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SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes respiratory coronavirus disease 2019 (COVID-19) triggered an unprecedented public health emergency. Human mobility patterns were fundamental to the spread of SARS-CoV-2 globally. The situation is particularly acute in a country like Saudi Arabia, which has seen more than 750,000 cases and over 9,000 deaths as of March 30th, 2022.

29 Mar 2022

Immunity against SARS-CoV-2 BA.1, BA.2, and BA.3 after three doses of BNT162b2 vaccine

A new study assesses the neutralization of three Omicron sublineages by BNT162b2-vaccinated sera collected one month after the third vaccine dose. A preprint version of the study is available on the bioRxiv* server while the article undergoes peer review.

29 Mar 2022

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Furin inhibitors as potential therapeutics for treating COVID-19 and other diseases, wherein furin is integral for their pathogenicity and progression.

29 Mar 2022

New test predicts sepsis well before blood clotting and organ failure

In a potential paradigm change for sepsis diagnostics, a new test predicted sepsis soon after infection in mice - well before blood clotting and organ failure - enabling early antibiotic treatment and markedly increased survival.

29 Mar 2022

Researchers report progress en route to developing a hypoallergenic cat

Researchers at InBio (formerly Indoor Biotechnologies), a biotech company in Virginia, report progress en route to developing a hypoallergenic cat – or at least treating patients with allergies to the domestic cat – in a new article published online in The CRISPR Journal.

29 Mar 2022

$4 million program launched to find transformative therapies for ADNP syndrome

Researchers at the UC Davis MIND Institute are launching a $4 million program to find transformative therapies for ADNP syndrome. The rare genetic condition causes developmental delays and can affect the brain, heart, gastrointestinal system and more.

29 Mar 2022

Researchers discover a four-protein complex that may play key role in generating ribosomes

UT Southwestern researchers have identified a four-protein complex that appears to play a key role in generating ribosomes – organelles that serve as protein factories for cells – as well as a surprising part in neurodevelopmental disorders.

29 Mar 2022

Researchers find possible window of opportunity to target astrocyte abnormalities during ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time, impacting physical function and ultimately leading to death.

29 Mar 2022

Potential new therapeutic target for pancreatic cancer discovered

Northwestern Medicine investigators have discovered that targeting the G alpha 13 protein in pancreatic tumors promotes tumor growth and progression, according to a study published in Cell Reports.

29 Mar 2022

Common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner

Experts at Indiana University School of Medicine have helped identify that a common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner without a connection to disease.

29 Mar 2022

The different actions of CBD in SARS-CoV-2 infection

An article has described the role of cannabidiol as a potential inhibitor of hyperinflammation in SARS-CoV-2 infection.

29 Mar 2022

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

A new study assessed the molecular dynamics of potentially active natural phytochemicals to target the SARS-CoV-2 main protease.

29 Mar 2022

Viewpoint explains how T cell testing can help research on population-level SARS-CoV-2 adaptive immunity and inform public health policies

A recent viewpoint illustrated that evaluating T cell responses to COVID-19 is essential to inform public health initiatives.

29 Mar 2022

Evaluating serological responses to repeated COVID-19 vaccination in kidney transplant recipients

Researchers analyzed whether repeated vaccinations against COVID-19 increase serological response in non-responding kidney transplant recipients.

29 Mar 2022

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

In a new study, researchers tested the bi-, tri-, and tetravalent formulations of Newcastle disease virus (NDV)-based low-cost vaccine in mice.

29 Mar 2022

The relationship between circadian misalignment and the risk of COVID-19 infection

An interesting new study links changes in the daily rhythms of the human body with the risk of COVID-19.

29 Mar 2022

Algal metabolites as novel drugs against viruses

A new review article published in the Journal of Biotechnology has provided information on various nutraceutical metabolites extracted from algae.

29 Mar 2022

Is SARS-CoV-2 a Superantigen?

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), scientists have been conducting extensive studies to understand various aspects of the virus. Researchers have stated that SARS-CoV-2 manifests several biological and clinical consequences of a superantigen

29 Mar 2022

One year after severe COVID-19, T cells persist against SARS-CoV-2

In a recently published article in the journal eBioMedicine, scientists have demonstrated that critically ill coronavirus disease 2019 (COVID-19) patients are capable of generating durable memory T cell response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for more than one year after hospital discharge.

28 Mar 2022

Northwestern scientists continue to advance the understanding of COVID-19

As the COVID-19 pandemic enters its third year, Northwestern Medicine scientists continue to help advance the understanding of the disease and its impact, from investigating antibody protection against COVID-19 reinfection to elevating women in academic research and highlighting racial and ethnic disparities in COVID-19 hospital mortality in Illinois.

28 Mar 2022

Protein C News and Research

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

Immunity against SARS-CoV-2 BA.1, BA.2, and BA.3 after three doses of BNT162b2 vaccine

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

New test predicts sepsis well before blood clotting and organ failure

Researchers report progress en route to developing a hypoallergenic cat

$4 million program launched to find transformative therapies for ADNP syndrome

Researchers discover a four-protein complex that may play key role in generating ribosomes

Researchers find possible window of opportunity to target astrocyte abnormalities during ALS treatment

Potential new therapeutic target for pancreatic cancer discovered

Common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner

The different actions of CBD in SARS-CoV-2 infection

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

Viewpoint explains how T cell testing can help research on population-level SARS-CoV-2 adaptive immunity and inform public health policies

Evaluating serological responses to repeated COVID-19 vaccination in kidney transplant recipients

Newcastle disease virus-based trivalent vaccine found to be effective across SARS-CoV-2 variants in mice

The relationship between circadian misalignment and the risk of COVID-19 infection

Algal metabolites as novel drugs against viruses

Is SARS-CoV-2 a Superantigen?

One year after severe COVID-19, T cells persist against SARS-CoV-2

Northwestern scientists continue to advance the understanding of COVID-19

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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