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Phase II trial results of OHR/AVR118 in patients with cancer cachexia announced

Ohr Pharmaceutical, a pharmaceutical company focused on the development of novel therapeutics for large unmet medical needs, today announced the results of a Phase II trial to evaluate the effects of OHR/AVR118 in advanced cancer patients with cachexia. Cancer cachexia is the complex, multi-symptom syndrome seen in late-stage cancer patients, characterized by anorexia and unintended loss of appetite, progressive and continual weight loss, accompanied by generalized host tissue wasting, skeletal muscle atrophy, immune and metabolic dysfunction, and a greatly diminished quality of life.

21 Mar 2013

Investigators examine effectiveness of probiotics for cancer treatment

One may not think of probiotics -- like those found in yogurt that promote good digestive health -- as a weapon used in the fight against cancer. But that is the focus of investigators at The Cancer Institute of New Jersey, who are examining the effectiveness of probiotics as they relate to the outcomes of bone marrow transplant for patients with blood cancers.

21 Mar 2013

New research provides better understanding of preserving brain's functions while killing cancer

New research from Wake Forest Baptist Medical Center is giving radiation oncologists who treat brain tumors a better understanding of how to preserve the brain's functions while still killing cancer.

21 Mar 2013

Cedars-Sinai surgeons perform more adult heart transplants in 2012, statistics show

For the third year in a row, the Cedars-Sinai Heart Institute and Comprehensive Transplant Center performed more adult heart transplants than any other U.S. medical center, according to statistics compiled by the United Network for Organ Sharing, the nonprofit organization that manages the nation's transplant system.

21 Mar 2013

New biodegradable nanoparticles deliver inflammation-resolving drugs to sites of tissue injury

A multicenter team of researchers, including scientists at Columbia University Medical Center (CUMC), Brigham and Women's Hospital (BWH), Mount Sinai School of Medicine, and Massachusetts Institute of Technology, has developed biodegradable nanoparticles that are capable of delivering inflammation-resolving drugs to sites of tissue injury.

20 Mar 2013

Hepatitis C and HIV co-infection treatment: an interview with Prof Boecher, Boehringer Ingelheim

Chronic hepatitis C infection is one of the most frequent chronic infectious diseases worldwide. The WHO estimates that 150 million people worldwide are chronically infected with the hepatitis C virus (HCV).

20 Mar 2013

Prevalence of acute hepatitis C virus infection is nearly 1% among newly incarcerated inmates

study published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, estimates that the prevalence of acute hepatitis C virus (HCV) infection is nearly one percent among newly incarcerated inmates with a history of recent drug use.

20 Mar 2013

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Researchers at the University of Maryland School of Medicine have identified a peptide, or protein, derived from Pacific cod that may inhibit prostate cancer and possibly other cancers from spreading, according to preclinical research published online in the Proceedings of the National Academy of Sciences.

20 Mar 2013

HCV screening of IV drug users new to the prison system could identify thousands of new HCV cases annually

A study published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, estimates that the prevalence of acute hepatitis C virus (HCV) infection is nearly one percent among newly incarcerated inmates with a history of recent drug use. Findings suggest that systematic screening of intravenous (IV) drug users who are new to the prison system could identify more than 7,000 cases of HCV across the U.S. annually—even among asymptomatic inmates.

19 Mar 2013

Hepatitis C virus rarely transmitted through sex between monogamous heterosexuals

Individuals infected by the hepatitis C virus (HCV) have nothing to fear from sex in a monogamous, heterosexual relationship. Transmission of HCV from an infected partner during sex is rare according to new research published in the March issue of Hepatology, a journal published by Wiley on behalf of the American Association for the Study of Liver Diseases (AASLD).

19 Mar 2013

Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Alnylam Pharmaceuticals a leading RNAi therapeutics company, announced today that it has initiated dosing in its Phase I clinical trial with ALN-TTRsc, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR).

19 Mar 2013

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research led by Duke Cancer Institute.

19 Mar 2013

New study may help develop targeted therapies for controlling tissue destruction

Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger inflammation, which in turn can cause more cellular necrosis.

19 Mar 2013

Harvard’s Wyss Institute to harness Sony DADC's expertise to advance Organs-on-Chips technologies

Today the Wyss Institute for Biologically Inspired Engineering at Harvard University and Sony DADC announced a collaboration that will harness Sony DADC's global manufacturing expertise to further advance the Institute's Organs-on-Chips technologies.

18 Mar 2013

Researchers find white blood cells produce and eliminate RBCs

Researchers at Albert Einstein College of Medicine of Yeshiva University and the Icahn School of Medicine at Mount Sinai have found that macrophages - white blood cells that play a key role in the immune response - also help to both produce and eliminate the body's red blood cells (RBCs).

18 Mar 2013

Research: Decreased levels of vitamin D may influence smokers to develop tobacco-related cancer

New research appearing online today in Clinical Chemistry, the journal of AACC, shows that decreased levels of vitamin D may predispose smokers to developing tobacco-related cancer.

16 Mar 2013

Weekend reading: Humanizing hospitals, splurge of health data and huge sodas

Every week reporter Ankita Rao selects interesting reading from around the Web.

15 Mar 2013

Study shows how oils and fats regulate feeling of satiety

Work groups at Technische Universit-t M-nchen under Prof. Peter Schieberle and at the University of Vienna under Prof. Veronika Somoza studied four different edible fats and oils: Lard, butterfat, rapeseed oil and olive oil.

15 Mar 2013

EASL urges UK to press ahead with proposed implementation of minimum unit pricing of alcohol

According to WHO, liver cirrhosis accounts for 1.8% (i.e. 170,000) of all deaths in Europe. In recent years liver cirrhosis has become a serious health threat in some Western European countries such as Ireland and the United Kingdom, where over the last 10 years the associated mortality has increased.

15 Mar 2013

Cardiohelp assists heart by pumping blood to oxygenator in seriously ill patients

A viral infection was causing life-threatening heart failure in Loyola University Medical Center patient Michelle Rivera.

14 Mar 2013

Liver News and Research

Phase II trial results of OHR/AVR118 in patients with cancer cachexia announced

Investigators examine effectiveness of probiotics for cancer treatment

New research provides better understanding of preserving brain's functions while killing cancer

Cedars-Sinai surgeons perform more adult heart transplants in 2012, statistics show

New biodegradable nanoparticles deliver inflammation-resolving drugs to sites of tissue injury

Hepatitis C and HIV co-infection treatment: an interview with Prof Boecher, Boehringer Ingelheim

Prevalence of acute hepatitis C virus infection is nearly 1% among newly incarcerated inmates

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

HCV screening of IV drug users new to the prison system could identify thousands of new HCV cases annually

Hepatitis C virus rarely transmitted through sex between monogamous heterosexuals

Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

New study may help develop targeted therapies for controlling tissue destruction

Harvard’s Wyss Institute to harness Sony DADC's expertise to advance Organs-on-Chips technologies

Researchers find white blood cells produce and eliminate RBCs

Research: Decreased levels of vitamin D may influence smokers to develop tobacco-related cancer

Weekend reading: Humanizing hospitals, splurge of health data and huge sodas

Study shows how oils and fats regulate feeling of satiety

EASL urges UK to press ahead with proposed implementation of minimum unit pricing of alcohol

Cardiohelp assists heart by pumping blood to oxygenator in seriously ill patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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