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Modified natural killer cells may be new player in CAR-T immunotherapies

Emerging CAR-T immunotherapies leverage modified versions of patient's T-cells to target and kill cancer cells.

29 Jun 2018

URI researchers working to develop novel medication to treat alcohol use disorder

Alcohol abuse is among the leading causes of preventable death in the United States, killing more than 88,000 people a year, according to the Centers for Disease Control.

28 Jun 2018

Researchers reveal complexity of NMDA receptor drug discovery target

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression.

28 Jun 2018

A small molecule can inhibit chemotherapy resistance of certain tumors

A team of researchers from the CNRS and Université Nice Sophia Antipolis has just shown that a small molecule called methiothepin can inhibit the chemotherapy resistance of certain tumors.

28 Jun 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

Study describes new mechanism involved in memory loss associated with aging

A study led by Luísa Lopes, Group Leader at Instituto de Medicina Molecular João Lobo Antunes and published today in the prestigious journal Molecular Psychiatry, describes a new mechanism involved in memory loss associated with aging.

28 Jun 2018

UT Southwestern study reveals structural information for major brain receptor

UT Southwestern researchers today published the first atomic structure of a brain receptor bound to a drug used to reverse anesthesia and to treat sedative overdoses.

28 Jun 2018

New conference to establish roadmap for treatment-focused research on smell and taste disorders

The Monell Center, in partnership with the University of Florida Center for Smell and Taste and the Rocky Mountain Taste and Smell Center at the University of Colorado School of Medicine, will host an interdisciplinary two-day conference in November 2018 to establish a roadmap for treatment-focused research on smell and taste disorders.

27 Jun 2018

Study provides insight into development of autism in the human brain

In a study published in Stem Cell Reports, a McGill team of scientists led by Dr. Carl Ernst, researcher at the Douglas Hospital Research Centre, revealed a molecular mechanism that may play a role in the development of autism.

27 Jun 2018

New study finds way to help treat alcohol addiction and ease withdrawal symptoms

According to a new study by Scripps Research scientists, activating a receptor found in brain cells may help treat alcohol addiction and ease some withdrawal symptoms. The researchers studied the effects of activating the receptor in alcohol-addicted rats and reported the results today in the journal eNeuro.

27 Jun 2018

Research provides new target to help treat chemotherapy-induced diarrhea

Some 50 to 80 percent of cancer patients taking powerful chemotherapy drugs develop diarrhea, which can be severe and in some cases life-threatening.

27 Jun 2018

Study shows benefits, safety of long-lasting radionuclide therapy for patients with advanced NETs

A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Microbiologists and plant scientists pinpoint genetic weakness in cholera pandemic's armor

While cholera rages across many regions of the world, a team of microbiologists and plant scientists has pinpointed a genetic weakness in the pandemic's armor, which could lead to future treatments.

26 Jun 2018

Study suggests new approach for treating alcohol use disorder

Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. The study, published in eNeuro, suggests a new approach towards the treatment of alcohol use disorder.

26 Jun 2018

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

25 Jun 2018

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

AbbVie , a research-based global biopharmaceutical company, and Calibr, a nonprofit drug discovery division of Scripps Research, today announced a collaboration to develop T-cell therapies aimed primarily at cancer, including solid tumors.

25 Jun 2018

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for standard review a new supplemental Biologics License Application for KEYTRUDA, Merck's anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with resected, high-risk stage III melanoma and granted a Prescription Drug User Fee Act, or target action, date of February 16, 2019.

25 Jun 2018

Researchers use gene editing to reduce autism symptoms in mice

Researchers have used CRISPR-Cas9 gene editing to treat symptoms of autism in mice. It is hoped that the tool could one day be used to help humans.

25 Jun 2018

Higher BMI at younger age linked to reduced premenopausal breast cancer risk

Having a higher body mass index at a younger age is associated with a decreased risk of developing breast cancer before the menopause, major new research funded by Breast Cancer Now and other collaborators has found.

25 Jun 2018