Efficacy News and Research

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Opioids do not improve quality of life or depression in OA patients

New research presented at the 2019 ACR/ARP Annual Meeting suggests that opioids contribute no measurable benefit to quality of life or depression for patients with osteoarthritis (OA).

11 Nov 2019

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis.

11 Nov 2019

Tocilizumab more effective than rituximab in achieving low disease activity in RA patients

New research discovered that tocilizumab is more effective than rituximab in achieving low disease activity in patients with rheumatoid arthritis whose synovial tissue show a low level of B cell infiltration and did not respond to conventional synthetic disease-modifying anti-rheumatic drugs (conventional synthetic DMARDs) or tumor necrosis factor inhibitors first.

11 Nov 2019

Weight-loss surgeries can lead to better diabetes control in older adults

While weight-loss surgeries are not usually performed in people above the age of 65, a new study shows that these procedures can lead to successful weight loss and better diabetes control in older adults.

10 Nov 2019

Biologics can be used effectively for both elderly-onset and young-onset RA patients

According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, both patients with rheumatoid arthritis whose disease onset occurred at an older age and those whose disease onset occurred earlier in life have similar improvements in clinical disease at 48 weeks after starting biologic disease-modifying antirheumatic drugs, as well as similar drug maintenance and adverse events discontinuation rates.

10 Nov 2019

Dengue vaccine from Takeda shows promise

Officials have confirmed the initial success with trials of Dengue vaccine. Dengue, a viral disease borne by mosquitoes is considered to be one of the top ten health threats says the world Health Organization (WHO). Since the beginning of the outbreaks and the hundreds of deaths due to this infection, researchers have been on the lookout for vaccines to prevent this infection.

10 Nov 2019

Additional medications needed to control the symptoms of juvenile idiopathic arthritis

According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, there is a profound ongoing need for additional medications to control the signs and symptoms of juvenile idiopathic arthritis, despite the availability of several approved biologic disease-modifying antirheumatic drugs (biologics).

10 Nov 2019

Glutamine-blocking compound slows cancer growth, unleashes anti-tumor immune response

A compound developed by Johns Hopkins researchers that blocks glutamine metabolism can slow tumor growth, alter the tumor microenvironment and promote the production of durable and highly active anti-tumor T cells.

10 Nov 2019

Study reveals safety, efficacy of live zoster vaccine for people taking TNF inhibitors

According to new research findings presented this week at the 2019 ACR/ARP Annual Meeting, the live zoster virus vaccine is safe for people who are currently receiving tumor necrosis factor inhibitor (TNFi) biologic therapies for various indications.

10 Nov 2019

Researchers determine ways to assess social communication difficulties in children with TBI

Kessler Foundation researchers conducted a pilot study to determine ways to assess social communication difficulties in children with impaired social functioning caused by moderate-to-severe traumatic brain injury.

8 Nov 2019

Genetic diversity impacts efficacy of cancer immunotherapy

The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution.

8 Nov 2019

Game-changing diagnostic test for prion diseases

Researchers have developed an effective way of testing for prion diseases, a group of fatal neurodegenerative illnesses caused by abnormally folded proteins.

8 Nov 2019

UK military researcher studies ways to prevent chronic pain

Josh Van Wyngaarden grew up in a military family, traveling all over the world during his father's 22 years in the Air Force.

7 Nov 2019

HIV-1 virus characteristics can predict treatment efficacy with specific antibody treatment

Current HIV-1 therapies have been proven to be highly effective in slowing the progression of the virus in the body with only minimal side effects.

6 Nov 2019

Cannabis could help in PTSD

A new study from Canada, published in the Journal of Psychopharmacology, suggests that many people with PTSD may be getting help with their condition from the use of cannabis. For the first time ever, this research documents how cannabis use is related both to PTSD and to mental health outcomes in the general population.

6 Nov 2019

Nanotechnologies can lead to big advances in cancer therapy

Nami Therapeutics Corporation, which gets its name from the Mandarin word for "nano," is committed to using nanotechnologies to make big advances in cancer therapy.

6 Nov 2019

AnaBios receives IDIQ contract to assess drug safety related to cardiac function

The U.S. Food and Drug Administration (FDA) has awarded AnaBios an exclusive Indefinite Delivery Indefinite Quantity (IDIQ) contract to employ adult human primary tissues and cardiomyocytes from organ donors to assess drug safety related to cardiac function.

6 Nov 2019

Pioneering brain chip to fight opioid addiction: first US clinical test

Opioid addiction is among the biggest medical conditions troubling the U.S. today, and is far from reaching a solution. In 2017, it claimed almost 50 deaths per 100,000 in the state of West Virginia – the highest drug-overdose-related death rate in the US. Today, however, there is a gleam of hope from a new trial of an old technology to help fight this battle – a brain-embedded chip to counter opioid-induced cravings in treatment-refractory patients.

6 Nov 2019

Chiral interactions could be leveraged to improve the performance of drug-delivery nanoparticles

MIT engineers have shown that they can enhance the performance of drug-delivery nanoparticles by controlling a trait of chemical structures known as chirality -- the "handedness" of the structure.

6 Nov 2019

Penn researchers tag CAR T cells with imaging markers to monitor cancer therapy

With CAR T cell therapy, a patient's own immune cells are genetically modified and inserted back into the body to find and kill cancer. This form of immunotherapy has already revolutionized some cancer treatments, but once the CAR T cells are inside a patient, where do they go? How do doctors know that they have successfully reached their target and that they are continuing to fight disease weeks, months, or even years later?

5 Nov 2019

Efficacy News and Research

Opioids do not improve quality of life or depression in OA patients

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Tocilizumab more effective than rituximab in achieving low disease activity in RA patients

Weight-loss surgeries can lead to better diabetes control in older adults

Biologics can be used effectively for both elderly-onset and young-onset RA patients

Dengue vaccine from Takeda shows promise

Additional medications needed to control the symptoms of juvenile idiopathic arthritis

Glutamine-blocking compound slows cancer growth, unleashes anti-tumor immune response

Study reveals safety, efficacy of live zoster vaccine for people taking TNF inhibitors

Researchers determine ways to assess social communication difficulties in children with TBI

Genetic diversity impacts efficacy of cancer immunotherapy

Game-changing diagnostic test for prion diseases

UK military researcher studies ways to prevent chronic pain

HIV-1 virus characteristics can predict treatment efficacy with specific antibody treatment

Cannabis could help in PTSD

Nanotechnologies can lead to big advances in cancer therapy

AnaBios receives IDIQ contract to assess drug safety related to cardiac function

Pioneering brain chip to fight opioid addiction: first US clinical test

Chiral interactions could be leveraged to improve the performance of drug-delivery nanoparticles

Penn researchers tag CAR T cells with imaging markers to monitor cancer therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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