drug appears to reduce risk of severe asthma attacks

Case Western dental researcher discovers new way to model how T cells cause inflammation in mice

Palbociclib extends progression-free survival in advanced breast cancer patients

Epigenome-wide association study helps discover genes linked to allergies and asthma

Two diagnostic tests can help identify children who require surgical treatment for appendicitis

New study turns to epigenetics to look for new therapeutic targets to treat allergic diseases

Natalizumab drug helps scientists confirm how 'viral reservoirs' form in HIV patients

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