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Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

Oestrogen may be linked to a woman’s risk of developing dementia

A new study examines the risk of dementia with reproductive factors in women.

10 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

MOFs could help improve the delivery of genetic cargo into target cells

Hybrid material helps ferry genetic cargo to target cells. An emerging type of material called a metal-organic framework(MOF) could help improve the delivery of genetic material for treating disease.

10 Apr 2022

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a two-year overall survival rate of 32.5 percent, according to data from the CodeBreaK 100 clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

A new chimeric antigen receptor (CAR) T-cell product had an acceptable safety profile and showed early signs of efficacy as a monotherapy and in combination with an mRNA vaccine in patients with solid tumors, according to preliminary data from a phase I/II clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Novel therapy advances to clinical trial for the treatment of glioblastoma

A novel therapy studied at the Medical College of Wisconsin (MCW) Cancer Center has led to a clinical trial for the treatment of glioblastoma, a rare and aggressive form of brain cancer, yet the most common primary brain tumor in adults.

10 Apr 2022

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Patients with advanced melanoma whose cancer does not respond to treatment with widely used immunotherapy drugs known as PD-1 inhibitors are often switched to treatment with a second type of immunotherapy drug – a CTLA-4 inhibitor such as the drug ipilimumab.

8 Apr 2022

City of Hope's late-breaking clinical trial data to be presented at AACR

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, will present late-breaking and clinical trial findings at this year's American Association for Cancer Research Annual Meeting, which begins today.

8 Apr 2022

Artificial intelligence model could predict side effects resulting from new combination therapies

Preliminary data from an artificial intelligence model could potentially predict side effects resulting from new combination therapies, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

8 Apr 2022

Depressive disorders are associated with general increase in the deformability of immune cells

A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.

8 Apr 2022

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

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8 Apr 2022

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

Researchers described a case of co-infection with SARS-CoV-2 variants of concern, Delta and Omicron.

8 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

NHLBI researchers support multiple programs to address pregnancy-related health disparities

During Black Maternal Health Week, April 11-17, and in preparation for Women's Health Month in May, researchers are raising awareness about pregnancy-related complications that disproportionately affect Black people.

7 Apr 2022

UC researcher awarded renewal grant to continue the study of genetic drivers of breast cancer

A grant renewal for a University of Cincinnati researcher will help continue the study of genetic drivers of breast cancer and potential therapeutic targets.

7 Apr 2022

Smoking cessation could help heart disease patients gain five years of healthy life

Smoking cessation adds the same number of heart disease-free years to life as three preventive medications combined, according to research presented at ESC Preventive Cardiology 2022, a scientific congress of the European Society of Cardiology.

7 Apr 2022

New website offers accurate, reliable information about causes of cancer

A team led by the Zhu Family Center for Global Cancer Prevention at Harvard T.H. Chan School of Public Health and the Center for Cancer Equity and Engagement at the Dana-Farber/Harvard Cancer Center has launched Cancer FactFinder (https://cancerfactfinder.org/), a new website that provides accurate and reliable information about what does and does not cause cancer.

7 Apr 2022

Therapy News and Research

Immunocompromised hosts with Delta/Omicron co-infections

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Oestrogen may be linked to a woman’s risk of developing dementia

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

MOFs could help improve the delivery of genetic cargo into target cells

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

Novel therapy advances to clinical trial for the treatment of glioblastoma

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

City of Hope's late-breaking clinical trial data to be presented at AACR

Artificial intelligence model could predict side effects resulting from new combination therapies

Depressive disorders are associated with general increase in the deformability of immune cells

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

Improved seroprevalence and antibody response after third COVID-19 vaccination

NHLBI researchers support multiple programs to address pregnancy-related health disparities

UC researcher awarded renewal grant to continue the study of genetic drivers of breast cancer

Smoking cessation could help heart disease patients gain five years of healthy life

New website offers accurate, reliable information about causes of cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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