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Piracetam - an unapproved drug, found in brain supplements

The market is flooded by supplements that claim to boost brain power and stave off dementia. Some of these supplements may not be harmless finds a study. These supplements have been found to contain high portions of an unapproved drug called Piracetam. The study titled, “Presence of Piracetam in Cognitive Enhancement Dietary Supplements,” was published this week in the JAMA Internal Medicine.

26 Nov 2019

Researchers find new way to protect against disease in MS model

Researchers have found a new and unexpected way of preventing disease in a preclinical model of multiple sclerosis (MS).

26 Nov 2019

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Novoheart, a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.

26 Nov 2019

Virtual reality clinic could make it easier for stroke survivors to attend therapy sessions

Researchers have created a virtual reality clinic to make it easier for stroke survivors to attend their physical and occupational therapy sessions.

22 Nov 2019

Combination therapy improves survival in patients with hepatocellular carcinoma

Combination therapy with the PD-L1 inhibitor atezolizumab and the VEGF inhibitor bevacizumab significantly improves overall survival and progression-free survival in patients with unresectable hepatocellular carcinoma compared to standard of care, showed results from a phase 3 study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

New targeted treatment for insomnia has fewer side effects

Insomnia is one of the most common sleep disorders, and is most commonly treated with hypnotics. However, hypnotics have motor and cognitive side effects.

22 Nov 2019

Software tool can predict how drugs can be combined to create effective treatments

With a shortage of new tuberculosis drugs in the pipeline, a software tool from the University of Michigan can predict how current drugs--including unlikely candidates--can be combined in new ways to create more effective treatments.

22 Nov 2019

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free -- meaning no microbes colonizing their lungs.

21 Nov 2019

UTSA research aims to use sulfur to expedite new drug development

Organosulfur compounds are widely present in our bodies and the natural environment. They are found in onions, shallots and even cauliflower. Medical research finds that when consumed, they can protect against cancer, heart disease and even diabetes. There is also evidence of these compounds' antiviral and antibacterial uses. About a quarter of all pharmaceutical drugs currently use OSCs.

21 Nov 2019

Researchers turn to older treatment methods for new health challenges

The last thing anyone wants during a stay in the hospital is a hospital-acquired infection. Nosocomial infections, as they are called, are on the rise as more pathogens become resistant to drugs currently available.

21 Nov 2019

Sphingolipids associated with heart disease in African Americans with lupus

When it comes to cholesterol, we've come to accept a simple narrative. Our risk of heart disease is lower when we have more "good cholesterol," or high-density lipoproteins (HDL), and less "bad cholesterol," or low-density lipoproteins (LDL) and triglycerides.

21 Nov 2019

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

BrainStorm Cell Therapeutics Inc., a leader in the development of innovative autologous cellular therapies for highly debilitating neurodegenerative diseases, today announced publication of "NurOwn Phase 2 Randomized Clinical Trial in ALS: Safety, Clinical and BioMarker Results," in the international, peer-reviewed journal Neurology.

20 Nov 2019

ETVAX vaccine candidate shows promise against enterotoxigenic E. coli diarrhea

University of Gothenburg reports first successful results of the oral, inactivated vaccine candidate ETVAX against enterotoxigenic E. coli diarrhea in a placebo-controlled phase I/II study in infants and children from 6 months to 5 years of age in Bangladesh.

20 Nov 2019

Vaccination against HIV can be counterproductive if it triggers the wrong type of immune response

A discovery could help immunologists design vaccines that are more effective in protecting against HIV infection.

20 Nov 2019

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

Subpopulations of tumor cells may exhibit diverging behaviors from the bulk tumor due to an alternate stress response that diverts tumor cells from apoptotic death.

20 Nov 2019

New drug 'ubrogepant' may work for migraine

A new study published in the November 19, 2019 issue of JAMA shows that a newly developed small molecule drug called ubrogepant may successfully fight migraine at doses of 25 and 50 mg, with pain relief at 2 hours with both doses, while the most troublesome symptom of migraine was held off at 2 hours post-dose with the 50 mg dose. This may help millions of migraine patients to achieve pain relief and function better.

19 Nov 2019

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria.

19 Nov 2019

Mayo Clinic, Hitachi to build North America's first carbon ion treatment facility

Mayo Clinic and Hitachi, Ltd. have reached an agreement in principle to build a carbon ion treatment facility as part of Mayo Clinic's recently announced integrated oncology facility which will be constructed at Mayo Clinic's campus in Jacksonville, Florida.

19 Nov 2019

Certain traditional soup broths possess antimalarial properties

Researchers have found that some soups have antimalarial properties and can interrupt the life cycle of a malarial parasite.

19 Nov 2019

Efficacy News and Research

Piracetam - an unapproved drug, found in brain supplements

Researchers find new way to protect against disease in MS model

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Virtual reality clinic could make it easier for stroke survivors to attend therapy sessions

Combination therapy improves survival in patients with hepatocellular carcinoma

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

New targeted treatment for insomnia has fewer side effects

Software tool can predict how drugs can be combined to create effective treatments

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

UTSA research aims to use sulfur to expedite new drug development

Researchers turn to older treatment methods for new health challenges

Sphingolipids associated with heart disease in African Americans with lupus

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

ETVAX vaccine candidate shows promise against enterotoxigenic E. coli diarrhea

Vaccination against HIV can be counterproductive if it triggers the wrong type of immune response

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

New drug 'ubrogepant' may work for migraine

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

Mayo Clinic, Hitachi to build North America's first carbon ion treatment facility

Certain traditional soup broths possess antimalarial properties

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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