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Mathematical models can improve efficiency and quality of healthcare

Healthcare organizations face huge challenges during the upcoming years: the constant cost increases must be halted, while at the same time patients are becoming more and more demanding, and hospitals nationwide still cope with some 2000 avoidable deaths each year. Simultaneously improving efficiency and quality of care would seem to be a contradiction in terms. Yet Kortbeek shows in his thesis, along a number of case studies, that this is absolutely doable. The key is developing and applying mathematical models.

13 Dec 2012

Dantrolene may help combat Duchenne muscular dystrophy in boys

Drugs are currently being tested that show promise in treating patients with Duchenne muscular dystrophy (DMD), an inherited disease that affects about one in 3,600 boys and results in muscle degeneration and, eventually, death.

13 Dec 2012

FDA grants Orphan Drug designation to Milo Biotechnology's AAV1-FS344 inhibitor

Milo Biotechnology today announced its AAV1-FS344 has been granted Orphan Drug designation from the FDA's Office of Orphan Products Development for treatment of Becker and Duchenne muscular dystrophy. AAV1-FS344 is a gene therapy-delivered myostatin inhibitor that increases muscle strength.

12 Dec 2012

Link between CTNNA3 gene mutations and arrhythmogenic right ventricular cardiomyopathy

Unfortunately, newspaper articles about young athletes dying suddenly on the field are not unheard of. Such reports fuel discussions about compulsory screening, for example of young footballers, for heart failure. Research by scientists from Ghent (VIB/UGent) and Italy will benefit these screening methods.

12 Dec 2012

Gestational age and size at birth affect risk of early diagnosis of esophagitis

Infants that are born preterm or with impaired growth have an increased risk of developing gastroesophageal reflux disease (GERD), possibly leaving them vulnerable to the development of esophageal adenocarcinoma later in life.

12 Dec 2012

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

11 Dec 2012

Ligand commences PG-free melphalan pivotal trial in multiple myeloma

Ligand Pharmaceuticals Incorporated announced today that it has initiated a pivotal trial of Captisol-enabled, propylene glycol-free (PG-free) high-dose melphalan as a conditioning treatment prior to autologous transplant for patients with multiple myeloma.

11 Dec 2012

Almirall, Forest Laboratories' Tudorza Pressair now available in the U.S. pharmacies

Forest Laboratories, Inc. and Almirall, S.A. announced today that Tudorza Pressair (aclidinium bromide inhalation powder) 400mcg is now available in pharmacies throughout the United States.

11 Dec 2012

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

Fred Hutchinson Cancer Research Center and GlaxoSmithKline PLC (GSK) today announced a partnership to develop therapeutics to treat an inherited form of muscular dystrophy.

11 Dec 2012

Celgene announces results from REVLIMID plus VIDAZA phase II study on AML

Celgene International Sàrl today announced that results from a study evaluating the combination of REVLIMID (lenalidomide) plus VIDAZA (azacitidine) in patients 60 years or older with untreated acute myeloid leukemia (AML) were presented at the American Society of Hematology annual meeting in Atlanta, GA.

11 Dec 2012

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

10 Dec 2012

Don’t stretch yourself too much before cycling

Stretching immediately before starting cycling appears to impair exercise efficiency and durability, warn researchers.

10 Dec 2012

Simple technique based on principles of craniofacial surgery can maximize patient outcomes

As surgical teams gain experience with facial transplantation, a careful approach to planning based on the principles of craniofacial surgery can help to maximize patient outcomes in terms of facial form and function, according to an article in The Journal of Craniofacial Surgery.

10 Dec 2012

New survival results from Genentech’s Perjeta Phase III combination study on HER2-positive mBC

Genentech, a member of the Roche Group, today announced updated survival results from the Phase III CLEOPATRA study, which showed that the combination of Perjeta (pertuzumab), Herceptin (trastuzumab) and docetaxel chemotherapy significantly extended the lives (overall survival) of people with previously untreated HER2-positive metastatic breast cancer (mBC), compared to Herceptin, chemotherapy and placebo.

10 Dec 2012

Perimenopausal lifestyle modifications could reduce risk of breast cancer in obese woman

Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research.

10 Dec 2012

Maintaining weight loss may improve cardiometabolic profile in postmenopausal women

When you're postmenopausal and overweight, losing weight is a good thing, but gaining back just a few pounds may actually be detrimental to your cardiovascular health.

10 Dec 2012

LSUHSC to advance research on social, genetic, environmental and behavioral determinants of future obesity

Melinda Sothern, PhD, CEP, Professor and Director of the Behavioral and Community Health Sciences Program at LSU Health Sciences Center New Orleans School of Public Health, has been awarded $675,000 in grant funding to advance her research on the role of social, genetic, environmental and behavioral determinants of future obesity.

7 Dec 2012

Scientists identify underlying genetic cause for rare motor neurone disorder

Scientists have identified an underlying genetic cause for a rare disorder of motor neurones, and believe this may help find causes of other related diseases.

7 Dec 2012

Scientists isolate previously unknown protein in skeletal muscle

Scientists at Dana-Farber Cancer Institute have isolated a previously unknown protein in muscles that spurs their growth and increased power following resistance exercise. They suggest that artificially raising the protein's levels might someday help prevent muscle loss caused by cancer, prolonged inactivity in hospital patients, and aging.

7 Dec 2012

Bilirubin can inhibit clogging of arteries and prevent deadly consequences

Each year, about 610,000 Americans suffer their first heart attack, according to the Centers for Disease Control and Prevention. Heart attacks and other symptoms of cardiovascular disease can be caused when blockage occurs in the arteries. In a new study from the University of Missouri, a scientist has discovered a natural defense against arterial blockage: bilirubin.

6 Dec 2012

Muscle News and Research

Mathematical models can improve efficiency and quality of healthcare

Dantrolene may help combat Duchenne muscular dystrophy in boys

FDA grants Orphan Drug designation to Milo Biotechnology's AAV1-FS344 inhibitor

Link between CTNNA3 gene mutations and arrhythmogenic right ventricular cardiomyopathy

Gestational age and size at birth affect risk of early diagnosis of esophagitis

CYP2J2 implicated in preeclampsia

Ligand commences PG-free melphalan pivotal trial in multiple myeloma

Almirall, Forest Laboratories' Tudorza Pressair now available in the U.S. pharmacies

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

Celgene announces results from REVLIMID plus VIDAZA phase II study on AML

CYP2J2 implicated in preeclampsia

Don’t stretch yourself too much before cycling

Simple technique based on principles of craniofacial surgery can maximize patient outcomes

New survival results from Genentech’s Perjeta Phase III combination study on HER2-positive mBC

Perimenopausal lifestyle modifications could reduce risk of breast cancer in obese woman

Maintaining weight loss may improve cardiometabolic profile in postmenopausal women

LSUHSC to advance research on social, genetic, environmental and behavioral determinants of future obesity

Scientists identify underlying genetic cause for rare motor neurone disorder

Scientists isolate previously unknown protein in skeletal muscle

Bilirubin can inhibit clogging of arteries and prevent deadly consequences

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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